Puerto Quetzal, Guatemala Cruises: Top Itineraries and Pricing

Ports

San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Fuerte Amador, Panama
Panama Canal Transit
Cartagena, Colombia
Half Moon Cay, Bahamas (Private Island)
Miami, Florida

Ports

San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Fuerte Amador, Panama - Panama Canal Transit - Cartagena, Colombia - Half Moon Cay, Bahamas (Private Island) - Miami, Florida - View more ports

15 Night Panama Canal (San Diego To Miami)

Zuiderdam M

4.0

(740 Reviews)

2026 sail dates: Feb 27

$1999*

$133/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 740 Zuiderdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
	$1999*	$2284*	$3072*	$4299*
	$2011*	$2311*	$3111*	$4311*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
PANAMA CITY (FUERTE AMADOR), PANAMA
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Manzanillo, Mexico
San Francisco, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - PANAMA CITY (FUERTE AMADOR), PANAMA - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Manzanillo, Mexico - San Francisco, California - View more ports

16 Night Panama Canal - Ocean To Ocean Holiday (Ft. Lauderdale To San Francisco)

Island Princess M

4.0

(896 Reviews)

2025 sail dates: Nov 21

$1397*

$87/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 896 Island Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1397*	$2047*	$2397*	$5898*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
	$1390*	$1590*	$2340*	$2765*
See Offers	$1398*	$1598*	$2348*	$2773*
	$1398*	$1598*	$2348*	$2773*

Ports

San Francisco, California
Puerto Vallarta, Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
PANAMA CITY (FUERTE AMADOR), PANAMA
Panama Canal Transit
Cartagena, Colombia
Ft. Lauderdale (Port Everglades), Florida

View more ports

Ports

San Francisco, California - Puerto Vallarta, Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Cartagena, Colombia - Ft. Lauderdale (Port Everglades), Florida - View more ports

16 Night Panama Canal - Ocean To Ocean (San Francisco To Ft. Lauderdale)

Island Princess M

4.0

(896 Reviews)

2025 sail dates: Dec 07

$1397*

$87/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 896 Island Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1397*	$2047*	$2397*	$5898*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
See Offers	$1398*	$1598*	$2348*	$2773*
	$1390*	$1590*	$2340*	$2765*
See Offers	$1398*	$1598*	$2348*	$2773*
	$1398*	$1598*	$2348*	$2773*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Huatulco, Mexico
Puerto Vallarta, Mexico
San Diego, California
Catalina Island, California
San Francisco, California
Vancouver (Canada Place), British Columbia
Seattle, Washington

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - San Diego, California - Catalina Island, California - San Francisco, California - Vancouver (Canada Place), British Columbia - Seattle, Washington - View more ports

21 Night Panama Canal (Ft. Lauderdale To Seattle)

Eurodam L

4.1

(1074 Reviews)

2025 sail dates: Apr 12

$1739*

$83/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1074 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1739*	$1939*	$3239*	$6589*
See Offers	$1739*	$1939*	$3239*	$6589*
See Offers	$1739*	$1939*	$3239*	$6589*
See Offers	$1739*	$1939*	$3239*	$6589*
See Offers	$1739*	$1939*	$3239*	$6589*
See Offers	$1739*	$1939*	$3239*	$6589*
See Offers	$1739*	$1939*	$3239*	$6589*
See Offers	$1739*	$1939*	$3239*	$6589*
	$1739*	$1939*	$3239*	$6589*
	$1751*	$1951*	$3251*	$6601*

Ports

Miami, Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Huatulco, Mexico
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Miami, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

15 Night Panama Canal (Miami To San Diego)

Zuiderdam M

4.0

(740 Reviews)

2026 sail dates: Jan 31

$1999*

$133/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 740 Zuiderdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2284*	$3072*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
See Offers	$1999*	$2299*	$3099*	$4299*
	$1999*	$2284*	$3072*	$4299*
	$2011*	$2311*	$3111*	$4311*

Ports

Vancouver (Canada Place), British Columbia
San Francisco, California
San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puerto Corinto, Nicaragua
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida
Grand Turk Island
Charlotte Amalie, St. Thomas
San Juan, Puerto Rico
Half Moon Cay, Bahamas (Private Island)

View more ports

Ports

Vancouver (Canada Place), British Columbia - San Francisco, California - San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puerto Corinto, Nicaragua - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - Charlotte Amalie, St. Thomas - San Juan, Puerto Rico - Half Moon Cay, Bahamas (Private Island) - View more ports

28 Night Panama Canal & Eastern Caribbean (Ft. Lauderdale Roundtrip)

Nieuw Amsterdam L

4.1

(774 Reviews)

2024 sail dates: Sep 29

$2109*

$75/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 774 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
See Offers	$2109*	$2419*	$4269*	$8019*
	$2109*	$2419*	$4269*	$8019*
	$2121*	$2431*	$4281*	$8031*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - San Pedro (Los Angeles), California - View more ports

15 Night World Voyage Segment - Panama Canal Connoisseur (Ft. Lauderdale To Los Angeles)

Island Princess M

4.0

(896 Reviews)

2025 sail dates: Jan 05, May 02

$1217*

$81/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 896 Island Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1217*	$1697*	$2127*	N/A
See Offers	$1218*	$1312*	$2081*	$2805*
See Offers	$1218*	$1312*	$2081*	$2805*
See Offers	$1218*	$1312*	$2081*	$2805*
See Offers	$1218*	$1312*	$2081*	$2805*
See Offers	$1218*	$1312*	$2081*	$2805*
See Offers	$1218*	$1312*	$2081*	$2805*
See Offers	$1218*	$1312*	$2081*	$2805*
	$1210*	$1304*	$2073*	$2797*
See Offers	$1218*	$1312*	$2081*	$2805*
	$1218*	$1312*	$2081*	$2805*
	$1443*	$1797*	$2297*	$5198*
See Offers	$1443*	$1491*	$2251*	$3139*
See Offers	$1443*	$1491*	$2251*	$3139*
See Offers	$1443*	$1491*	$2251*	$3139*
See Offers	$1443*	$1491*	$2251*	$3139*
See Offers	$1443*	$1491*	$2251*	$3139*
See Offers	$1443*	$1491*	$2251*	$3139*
	$1435*	$1483*	$2243*	$3131*
See Offers	$1443*	$1491*	$2251*	$3139*
	$1443*	$1491*	$2251*	$3139*

Ports

Vancouver (Canada Place), British Columbia
San Francisco, California
San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puerto Corinto, Nicaragua
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida

View more ports

Ports

Vancouver (Canada Place), British Columbia - San Francisco, California - San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puerto Corinto, Nicaragua - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports

21 Night Panama Canal (Vancouver To Ft. Lauderdale)

Nieuw Amsterdam L

4.1

(774 Reviews)

2024 sail dates: Sep 29

$1489*

$71/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 774 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1489*	$1689*	$3089*	$6739*
See Offers	$1489*	$1689*	$3089*	$6399*
See Offers	$1489*	$1689*	$3089*	$6399*
See Offers	$1489*	$1689*	$3089*	$6399*
See Offers	$1489*	$1689*	$3089*	$6739*
See Offers	$1489*	$1689*	$3089*	$6739*
See Offers	$1489*	$1689*	$3089*	$6739*
	$1489*	$1689*	$3089*	$6399*
	$1501*	$1701*	$3101*	$6751*

Ports

San Diego, California
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida

View more ports

Ports

San Diego, California - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports

16 Night Panama Canal (San Diego To Ft. Lauderdale)

Nieuw Amsterdam L

4.1

(774 Reviews)

2024 sail dates: Oct 04

$1349*

$84/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 774 Nieuw Amsterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$5849*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
See Offers	$1349*	$1499*	$2764*	$6464*
	$1349*	$1499*	$2764*	$6464*
	$1361*	$1511*	$2776*	$6476*

Ports

Seattle, Washington
Vancouver (Canada Place), British Columbia
Santa Barbara, California
San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida

View more ports

Ports

Seattle, Washington - Vancouver (Canada Place), British Columbia - Santa Barbara, California - San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports

21 Night Panama Canal - Eastbound (Seattle To Ft. Lauderdale)

Eurodam L

4.1

(1074 Reviews)

2024 sail dates: Oct 05

$1449*

$69/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1074 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
See Offers	$1449*	$1689*	$2789*	$5839*
	$1449*	$1689*	$2789*	$5839*
	$1449*	$1689*	$2789*	$5839*

Puerto Quetzal, Guatemala cruises 103 Puerto Quetzal, Guatemala cruises

Your search Clear selections

103 cruises found

Sort by

Filter by