Colon, Panama cruises 235 Colon, Panama cruises

Your search Clear selections

Any Destination

All Sail Months

Any Length

Colon, Panama

Any Cruise Line

Any Ship

235 cruises found

Filters Save search

Ports

Miami, Florida
Puerto Limon, Costa Rica
Colon, Panama
Cartagena, Colombia
Oranjestad, Aruba
Perfect Day At Coco Cay, Bahamas

View more ports

Ports

Miami, Florida - Puerto Limon, Costa Rica - Colon, Panama - Cartagena, Colombia - Oranjestad, Aruba - Perfect Day At Coco Cay, Bahamas - View more ports

11 Night Southern Caribbean (Miami Roundtrip)

Explorer of the Seas L

4.0

(2183 Reviews)

2025 sail dates: Jan 05

$4282*

$389/night*

Suite

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2183 Explorer of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	N/A	N/A	N/A	$4282*
See Offers	N/A	N/A	N/A	$4282*
	N/A	N/A	N/A	$4282*
See Offers	N/A	N/A	N/A	$4261*
See Offers	N/A	N/A	N/A	$4283*
	N/A	N/A	N/A	$4282*
	N/A	N/A	N/A	$4278*
See Offers	N/A	N/A	N/A	$4283*
See Offers	N/A	N/A	N/A	$4261*

Ports

Miami, Florida
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puerto Caldera, Costa Rica
Puerto Quetzal, Guatemala
Acapulco, Mexico
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Miami, Florida - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puerto Caldera, Costa Rica - Puerto Quetzal, Guatemala - Acapulco, Mexico - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Pedro (Los Angeles), California - View more ports

16 Night Panama Canal: Mexico & Central America (Miami To Los Angeles)

Norwegian Joy L

4.2

(944 Reviews)

2025 sail dates: Jan 21

$1282*

$80/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 944 Norwegian Joy reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$1282*	$1632*	$1982*	$4912*
See Offers	$1546*	$1896*	$2246*	$2526*
	$1546*	$1896*	$2246*	$2526*
See Offers	$1282*	$1632*	$1982*	$2262*
See Offers	$1282*	$1632*	$1982*	$2262*
See Offers	$1546*	$1896*	$2246*	$2526*
See Offers	$1282*	$1632*	$1982*	$2262*
See Offers	$1282*	$1632*	$1982*	$2262*
See Offers	$1546*	$1896*	$2246*	$2526*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
Ocho Rios, Jamaica

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - Ocho Rios, Jamaica - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1206 Reviews)

2025 sail dates: Feb 16

$1169*

$97/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1206 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1169*	$1748*	$3204*	N/A
See Offers	$1169*	$1344*	$3204*	$3449*
	$1169*	$1344*	$3204*	$3449*
See Offers	$1169*	$1344*	$3204*	$3449*
See Offers	$1169*	$1344*	$3204*	$3448*
See Offers	$1169*	$1344*	$3204*	$3448*
See Offers	$1169*	$1344*	$3204*	$3448*

Ports

Ft. Lauderdale (Port Everglades), Florida
George Town, Grand Cayman
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Pedro (Los Angeles), California - View more ports

16 Night Panama Canal Westward (Ft. Lauderdale To Los Angeles)

Serenade of the Seas L

4.1

(1797 Reviews)

2025 sail dates: Apr 13

$1648*

$103/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1797 Serenade of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$1648*	$1879*	$3329*	$8848*
See Offers	$1648*	$1879*	$3329*	$8848*
	$1655*	$1881*	$3329*	$8848*
See Offers	$1635*	$1861*	$3309*	$8828*
See Offers	$1655*	$1882*	$3329*	$8848*
	$1655*	$1881*	$3329*	$8848*
	$1644*	$1875*	$3325*	$8844*
See Offers	$1655*	$1882*	$3329*	$8848*
See Offers	$1635*	$1861*	$3309*	$8828*

Ports

Galveston, Texas
Cozumel, Mexico
Puerto Limon, Costa Rica
Colon, Panama
Mahogany Bay, Roatan, Bay Islands, Honduras

View more ports

Ports

Galveston, Texas - Cozumel, Mexico - Puerto Limon, Costa Rica - Colon, Panama - Mahogany Bay, Roatan, Bay Islands, Honduras - View more ports

10 Night Panama Canal (Galveston Roundtrip)

Carnival Legend L

3.9

(2185 Reviews)

2025 sail dates: Oct 27, Dec 08

2026 sail dates: Mar 16

$1089*

$109/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2185 Carnival Legend reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1143*	$1343*	$1623*	$3739*
	$1143*	$1343*	$1623*	$3739*
See Offers	$1143*	$1343*	$1623*	$3739*
See Offers	$1143*	$1343*	$1623*	$3739*
	$1143*	$1343*	$1615*	$3731*
	$1089*	$1279*	$1629*	$3299*
	$1089*	$1279*	$1629*	$3299*
See Offers	$1089*	$1279*	$1629*	$3299*
See Offers	$1089*	$1279*	$1629*	$3299*
	$1089*	$1279*	$1621*	$3291*
See Offers	$1339*	$1499*	$1879*	$3079*
	$1339*	$1499*	$1879*	$3079*
See Offers	$1339*	$1499*	$1879*	$3079*
See Offers	$1339*	$1499*	$1879*	$3079*
	$1339*	$1499*	$1871*	$3071*

Ports

Ft. Lauderdale (Port Everglades), Florida
Willemstad, Curacao
Kralendijk, Bonaire
Oranjestad, Aruba
Half Moon Cay, Bahamas (Private Island)
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
Falmouth, Jamaica

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Willemstad, Curacao - Kralendijk, Bonaire - Oranjestad, Aruba - Half Moon Cay, Bahamas (Private Island) - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Falmouth, Jamaica - View more ports

21 Night Southern Caribbean & Panama Canal: Abc Islands (Ft. Lauderdale Roundtrip)

Rotterdam L

4.4

(256 Reviews)

2025 sail dates: Nov 07

$2214*

$105/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 256 Rotterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2214*	$2934*	$3234*	$4894*
See Offers	$2454*	$3174*	$3474*	$5134*
	$2454*	$3174*	$3474*	$5134*
See Offers	$2454*	$3174*	$3474*	$5134*
See Offers	$2454*	$3174*	$3474*	$5134*
See Offers	$2454*	$3174*	$3474*	$5134*
	N/A	N/A	N/A	$5109*
See Offers	$2454*	$3174*	$3474*	$5134*

Ports

Ft. Lauderdale (Port Everglades), Florida
George Town, Grand Cayman
Falmouth, Jamaica
Puerto Limon, Costa Rica
Panama Canal (Cruise Into Canal)
Colon, Panama
Oranjestad, Aruba
Willemstad, Curacao

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Falmouth, Jamaica - Puerto Limon, Costa Rica - Panama Canal (Cruise Into Canal) - Colon, Panama - Oranjestad, Aruba - Willemstad, Curacao - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1889 Reviews)

2025 sail dates: Nov 29

2026 sail dates: Feb 21

$999*

$83/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1889 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$999*	$1239*	$1689*	$4489*
See Offers	$999*	$1029*	$1689*	$2289*
	$999*	$1029*	$1689*	$2289*
See Offers	$999*	$1029*	$1689*	$2289*
See Offers	$999*	$1029*	$1689*	$2289*
See Offers	$999*	$1029*	$1689*	$2289*
See Offers	$999*	$1029*	$1689*	$2289*
	$1508*	$2058*	$2498*	$5069*
See Offers	$1508*	$1550*	$2498*	$3018*
	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*
See Offers	$1508*	$1550*	$2498*	$3018*

Ports

Colon, Panama
Cartagena, Colombia
Oranjestad, Aruba
Kralendijk, Bonaire

View more ports

Ports

Colon, Panama - Cartagena, Colombia - Oranjestad, Aruba - Kralendijk, Bonaire - View more ports

7 Night Southern Caribbean Holiday (Colon Roundtrip)

Serenade of the Seas L

4.1

(1797 Reviews)

2025 sail dates: Dec 27

$1192*

$170/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1797 Serenade of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$1192*	$1242*	$1405*	$1855*
See Offers	$1192*	$1242*	$1405*	$1855*
	$1192*	$1242*	$1405*	$1855*
See Offers	$1193*	$1242*	$1405*	$1855*
See Offers	$1193*	$1242*	$1405*	$1855*
	$1192*	$1242*	$1405*	$1855*
	$1188*	$1238*	$1401*	$1851*
See Offers	$1193*	$1242*	$1405*	$1855*
See Offers	$1193*	$1242*	$1405*	$1855*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Willemstad, Curacao
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Willemstad, Curacao - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1889 Reviews)

2026 sail dates: Jan 04, Jan 16, Mar 17

$1298*

$108/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1889 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1438*	$1788*	$2398*	$4659*
See Offers	$1438*	$1481*	$2398*	$2658*
	$1438*	$1481*	$2398*	$2658*
See Offers	$1438*	$1481*	$2398*	$2658*
See Offers	$1438*	$1481*	$2398*	$2658*
See Offers	$1438*	$1481*	$2398*	$2658*
See Offers	$1438*	$1481*	$2398*	$2658*
	$1298*	$1948*	$2338*	$4919*
See Offers	$1299*	$1336*	$2339*	$2859*
	$1299*	$1336*	$2339*	$2859*
See Offers	$1299*	$1336*	$2339*	$2859*
See Offers	$1298*	$1335*	$2338*	$2858*
See Offers	$1298*	$1335*	$2338*	$2858*
See Offers	$1298*	$1335*	$2338*	$2858*
	$1628*	$2058*	$2488*	$5059*
See Offers	$1628*	$1677*	$2488*	$3008*
	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*

Ports

Colon, Panama
Bocas Del Toro, Panama
San Andres Island (Isla San Andres), Colombia
Coxen Hole, Roatan, Bay Islands, Honduras
Belize City, Belize
Costa Maya (Mahahual), Mexico
Cozumel, Mexico

View more ports

Ports

Colon, Panama - Bocas Del Toro, Panama - San Andres Island (Isla San Andres), Colombia - Coxen Hole, Roatan, Bay Islands, Honduras - Belize City, Belize - Costa Maya (Mahahual), Mexico - Cozumel, Mexico - View more ports

8 Night Mayan Legacies (Colon To Cozumel)

Wind Surf S

4.4

(78 Reviews)

2026 sail dates: Feb 09

$3344*

$418/night*

Oceanview

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 78 Wind Surf reviews

Compare Prices

Inside	Oceanview	Balcony	Suite
N/A	$3344*	N/A	$6444*
N/A	$3408*	N/A	$6508*
N/A	$3408*	N/A	$6508*

71 - 80 of 235

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

Colon, Panama cruises 235 Colon, Panama cruises

Your search Clear selections

235 cruises found

Sort by

Filter by