Panama Canal, Central America cruises 385 Panama Canal, Central America Cruises Found
Your search Clear selections
385 cruises found
Sort by
Filter by
Ports
- Miami, Florida
- George Town, Grand Cayman
- Cartagena, Colombia
- Panama Canal (Cruise Into Canal)
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Ports
Miami, Florida - George Town, Grand Cayman - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Harvest Caye, Belize - Cozumel, Mexico - View more ports
11 Night Panama Canal: Mexico Costa Rica & Belize (Miami Roundtrip)
2025 sail dates:
Ports
- New York, New York
- Ft. Lauderdale (Port Everglades), Florida
- Philipsburg, St. Maarten
- Castries, St. Lucia
- Bridgetown, Barbados
- Devils Island, French Guiana
- Cruise Amazon River
- CRUISE BARRA NORTE RIVER
- Macapa, Brazil
- Cross The Equator
- Santarem, Brazil
- Boca Da Valeria, Brazil
- Manaus, Brazil
- Parintins, Brazil
- Alter Do Chao, Brazil
- Port of Spain
- Willemstad, Curacao
- Oranjestad, Aruba
Ports
New York, New York - Ft. Lauderdale (Port Everglades), Florida - Philipsburg, St. Maarten - Castries, St. Lucia - Bridgetown, Barbados - Devils Island, French Guiana - Cruise Amazon River - CRUISE BARRA NORTE RIVER - Macapa, Brazil - Cross The Equator - Santarem, Brazil - Boca Da Valeria, Brazil - Manaus, Brazil - Parintins, Brazil - Alter Do Chao, Brazil - Port of Spain - Willemstad, Curacao - Oranjestad, Aruba - View more ports
Ports
- New York, New York
- Puerto Plata, Dominican Republic
- Cartagena, Colombia
- Colon, Panama
- Panama Canal (Cruise Into Canal)
- Ocho Rios, Jamaica
- Cozumel, Mexico
- Tampa, Florida
Ports
New York, New York - Puerto Plata, Dominican Republic - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Ocho Rios, Jamaica - Cozumel, Mexico - Tampa, Florida - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
See Offers |
$1829* |
$2229* |
$3309* |
$3579* |
|
|
See Offers |
$1829* |
$2229* |
$3309* |
$3579* |
|
|
|
See Offers |
$1829* |
$2229* |
$3309* |
$3579* |
|
|
|
See Offers |
$1829* |
$2229* |
$3309* |
$3579* |
Ports
- Miami, Florida
- Cozumel, Mexico
- Harvest Caye, Belize
- Coxen Hole, Roatan, Bay Islands, Honduras
- George Town, Grand Cayman
- Cartagena, Colombia
- Colon, Panama
- Panama Canal Transit
- Panama City, Panama
Ports
Miami, Florida - Cozumel, Mexico - Harvest Caye, Belize - Coxen Hole, Roatan, Bay Islands, Honduras - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Panama City, Panama - View more ports
10 Night Panama Canal: Cartagena & Cozumel (Miami To Panama Canal)
2025 sail dates:
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
See Offers |
$1507* |
$1807* |
$2607* |
$2857* |
|
|
|
See Offers |
$1507* |
$1807* |
$2607* |
$2857* |
|
|
|
See Offers |
$1507* |
$1807* |
$2607* |
$2857* |
|
|
|
See Offers |
$1507* |
$1807* |
$2607* |
$2857* |
Ports
- San Pedro (Los Angeles), California
- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puerto Chiapas (Tapachula), Mexico
- Puntarenas, Costa Rica
- PANAMA CITY (FUERTE AMADOR), PANAMA
- Panama Canal Transit
- Oranjestad, Aruba
- Ft. Lauderdale (Port Everglades), Florida
Ports
San Pedro (Los Angeles), California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puntarenas, Costa Rica - PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
$1708* |
$1818* |
$2948* |
N/A |
||
|
|
See Offers |
$1709* |
$1819* |
$2809* |
$3208* |
|
|
|
$1709* |
$1819* |
$2809* |
$3208* |
||
|
|
See Offers |
$1708* |
$1818* |
$2808* |
$3208* |
|
|
|
See Offers |
$1708* |
$1818* |
$2808* |
$3208* |
|
|
|
See Offers |
$1709* |
$1819* |
$2809* |
$3208* |
|
|
|
$1309* |
$1709* |
$2259* |
N/A |
||
|
|
See Offers |
$1309* |
$1437* |
$2259* |
$2756* |
|
|
|
$1309* |
$1437* |
$2259* |
$2756* |
||
|
|
See Offers |
$1309* |
$1437* |
$2259* |
$2756* |
|
|
|
See Offers |
$1309* |
$1437* |
$2259* |
$2756* |
|
|
|
See Offers |
$1309* |
$1437* |
$2259* |
$2756* |
Ports
- Galveston, Texas
- Cozumel, Mexico
- Harvest Caye, Belize
- Coxen Hole, Roatan, Bay Islands, Honduras
- George Town, Grand Cayman
- Cartagena, Colombia
- Colon, Panama
- Panama Canal Transit
- Panama City, Panama
Ports
Galveston, Texas - Cozumel, Mexico - Harvest Caye, Belize - Coxen Hole, Roatan, Bay Islands, Honduras - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Panama City, Panama - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
See Offers |
$1509* |
$1779* |
$2629* |
$2909* |
|
|
|
See Offers |
$1509* |
$1779* |
$2629* |
$2909* |
|
|
|
See Offers |
$1509* |
$1779* |
$2629* |
$2909* |
|
|
|
See Offers |
$1509* |
$1779* |
$2629* |
$2909* |
Ports
- Ft. Lauderdale (Port Everglades), Florida
- Cozumel, Mexico
- Colon, Panama
- Panama Canal Transit
- Manta, Ecuador
- Callao (Lima), Peru
- Iquique, Chile
- Valparaiso (Santiago), Chile
Ports
Ft. Lauderdale (Port Everglades), Florida - Cozumel, Mexico - Colon, Panama - Panama Canal Transit - Manta, Ecuador - Callao (Lima), Peru - Iquique, Chile - Valparaiso (Santiago), Chile - View more ports
17 Night Panama & Scenic South America (Ft. Lauderdale To Santiago)
2025 sail dates:
2026 sail dates: Nov 06
Ports
- GENOA (PORTOFINO), ITALY
- Marseille (Provence), France
- Barcelona, Spain
- Funchal, Madeira
- Philipsburg, St. Maarten
- CRUISE SOUTH ATLANTIC OCEAN
- Miami, Florida
- Cartagena, Colombia
- Colon, Panama
- Panama Canal Transit
- Puntarenas, Costa Rica
- Cabo San Lucas, Mexico
- San Diego, California
- San Pedro (Los Angeles), California
- Seattle, Washington
Ports
GENOA (PORTOFINO), ITALY - Marseille (Provence), France - Barcelona, Spain - Funchal, Madeira - Philipsburg, St. Maarten - CRUISE SOUTH ATLANTIC OCEAN - Miami, Florida - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puntarenas, Costa Rica - Cabo San Lucas, Mexico - San Diego, California - San Pedro (Los Angeles), California - Seattle, Washington - View more ports
Ports
- Miami, Florida
- Cozumel, Mexico
- Costa Maya (Mahahual), Mexico
- Belize City, Belize
- Harvest Caye, Belize
- Santo Tomas De Castilla, Guatemala
- Coxen Hole, Roatan, Bay Islands, Honduras
- Puerto Limon, Costa Rica
- PANAMA CITY (FUERTE AMADOR), PANAMA
- Panama Canal Transit
- Manta, Ecuador
- Guayaquil, Equador
- Salaverry (Trujillo), Peru
- Callao (Lima), Peru
- Coquimbo (La Serena), Chile
- San Antonio, Chile
Ports
Miami, Florida - Cozumel, Mexico - Costa Maya (Mahahual), Mexico - Belize City, Belize - Harvest Caye, Belize - Santo Tomas De Castilla, Guatemala - Coxen Hole, Roatan, Bay Islands, Honduras - Puerto Limon, Costa Rica - PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Manta, Ecuador - Guayaquil, Equador - Salaverry (Trujillo), Peru - Callao (Lima), Peru - Coquimbo (La Serena), Chile - San Antonio, Chile - View more ports
Ports
- Miami, Florida
- Cozumel, Mexico
- Costa Maya (Mahahual), Mexico
- Santo Tomas De Castilla, Guatemala
- Harvest Caye, Belize
- Coxen Hole, Roatan, Bay Islands, Honduras
- Puerto Limon, Costa Rica
- Panama City, Panama
- Panama Canal Transit
- Cartagena, Colombia
- Santa Marta, Colombia
- Oranjestad, Aruba
- Willemstad, Curacao
- Kralendijk, Bonaire
- Port Antonio, Jamaica
Ports
Miami, Florida - Cozumel, Mexico - Costa Maya (Mahahual), Mexico - Santo Tomas De Castilla, Guatemala - Harvest Caye, Belize - Coxen Hole, Roatan, Bay Islands, Honduras - Puerto Limon, Costa Rica - Panama City, Panama - Panama Canal Transit - Cartagena, Colombia - Santa Marta, Colombia - Oranjestad, Aruba - Willemstad, Curacao - Kralendijk, Bonaire - Port Antonio, Jamaica - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
$5699* |
$6199* |
$8799* |
$10299* |
||
|
|
$5220* |
$5580* |
N/A |
N/A |
||
|
|
See Offers |
$5220* |
$5580* |
N/A |
N/A |
|
|
|
See Offers |
$5799* |
$6199* |
N/A |
N/A |
|
|
|
$5799* |
$6199* |
N/A |
N/A |
||
|
|
See Offers |
$5220* |
$5580* |
N/A |
N/A |
|
|
|
See Offers |
$5220* |
$5580* |
N/A |
N/A |
Ports
- Valparaiso (Santiago), Chile
- Iquique, Chile
- Callao (Lima), Peru
- Manta, Ecuador
- Panama Canal Transit
- Colon, Panama
- Cozumel, Mexico
- Ft. Lauderdale (Port Everglades), Florida
Ports
Valparaiso (Santiago), Chile - Iquique, Chile - Callao (Lima), Peru - Manta, Ecuador - Panama Canal Transit - Colon, Panama - Cozumel, Mexico - Ft. Lauderdale (Port Everglades), Florida - View more ports
17 Night Panama & Scenic South America (Santiago To Ft. Lauderdale)
2025 sail dates:
Ports
- Miami, Florida
- Cozumel, Mexico
- Costa Maya (Mahahual), Mexico
- Harvest Caye, Belize
- Santo Tomas De Castilla, Guatemala
- Coxen Hole, Roatan, Bay Islands, Honduras
- Puerto Limon, Costa Rica
- Panama Canal Transit
- Panama City, Panama
Ports
Miami, Florida - Cozumel, Mexico - Costa Maya (Mahahual), Mexico - Harvest Caye, Belize - Santo Tomas De Castilla, Guatemala - Coxen Hole, Roatan, Bay Islands, Honduras - Puerto Limon, Costa Rica - Panama Canal Transit - Panama City, Panama - View more ports
All prices are per person based on double occupancy and do not include port/government fees and gratuities.
More popular cruise lines sailing to Panama Canal, Central America
More popular departure ports with sailings to Panama Canal, Central America
- Ft. Lauderdale (Port Everglades), Florida Cruises to Panama Canal, Central America
- Miami, Florida Cruises to Panama Canal, Central America
- Tampa, Florida Cruises to Panama Canal, Central America
- Seattle, Washington Cruises to Panama Canal, Central America
- New York, New York Cruises to Panama Canal, Central America