Panama Canal, Central America Cruises from Ft. Lauderdale (Port Everglades), Florida: Best Cruise Prices

Ports

Ft. Lauderdale (Port Everglades), Florida
George Town, Grand Cayman
Fuerte Amador, Panama
Panama Canal Transit
Cross The Equator
Manta, Ecuador
Salaverry (Trujillo), Peru
Callao (Lima), Peru
General San Martin (Pisco), Peru
Coquimbo (La Serena), Chile
San Antonio, Chile

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Fuerte Amador, Panama - Panama Canal Transit - Cross The Equator - Manta, Ecuador - Salaverry (Trujillo), Peru - Callao (Lima), Peru - General San Martin (Pisco), Peru - Coquimbo (La Serena), Chile - San Antonio, Chile - View more ports

17 Night Panama Canal & Inca Discovery (Ft. Lauderdale To San Antonio)

Oosterdam M

4.1

(889 Reviews)

2025 sail dates: Nov 17

$3249*

$191/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 889 Oosterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3249*	$3079*	$4349*	$5949*
	$2279*	$2529*	$3379*	$4979*
See Offers	$3299*	$3129*	$4399*	$5999*
See Offers	$2279*	$2529*	$3379*	$4979*
	$2279*	$2529*	$3379*	$4979*
See Offers	$3299*	$3129*	$4399*	$5999*
	N/A	N/A	N/A	$5974*
	$2279*	$2529*	$3379*	$4979*

Ports

Ft. Lauderdale (Port Everglades), Florida
George Town, Grand Cayman
Falmouth, Jamaica
Puerto Limon, Costa Rica
Colon, Panama
Panama Canal (Cruise Into Canal)
Oranjestad, Aruba
Willemstad, Curacao

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Falmouth, Jamaica - Puerto Limon, Costa Rica - Colon, Panama - Panama Canal (Cruise Into Canal) - Oranjestad, Aruba - Willemstad, Curacao - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1889 Reviews)

2025 sail dates: Nov 29

2026 sail dates: Feb 21

$999*

$83/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1889 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$999*	$1239*	$1689*	$4489*
	$999*	$1029*	$1689*	$2289*
See Offers	$999*	$1029*	$1689*	$2289*
	$999*	$1029*	$1689*	$2289*
See Offers	$999*	$1029*	$1689*	$2289*
See Offers	$999*	$1029*	$1689*	$2289*
	$999*	$1029*	$1689*	$2289*
	$1508*	$2058*	$2498*	$5069*
	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*
	$1508*	$1550*	$2498*	$3018*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Willemstad, Curacao
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Willemstad, Curacao - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1889 Reviews)

2026 sail dates: Jan 04, Jan 16, Mar 17

$1298*

$108/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1889 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1438*	$1788*	$2398*	$4659*
	$1438*	$1481*	$2398*	$2658*
See Offers	$1438*	$1481*	$2398*	$2658*
See Offers	$1438*	$1481*	$2398*	$2658*
See Offers	$1438*	$1481*	$2398*	$2658*
	$1438*	$1481*	$2398*	$2658*
	$1298*	$1948*	$2338*	$4919*
	$1299*	$1336*	$2339*	$2859*
See Offers	$1298*	$1335*	$2338*	$2858*
See Offers	$1299*	$1336*	$2339*	$2859*
See Offers	$1298*	$1335*	$2338*	$2858*
See Offers	$1298*	$1335*	$2338*	$2858*
	$1299*	$1336*	$2339*	$2859*
	$1628*	$2058*	$2488*	$5059*
	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
	$1628*	$1677*	$2488*	$3008*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Grand Turk Island
Amber Cove (Puerto Plata), Dominican Republic
Nassau, Bahamas
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Amber Cove (Puerto Plata), Dominican Republic - Nassau, Bahamas - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

22 Night Eastern Caribbean Explorer & Panama Canal (Ft. Lauderdale To San Diego)

Eurodam L

4.1

(1100 Reviews)

2026 sail dates: Mar 29

$3454*

$157/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1100 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3454*	$4014*	$5034*	$8204*
	$3634*	$4194*	$5214*	$8384*
See Offers	$3634*	$4194*	$5214*	$8384*
See Offers	$3634*	$4194*	$5214*	$8384*
	$3634*	$4194*	$5214*	$8384*
See Offers	$3634*	$4194*	$5214*	$8384*
	N/A	N/A	N/A	$8359*
	$3634*	$4194*	$5214*	$8384*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Willemstad, Curacao
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
Ocho Rios, Jamaica

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Willemstad, Curacao - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - Ocho Rios, Jamaica - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1206 Reviews)

2024 sail dates: Nov 24

$939*

$78/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1206 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$939*	N/A	$1987*	N/A
	$939*	$1592*	N/A	N/A
See Offers	$953*	$1592*	N/A	$2578*
See Offers	$939*	$1592*	N/A	N/A
See Offers	$953*	$1592*	N/A	$2578*
	$939*	$1592*	N/A	N/A

Ports

Ft. Lauderdale (Port Everglades), Florida
Grand Turk Island
Oranjestad, Aruba
Cartagena, Colombia
Panama Canal Transit
Puerto Caldera, Costa Rica
Acajutla
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California
Victoria, British Columbia
Vancouver (Canada Place), British Columbia

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal Transit - Puerto Caldera, Costa Rica - Acajutla - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Victoria, British Columbia - Vancouver (Canada Place), British Columbia - View more ports

21 Night Panama Canal (Ft. Lauderdale To Vancouver)

Nieuw Amsterdam L

4.1

(788 Reviews)

2025 sail dates: Apr 13

$1894*

$90/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 788 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1894*	$2094*	$3594*	$6394*
	$2594*	$2794*	$4294*	$7094*
See Offers	$2039*	$2239*	$3739*	$6539*
See Offers	$2039*	$2239*	$3739*	$6539*
	$2594*	$2794*	$4294*	$7094*
See Offers	$2039*	$2239*	$3739*	$6539*
	N/A	N/A	N/A	$6514*
	$2594*	$2794*	$4294*	$7094*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Oranjestad, Aruba
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
Falmouth, Jamaica

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Oranjestad, Aruba - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - Falmouth, Jamaica - View more ports

12 Night Panama Canal Discovery: Costa Rica & Greater Antilles (Ft. Lauderdale Roundtrip)

Rotterdam L

4.4

(256 Reviews)

2025 sail dates: Nov 16

$1464*

$122/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 256 Rotterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1464*	$2014*	$2164*	$3514*
	$1604*	$2154*	$2304*	$3654*
See Offers	$1604*	$2154*	$2304*	$3654*
See Offers	$1604*	$2154*	$2304*	$3654*
	$1604*	$2154*	$2304*	$3654*
See Offers	$1604*	$2154*	$2304*	$3654*
	N/A	N/A	N/A	$3629*
	$1604*	$2154*	$2304*	$3654*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Panama Canal Transit
PANAMA CITY (FUERTE AMADOR), PANAMA
Puntarenas, Costa Rica
Puerto Chiapas (Tapachula), Mexico
Huatulco, Mexico
Puerto Vallarta, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Panama Canal Transit - PANAMA CITY (FUERTE AMADOR), PANAMA - Puntarenas, Costa Rica - Puerto Chiapas (Tapachula), Mexico - Huatulco, Mexico - Puerto Vallarta, Mexico - San Pedro (Los Angeles), California - View more ports

16 Night Panama Canal - Ocean To Ocean Holiday (Ft. Lauderdale To Los Angeles)

Island Princess M

4.0

(908 Reviews)

2026 sail dates: Dec 12

$1499*

$94/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 908 Island Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1499*	$1699*	$2799*	$6099*
	$1499*	$1669*	$2669*	$3219*
See Offers	$1499*	$1669*	$2669*	$3219*
See Offers	$1499*	$1669*	$2669*	$3219*
See Offers	$1499*	$1669*	$2669*	$3219*
See Offers	$1499*	$1669*	$2669*	$3219*
	$1499*	$1669*	$2669*	$3219*

Ports

Ft. Lauderdale (Port Everglades), Florida
George Town, Grand Cayman
Puerto Limon, Costa Rica
Colon, Panama
Panama Canal (Cruise Into Canal)
Oranjestad, Aruba
Willemstad, Curacao

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Puerto Limon, Costa Rica - Colon, Panama - Panama Canal (Cruise Into Canal) - Oranjestad, Aruba - Willemstad, Curacao - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1206 Reviews)

2024 sail dates: Dec 18

$1239*

$103/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1206 Emerald Princess reviews

Compare Prices

Partners	Bonus Offers	Inside	Oceanview	Balcony	Suite
	See Offers	$1239*	$1486*	N/A	$2850*
	See Offers	$1239*	$1486*	N/A	$2850*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Falmouth, Jamaica
Mahogany Bay, Roatan, Bay Islands, Honduras
Belize City, Belize
Cozumel, Mexico
Key West, Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Huatulco, Mexico
Puerto Vallarta, Mexico
San Diego, California
San Francisco, California
Victoria, British Columbia
Vancouver (Canada Place), British Columbia
Seattle, Washington

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Falmouth, Jamaica - Mahogany Bay, Roatan, Bay Islands, Honduras - Belize City, Belize - Cozumel, Mexico - Key West, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - San Diego, California - San Francisco, California - Victoria, British Columbia - Vancouver (Canada Place), British Columbia - Seattle, Washington - View more ports

31 Night Western Caribbean Explorer & Panama Canal (Ft. Lauderdale To Seattle)

Eurodam L

4.1

(1100 Reviews)

2025 sail dates: Apr 02

$3039*

$98/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1100 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3039*	$3419*	$5559*	$9979*
	$3294*	$3674*	$5814*	$10234*
See Offers	$3294*	$3674*	$5814*	$10234*
See Offers	$3294*	$3674*	$5814*	$10234*
	$3294*	$3674*	$5814*	$10234*
See Offers	$3294*	$3674*	$5814*	$10234*
	N/A	N/A	N/A	$10209*
	$3294*	$3674*	$5814*	$10234*

Cruises to Panama Canal, Central America leaving Ft. Lauderdale (Port Everglades), Florida cruise port 118 Panama Canal, Central America Cruises Found

Your search Clear selections

118 cruises found

Sort by

Filter by

More popular departure ports with sailing to Panama Canal, Central America

More popular cruise destinations from Ft. Lauderdale (Port Everglades), Florida

More popular cruise lines that sail to Panama Canal, Central America