Panama Canal, Central America Cruises : Best Cruise Prices

Ports

Seattle, Washington
Vancouver (Canada Place), British Columbia
Santa Barbara, California
San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida

Ports

Seattle, Washington - Vancouver (Canada Place), British Columbia - Santa Barbara, California - San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports

21 Night Panama Canal - Eastbound (Seattle To Ft. Lauderdale)

Eurodam L

4.1

(1074 Reviews)

2024 sail dates: Oct 05

$1449*

$69/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1074 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
	N/A	N/A	N/A	$5851*
See Offers	$1449*	$1689*	$2789*	$5839*
	$1449*	$1689*	$2789*	$5839*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Panama Canal Transit
PANAMA CITY (FUERTE AMADOR), PANAMA
Puntarenas, Costa Rica
Puerto Chiapas (Tapachula), Mexico
Huatulco, Mexico
Puerto Vallarta, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Panama Canal Transit - PANAMA CITY (FUERTE AMADOR), PANAMA - Puntarenas, Costa Rica - Puerto Chiapas (Tapachula), Mexico - Huatulco, Mexico - Puerto Vallarta, Mexico - San Pedro (Los Angeles), California - View more ports

16 Night Panama Canal - Ocean To Ocean (Ft. Lauderdale To Los Angeles)

Coral Princess M

4.1

(825 Reviews)

2025 sail dates: Mar 09, Apr 10

$1057*

$66/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 825 Coral Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1057*	$1247*	$1747*	N/A
See Offers	$1058*	$1209*	$1748*	$2513*
See Offers	$1058*	$1209*	$1748*	$2513*
See Offers	$1058*	$1209*	$1748*	$2513*
See Offers	$1058*	$1209*	$1748*	$2513*
See Offers	$1058*	$1209*	$1748*	$2513*
	$1070*	$1221*	$1760*	$2525*
See Offers	$1058*	$1209*	$1748*	$2513*
See Offers	$1058*	$1209*	$1748*	$2513*
	$1058*	$1209*	$1748*	$2513*
	$1247*	$1597*	$2547*	N/A
See Offers	$1248*	$1426*	$2548*	$2597*
See Offers	$1248*	$1426*	$2548*	$2597*
See Offers	$1248*	$1426*	$2548*	$2597*
See Offers	$1248*	$1426*	$2548*	$2597*
See Offers	$1248*	$1426*	$2548*	$2597*
See Offers	$1248*	$1426*	$2548*	$2597*
	$1248*	$1426*	$2548*	$2597*

Ports

Ft. Lauderdale (Port Everglades), Florida
Grand Turk Island
Oranjestad, Aruba
Cartagena, Colombia
Panama Canal Transit
Puerto Caldera, Costa Rica
Acajutla
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal Transit - Puerto Caldera, Costa Rica - Acajutla - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

17 Night Panama Canal (Ft. Lauderdale To San Diego)

Nieuw Amsterdam L

4.1

(775 Reviews)

2025 sail dates: Apr 13

$1529*

$90/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 775 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1529*	$1779*	$3059*	$6059*
See Offers	$1529*	$1779*	$3059*	$6059*
See Offers	$1529*	$1779*	$3059*	$6059*
See Offers	$1529*	$1779*	$3059*	$6059*
See Offers	$1529*	$1779*	$3059*	$6059*
See Offers	$1529*	$1779*	$3059*	$6059*
	N/A	N/A	N/A	$6071*
See Offers	$1529*	$1779*	$3059*	$6059*
	$1529*	$1779*	$3059*	$6059*

Ports

San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Fuerte Amador, Panama
Panama Canal Transit
Cartagena, Colombia
Half Moon Cay, Bahamas (Private Island)
Miami, Florida

View more ports

Ports

San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Fuerte Amador, Panama - Panama Canal Transit - Cartagena, Colombia - Half Moon Cay, Bahamas (Private Island) - Miami, Florida - View more ports

15 Night Panama Canal (San Diego To Miami)

Zuiderdam M

4.0

(740 Reviews)

2026 sail dates: Feb 27

$1999*

$133/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 740 Zuiderdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
	N/A	N/A	N/A	$4311*
See Offers	$1999*	$2299*	$3099*	$4299*
	$1999*	$2284*	$3072*	$4299*

Ports

Vancouver (Canada Place), British Columbia
San Francisco, California
San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puerto Corinto, Nicaragua
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida
Grand Turk Island
Charlotte Amalie, St. Thomas
San Juan, Puerto Rico
Half Moon Cay, Bahamas (Private Island)

View more ports

Ports

Vancouver (Canada Place), British Columbia - San Francisco, California - San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puerto Corinto, Nicaragua - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - Charlotte Amalie, St. Thomas - San Juan, Puerto Rico - Half Moon Cay, Bahamas (Private Island) - View more ports

28 Night Panama Canal & Eastern Caribbean (Ft. Lauderdale Roundtrip)

Nieuw Amsterdam L

4.1

(775 Reviews)

2024 sail dates: Sep 29

$2109*

$75/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 775 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
	N/A	N/A	N/A	$8031*
See Offers	$2109*	$2419*	$4269*	$8019*
	$2109*	$2419*	$4269*	$8019*

Ports

San Diego, California
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida

View more ports

Ports

San Diego, California - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports

16 Night Panama Canal (San Diego To Ft. Lauderdale)

Nieuw Amsterdam L

4.1

(775 Reviews)

2024 sail dates: Oct 04

$1349*

$84/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 775 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$5849*
See Offers	$1349*	$1499*	$2764*	$6464*
	N/A	N/A	N/A	$6476*
See Offers	$1349*	$1499*	$2764*	$5849*
	$1349*	$1499*	$2764*	$6464*

Ports

San Diego, California
Cabo San Lucas, Mexico
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida
Grand Turk Island
Charlotte Amalie, St. Thomas
San Juan, Puerto Rico
Half Moon Cay, Bahamas (Private Island)

View more ports

Ports

San Diego, California - Cabo San Lucas, Mexico - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - Charlotte Amalie, St. Thomas - San Juan, Puerto Rico - Half Moon Cay, Bahamas (Private Island) - View more ports

23 Night Panama Canal & Eastern Caribbean (San Diego To Ft. Lauderdale)

Nieuw Amsterdam L

4.1

(775 Reviews)

2024 sail dates: Oct 04

$1974*

$86/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 775 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1974*	$2344*	$3754*	$7764*
See Offers	$1974*	$2344*	$3754*	$7399*
See Offers	$1974*	$2344*	$3754*	$7399*
See Offers	$1974*	$2344*	$3754*	$7399*
See Offers	$1974*	$2344*	$3754*	$7764*
See Offers	$1974*	$2344*	$3754*	$7764*
	N/A	N/A	N/A	$7776*
See Offers	$1974*	$2344*	$3754*	$7764*
	$1974*	$2344*	$3754*	$7399*

Ports

Ft. Lauderdale (Port Everglades), Florida
Ocho Rios, Jamaica
Oranjestad, Aruba
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Ocho Rios, Jamaica - Oranjestad, Aruba - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1179 Reviews)

2024 sail dates: Dec 06

$717*

$60/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1179 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$717*	$947*	$1347*	$3698*
See Offers	$718*	$838*	$1348*	$1948*
See Offers	$718*	$838*	$1348*	$1948*
See Offers	$718*	$838*	$1348*	$1948*
See Offers	$718*	$838*	$1348*	$1948*
See Offers	$718*	$838*	$1348*	$1948*
	$730*	$850*	$1360*	$1960*
See Offers	$718*	$838*	$1348*	$1948*
See Offers	$718*	$838*	$1348*	$1948*
	$718*	$838*	$1348*	$1948*

Ports

Ft. Lauderdale (Port Everglades), Florida
Amber Cove (Puerto Plata), Dominican Republic
San Juan, Puerto Rico
Charlotte Amalie, St. Thomas
Half Moon Cay, Bahamas (Private Island)
Grand Turk Island
Oranjestad, Aruba
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Amber Cove (Puerto Plata), Dominican Republic - San Juan, Puerto Rico - Charlotte Amalie, St. Thomas - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

24 Night Eastern Caribbean & Panama Canal (Ft. Lauderdale To San Diego)

Nieuw Amsterdam L

4.1

(775 Reviews)

2025 sail dates: Apr 06

$2129*

$89/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 775 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2129*	$2549*	$4039*	$7749*
See Offers	$2129*	$2549*	$4039*	$7749*
See Offers	$2129*	$2549*	$4039*	$7749*
See Offers	$2129*	$2549*	$4039*	$7749*
See Offers	$2129*	$2549*	$4039*	$7749*
See Offers	$2129*	$2549*	$4039*	$7749*
	N/A	N/A	N/A	$7761*
See Offers	$2129*	$2549*	$4039*	$7749*
	$2129*	$2549*	$4039*	$7749*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Panama Canal Transit
PANAMA CITY (FUERTE AMADOR), PANAMA
Puntarenas, Costa Rica
San Juan Del Sur, Nicaragua
Huatulco, Mexico
Puerto Vallarta, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Panama Canal Transit - PANAMA CITY (FUERTE AMADOR), PANAMA - Puntarenas, Costa Rica - San Juan Del Sur, Nicaragua - Huatulco, Mexico - Puerto Vallarta, Mexico - San Pedro (Los Angeles), California - View more ports

16 Night Panama Canal - Ocean To Ocean (Ft. Lauderdale To Los Angeles)

Emerald Princess L

4.0

(1179 Reviews)

2025 sail dates: Nov 02

$1197*

$75/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1179 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1197*	$1497*	$2197*	$5498*
See Offers	$1198*	$1369*	$2198*	$3398*
See Offers	$1198*	$1369*	$2198*	$3398*
See Offers	$1198*	$1369*	$2198*	$3398*
See Offers	$1198*	$1369*	$2198*	$2711*
See Offers	$1198*	$1369*	$2198*	$2711*
	$1210*	$1381*	$2210*	$2723*
See Offers	$1198*	$1369*	$2198*	$2711*
See Offers	$1198*	$1369*	$2198*	$2711*
	$1198*	$1369*	$2198*	$3398*

Panama Canal, Central America cruises 325 Panama Canal, Central America Cruises Found

Your search Clear selections

325 cruises found

Sort by

Filter by

More popular cruise lines sailing to Panama Canal, Central America

More popular departure ports with sailings to Panama Canal, Central America