Panama Canal, Central America Cruises : Best Cruise Prices

Sponsored cruise

Ports

Miami, Florida
George Town, Grand Cayman
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
Harvest Caye, Belize
Cozumel, Mexico

Ports

Miami, Florida - George Town, Grand Cayman - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Harvest Caye, Belize - Cozumel, Mexico - View more ports

11 Night Panama Canal: Mexico Costa Rica & Belize (Miami Roundtrip)

Norwegian Gem L

3.8

(2493 Reviews)

2025 sail dates: Jan 03

$1091*

$99/night*

Inside

View Deal

Loading itinerary...

Loading reviews...

Read all 2493 Norwegian Gem reviews

Sponsored cruise

Ports

New York, New York
Ft. Lauderdale (Port Everglades), Florida
Philipsburg, St. Maarten
Castries, St. Lucia
Bridgetown, Barbados
Devils Island, French Guiana
Cruise Amazon River
CRUISE BARRA NORTE RIVER
Macapa, Brazil
Cross The Equator
Santarem, Brazil
Boca Da Valeria, Brazil
Manaus, Brazil
Parintins, Brazil
Alter Do Chao, Brazil
Port of Spain
Willemstad, Curacao
Oranjestad, Aruba

View more ports

Ports

New York, New York - Ft. Lauderdale (Port Everglades), Florida - Philipsburg, St. Maarten - Castries, St. Lucia - Bridgetown, Barbados - Devils Island, French Guiana - Cruise Amazon River - CRUISE BARRA NORTE RIVER - Macapa, Brazil - Cross The Equator - Santarem, Brazil - Boca Da Valeria, Brazil - Manaus, Brazil - Parintins, Brazil - Alter Do Chao, Brazil - Port of Spain - Willemstad, Curacao - Oranjestad, Aruba - View more ports

30 Night Amazon Explorer (New York To Ft. Lauderdale)

Volendam M

4.0

(296 Reviews)

2025 sail dates: Nov 21

$5284*

$176/night*

Inside

View Deal

Loading itinerary...

Loading reviews...

Read all 296 Volendam reviews

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Falmouth, Jamaica
Mahogany Bay, Roatan, Bay Islands, Honduras
Belize City, Belize
Cozumel, Mexico
Key West, Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Huatulco, Mexico
Puerto Vallarta, Mexico
San Diego, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Falmouth, Jamaica - Mahogany Bay, Roatan, Bay Islands, Honduras - Belize City, Belize - Cozumel, Mexico - Key West, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - San Diego, California - View more ports

24 Night Western Caribbean Explorer & Panama Canal (Ft. Lauderdale To San Diego)

Eurodam L

4.1

(1100 Reviews)

2025 sail dates: Apr 02

$2604*

$109/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1100 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2604*	$3024*	$5094*	N/A
	$2779*	$3199*	$5269*	N/A
	N/A	N/A	$5269*	N/A
See Offers	$2779*	$3199*	$5269*	N/A
See Offers	$2779*	$3199*	$5269*	N/A
See Offers	$2779*	$3199*	$5269*	N/A
	$2779*	$3199*	$5269*	N/A
See Offers	$2779*	$3199*	$5269*	N/A

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Huatulco, Mexico
Puerto Vallarta, Mexico
San Diego, California
Catalina Island, California
San Francisco, California
Vancouver (Canada Place), British Columbia
Seattle, Washington

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - San Diego, California - Catalina Island, California - San Francisco, California - Vancouver (Canada Place), British Columbia - Seattle, Washington - View more ports

21 Night Panama Canal (Ft. Lauderdale To Seattle)

Eurodam L

4.1

(1100 Reviews)

2025 sail dates: Apr 12

$1884*

$90/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1100 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1884*	$2084*	$3689*	$7239*
	$2689*	$2889*	$4494*	$8044*
	N/A	N/A	N/A	$7369*
	$2689*	$2889*	$4494*	$8044*
See Offers	$2039*	$2239*	$3844*	$7394*
See Offers	$2039*	$2239*	$3844*	$7394*
	$2689*	$2889*	$4494*	$8044*
See Offers	$2039*	$2239*	$3844*	$7394*

Ports

Ft. Lauderdale (Port Everglades), Florida
George Town, Grand Cayman
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Pedro (Los Angeles), California - View more ports

16 Night Panama Canal Westward (Ft. Lauderdale To Los Angeles)

Serenade of the Seas L

4.1

(1797 Reviews)

2025 sail dates: Apr 13

$1655*

$103/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1797 Serenade of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1655*	$1881*	$3329*	$8848*
	$1651*	$1877*	$3325*	$8844*
See Offers	$1655*	$1882*	$3329*	$8848*
See Offers	$1635*	$1861*	$3309*	$8828*
	$1655*	$1881*	$3329*	$8848*
See Offers	$1635*	$1861*	$3309*	$8828*
	$1655*	$1881*	$3329*	$8848*
	$1655*	$1881*	$3329*	$8848*
See Offers	$1655*	$1882*	$3329*	$8848*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Grand Turk Island
Amber Cove (Puerto Plata), Dominican Republic
Nassau, Bahamas
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California
Catalina Island, California
Vancouver (Canada Place), British Columbia

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Amber Cove (Puerto Plata), Dominican Republic - Nassau, Bahamas - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Catalina Island, California - Vancouver (Canada Place), British Columbia - View more ports

26 Night Eastern Caribbean Explorer & Panama Canal (Ft. Lauderdale To Vancouver)

Eurodam L

4.1

(1100 Reviews)

2026 sail dates: Mar 29

$3644*

$140/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1100 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3644*	$4254*	$5374*	$8694*
	$3849*	$4459*	$5579*	$8899*
	N/A	N/A	N/A	$8874*
See Offers	$3849*	$4459*	$5579*	$8899*
See Offers	$3849*	$4459*	$5579*	$8899*
See Offers	$3849*	$4459*	$5579*	$8899*
	$3849*	$4459*	$5579*	$8899*
See Offers	$3849*	$4459*	$5579*	$8899*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

15 Night Panama Canal (Ft. Lauderdale To San Diego)

Eurodam L

4.1

(1100 Reviews)

2026 sail dates: Apr 05

$2609*

$174/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1100 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2609*	$3049*	$3839*	$6139*
	$3224*	$3664*	$4454*	$6754*
	N/A	N/A	N/A	$6204*
See Offers	$3224*	$3664*	$4454*	$6754*
See Offers	$2699*	$3139*	$3929*	$6229*
See Offers	$2699*	$3139*	$3929*	$6229*
	$3224*	$3664*	$4454*	$6754*
See Offers	$2699*	$3139*	$3929*	$6229*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California
Catalina Island, California
Vancouver (Canada Place), British Columbia

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Catalina Island, California - Vancouver (Canada Place), British Columbia - View more ports

19 Night Panama Canal (Ft. Lauderdale To Vancouver)

Eurodam L

4.1

(1100 Reviews)

2026 sail dates: Apr 05

$2829*

$149/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1100 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2829*	$3319*	$4209*	$6659*
	$2944*	$3434*	$4324*	$6774*
	N/A	N/A	N/A	$6749*
See Offers	$2944*	$3434*	$4324*	$6774*
See Offers	$2944*	$3434*	$4324*	$6774*
See Offers	$2944*	$3434*	$4324*	$6774*
	$2944*	$3434*	$4324*	$6774*
See Offers	$2944*	$3434*	$4324*	$6774*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
Princess Cays (Cruise Line Private Island)

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Princess Cays (Cruise Line Private Island) - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1889 Reviews)

2026 sail dates: Oct 30, Nov 23, Dec 05

2027 sail dates: Jan 10, Jan 22

$1099*

$92/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1889 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1149*	$1399*	$2099*	$4399*
	$1149*	$1259*	$2099*	$2949*
See Offers	$1149*	$1259*	$2099*	$2949*
See Offers	$1149*	$1259*	$2099*	$2949*
	$1149*	$1259*	$2099*	$2949*
See Offers	$1149*	$1259*	$2099*	$2949*
	$1149*	$1259*	$2099*	$2949*
	$1199*	$1449*	$2149*	$4499*
	$1199*	$1319*	$2149*	$2999*
See Offers	$1199*	$1319*	$2149*	$2999*
See Offers	$1199*	$1319*	$2149*	$2999*
	$1199*	$1319*	$2149*	$2999*
See Offers	$1199*	$1319*	$2149*	$2999*
	$1199*	$1319*	$2149*	$2999*
	$1099*	$1299*	$1949*	$4099*
	$1099*	$1199*	$1949*	$2749*
See Offers	$1099*	$1199*	$1949*	$2749*
See Offers	$1099*	$1199*	$1949*	$2749*
	$1099*	$1199*	$1949*	$2749*
See Offers	$1099*	$1199*	$1949*	$2749*
	$1099*	$1199*	$1949*	$2749*
	$1149*	$1399*	$2099*	$4399*
	$1149*	$1269*	$2099*	$2949*
See Offers	$1149*	$1269*	$2099*	$2949*
See Offers	$1149*	$1269*	$2099*	$2949*
	$1149*	$1269*	$2099*	$2949*
See Offers	$1149*	$1269*	$2099*	$2949*
	$1149*	$1269*	$2099*	$2949*
	$1149*	$1399*	$2099*	$4399*
	$2709*	$2919*	$4419*	$5949*
See Offers	$1149*	$1259*	$2099*	$2949*
See Offers	$1149*	$1259*	$2099*	$2949*
	$2709*	$2919*	$4419*	$5949*
See Offers	$1149*	$1259*	$2099*	$2949*
	$2709*	$2919*	$4419*	$5949*

Ports

Miami, Florida
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Acapulco, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Miami, Florida - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

15 Night Panama Canal: Mexico & Costa Rica (Miami To San Diego)

Norwegian Star L

3.6

(2053 Reviews)

2026 sail dates: Dec 04

$1868*

$125/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2053 Norwegian Star reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$1868*	$2318*	$3168*	$4418*
See Offers	$1868*	$2318*	$3168*	$3818*
	$1868*	$2318*	$3168*	$3818*
	$1868*	$2318*	$3168*	$3818*
See Offers	$1868*	$2318*	$3168*	$3818*
See Offers	$1868*	$2318*	$3168*	$3818*
	$1868*	$2318*	$3168*	$3818*
See Offers	$1868*	$2318*	$3168*	$3818*
See Offers	$1868*	$2318*	$3168*	$3818*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Willemstad, Curacao
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
Ocho Rios, Jamaica

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Willemstad, Curacao - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Ocho Rios, Jamaica - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1206 Reviews)

2024 sail dates: Dec 30

$1239*

$103/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1206 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1239*	$1701*	N/A	N/A
See Offers	N/A	N/A	N/A	$3568*
See Offers	N/A	N/A	N/A	$3568*
See Offers	N/A	N/A	N/A	$3568*

Ports

Seattle, Washington
San Francisco, California
San Pedro (Los Angeles), California
Cabo San Lucas, Mexico
Puerto Vallarta, Mexico
Manzanillo, Mexico
Acapulco, Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
Panama City, Panama
Panama Canal Transit
Cartagena, Colombia
Miami, Florida

View more ports

Ports

Seattle, Washington - San Francisco, California - San Pedro (Los Angeles), California - Cabo San Lucas, Mexico - Puerto Vallarta, Mexico - Manzanillo, Mexico - Acapulco, Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama City, Panama - Panama Canal Transit - Cartagena, Colombia - Miami, Florida - View more ports

20 Night Panama Canal: Mexico & Costa Rica (Seattle To Miami)

Norwegian Encore XL

4.3

(693 Reviews)

2025 sail dates: Oct 19

$2258*

$113/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 693 Norwegian Encore reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$2258*	$2928*	$3568*	$11298*
See Offers	$2258*	$2928*	$3568*	$4118*
	$2258*	$2928*	$3568*	$4118*
	$2258*	$2928*	$3568*	$4118*
See Offers	$2258*	$2928*	$3568*	$4118*
See Offers	$2258*	$2928*	$3568*	$4118*
	$2258*	$2928*	$3568*	$4118*
See Offers	$2258*	$2928*	$3568*	$4118*
See Offers	$2258*	$2928*	$3568*	$4118*

Panama Canal, Central America cruises 386 Panama Canal, Central America Cruises Found

Your search Clear selections

386 cruises found

Sort by

Filter by

More popular cruise lines sailing to Panama Canal, Central America

More popular departure ports with sailings to Panama Canal, Central America