Panama Canal, Central America Cruises : Best Cruise Prices

Ports

Ft. Lauderdale (Port Everglades), Florida
George Town, Grand Cayman
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Mazatlan, Mexico
San Pedro (Los Angeles), California

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Mazatlan, Mexico - San Pedro (Los Angeles), California - View more ports

16 Night Panama Canal Westward (Ft. Lauderdale To Los Angeles)

Celebrity Summit M

4.1

(2242 Reviews)

2025 sail dates: Apr 17

$1599*

$100/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2242 Celebrity Summit reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1599*	$1871*	$3942*	$7930*
See Offers	$1599*	$2031*	$3942*	$7929*
See Offers	$1599*	$2032*	$3942*	$7930*
	$1599*	$2031*	$3942*	$7929*
	$1599*	$2031*	$3942*	$7929*
See Offers	$1575*	$2007*	$3918*	$7905*
See Offers	$1575*	$2007*	$3918*	$7905*
See Offers	$1599*	$2032*	$3942*	$7930*
See Offers	$1599*	$2031*	$3942*	$7929*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
Princess Cays (Cruise Line Private Island)

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Princess Cays (Cruise Line Private Island) - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1894 Reviews)

2026 sail dates: Oct 30, Nov 23, Dec 05

2027 sail dates: Jan 10, Jan 22

$1097*

$91/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1894 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1147*	$1397*	$2097*	$4399*
See Offers	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*
	$1148*	$1258*	$2098*	$2948*
	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*
	$1197*	$1447*	$2147*	$4499*
See Offers	$1198*	$1318*	$2148*	$2998*
See Offers	$1198*	$1318*	$2148*	$2998*
	$1198*	$1318*	$2148*	$2998*
	$1198*	$1318*	$2148*	$2998*
See Offers	$1198*	$1318*	$2148*	$2998*
See Offers	$1198*	$1318*	$2148*	$2998*
See Offers	$1198*	$1318*	$2148*	$2998*
	$1097*	$1297*	$1947*	$4099*
See Offers	$1098*	$1198*	$1948*	$2748*
See Offers	$1098*	$1198*	$1948*	$2748*
	$1098*	$1198*	$1948*	$2748*
	$1098*	$1198*	$1948*	$2748*
See Offers	$1098*	$1198*	$1948*	$2748*
See Offers	$1098*	$1198*	$1948*	$2748*
See Offers	$1098*	$1198*	$1948*	$2748*
	$1147*	$1397*	$2097*	$4399*
See Offers	$1148*	$1268*	$2098*	$2948*
See Offers	$1148*	$1268*	$2098*	$2948*
	$1148*	$1268*	$2098*	$2948*
	$1148*	$1268*	$2098*	$2948*
See Offers	$1148*	$1268*	$2098*	$2948*
See Offers	$1148*	$1268*	$2098*	$2948*
See Offers	$1148*	$1268*	$2098*	$2948*
	$1147*	$1397*	$2097*	$4399*
See Offers	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*
	$1148*	$1258*	$2098*	$2948*
	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*
See Offers	$1148*	$1258*	$2098*	$2948*

Ports

San Diego, California
Cabo San Lucas, Mexico
Acapulco, Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
Panama City, Panama
Panama Canal Transit
Cartagena, Colombia
Miami, Florida

View more ports

Ports

San Diego, California - Cabo San Lucas, Mexico - Acapulco, Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama City, Panama - Panama Canal Transit - Cartagena, Colombia - Miami, Florida - View more ports

15 Night Panama Canal: Mexico & Costa Rica (San Diego To Miami)

Norwegian Star L

3.6

(2055 Reviews)

2027 sail dates: Apr 03

$2113*

$141/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2055 Norwegian Star reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$2113*	$2613*	$3663*	$4913*
See Offers	$2113*	$2613*	$3663*	$4363*
See Offers	$2113*	$2613*	$3663*	$4363*
	$2112*	$2612*	$3662*	$4362*
	$2113*	$2613*	$3663*	$4363*
See Offers	$2113*	$2613*	$3663*	$4363*
See Offers	$2113*	$2613*	$3663*	$4363*
See Offers	$2113*	$2613*	$3663*	$4363*
See Offers	$2113*	$2613*	$3663*	$4363*
See Offers	$2113*	$2613*	$3663*	$4363*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Willemstad, Curacao
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Cristobal, Panama
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Willemstad, Curacao - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Cristobal, Panama - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1210 Reviews)

2025 sail dates: Feb 04

$1317*

$110/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1210 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1317*	$1430*	N/A	N/A
See Offers	$1318*	$1431*	N/A	N/A
See Offers	$1318*	$1431*	N/A	$2698*
	$1318*	$1431*	N/A	$2698*
	$1318*	$1431*	N/A	N/A
See Offers	$1318*	$1431*	N/A	$2698*
See Offers	$1318*	$1431*	N/A	N/A
See Offers	$1318*	$1431*	N/A	$2698*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Grand Turk Island
Amber Cove (Puerto Plata), Dominican Republic
Nassau, Bahamas
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California
Catalina Island, California
Vancouver (Canada Place), British Columbia

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Amber Cove (Puerto Plata), Dominican Republic - Nassau, Bahamas - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Catalina Island, California - Vancouver (Canada Place), British Columbia - View more ports

26 Night Eastern Caribbean Explorer & Panama Canal (Ft. Lauderdale To Vancouver)

Eurodam L

4.1

(1102 Reviews)

2026 sail dates: Mar 29

$3217*

$124/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1102 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3217*	$3427*	$4727*	$7937*
See Offers	$3217*	$3427*	$4727*	$7937*
See Offers	$3217*	$3427*	$4727*	$7937*
	$3217*	$3427*	$4727*	$7937*
See Offers	$3217*	$3427*	$4727*	$7937*
	$3217*	$3427*	$4727*	$7937*
See Offers	$3217*	$3427*	$4727*	$7937*
See Offers	$3217*	$3427*	$4727*	$7937*
See Offers	$3217*	$3427*	$4727*	$7937*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Grand Turk Island
Amber Cove (Puerto Plata), Dominican Republic
Nassau, Bahamas
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Amber Cove (Puerto Plata), Dominican Republic - Nassau, Bahamas - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

22 Night Eastern Caribbean Explorer & Panama Canal (Ft. Lauderdale To San Diego)

Eurodam L

4.1

(1102 Reviews)

2026 sail dates: Mar 29

$2993*

$136/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1102 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2993*	$3178*	$4398*	$7413*
See Offers	$2993*	$3178*	$4398*	$7413*
See Offers	$2993*	$3178*	$4398*	$7413*
	$2993*	$3178*	$4398*	$7413*
See Offers	$2993*	$3178*	$4398*	$7413*
	$2993*	$3178*	$4398*	$7413*
See Offers	$2993*	$3178*	$4398*	$7413*
See Offers	$2993*	$3178*	$4398*	$7413*
See Offers	$2993*	$3178*	$4398*	$7413*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California
Catalina Island, California
Vancouver (Canada Place), British Columbia
Seattle, Washington

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Catalina Island, California - Vancouver (Canada Place), British Columbia - Seattle, Washington - View more ports

20 Night Panama Canal (Ft. Lauderdale To Seattle)

Eurodam L

4.1

(1102 Reviews)

2026 sail dates: Apr 05

$2799*

$140/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1102 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2799*	$2949*	$4099*	$6599*
See Offers	$2799*	$2949*	$4099*	$6599*
See Offers	$2799*	$2949*	$4099*	$6599*
	$2799*	$2949*	$4099*	$6599*
See Offers	$2799*	$2949*	$4099*	$6599*
	$2799*	$2949*	$4099*	$6599*
See Offers	$2799*	$2949*	$4099*	$6599*
See Offers	$2799*	$2949*	$4099*	$6599*
See Offers	$2799*	$2949*	$4099*	$6599*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

15 Night Panama Canal (Ft. Lauderdale To San Diego)

Eurodam L

4.1

(1102 Reviews)

2026 sail dates: Apr 05

$2400*

$160/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1102 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2400*	$2550*	$3575*	$5810*
See Offers	$2400*	$2550*	$3575*	$5810*
See Offers	$2400*	$2550*	$3575*	$5810*
	$2400*	$2550*	$3575*	$5810*
See Offers	$2400*	$2550*	$3575*	$5810*
	$2400*	$2550*	$3575*	$5810*
See Offers	$2400*	$2550*	$3575*	$5810*
See Offers	$2400*	$2550*	$3575*	$5810*
See Offers	$2400*	$2550*	$3575*	$5810*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California
Catalina Island, California
Vancouver (Canada Place), British Columbia

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Catalina Island, California - Vancouver (Canada Place), British Columbia - View more ports

19 Night Panama Canal (Ft. Lauderdale To Vancouver)

Eurodam L

4.1

(1102 Reviews)

2026 sail dates: Apr 05

$2645*

$139/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1102 Eurodam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2645*	$2795*	$3925*	$6355*
See Offers	$2645*	$2795*	$3925*	$6355*
See Offers	$2645*	$2795*	$3925*	$6355*
	$2645*	$2795*	$3925*	$6355*
See Offers	$2645*	$2795*	$3925*	$6355*
	$2645*	$2795*	$3925*	$6355*
See Offers	$2645*	$2795*	$3925*	$6355*
See Offers	$2645*	$2795*	$3925*	$6355*
See Offers	$2645*	$2795*	$3925*	$6355*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Willemstad, Curacao
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Willemstad, Curacao - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1894 Reviews)

2026 sail dates: Jan 04, Jan 16, Mar 17

$1297*

$108/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1894 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1437*	$1787*	$2297*	$4749*
See Offers	$1438*	$1481*	$2298*	$2658*
See Offers	$1438*	$1481*	$2298*	$2658*
	$1438*	$1481*	$2298*	$2658*
	$1438*	$1481*	$2298*	$2658*
See Offers	$1438*	$1481*	$2298*	$2658*
See Offers	$1438*	$1481*	$2298*	$2658*
See Offers	$1438*	$1481*	$2298*	$2658*
	$1297*	$1947*	$2337*	$4919*
See Offers	$1299*	$1336*	$2339*	$2859*
See Offers	$1298*	$1335*	$2338*	$2858*
	$1298*	$1335*	$2338*	$2858*
	$1299*	$1336*	$2339*	$2859*
See Offers	$1298*	$1335*	$2338*	$2858*
See Offers	$1299*	$1336*	$2339*	$2859*
See Offers	$1298*	$1335*	$2338*	$2858*
	$1627*	$2057*	$2487*	$5059*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
	$1628*	$1677*	$2488*	$3008*
	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*
See Offers	$1628*	$1677*	$2488*	$3008*

Panama Canal, Central America cruises 342 Panama Canal, Central America Cruises Found

Your search Clear selections

342 cruises found

Sort by

Filter by

More popular cruise lines sailing to Panama Canal, Central America

More popular departure ports with sailings to Panama Canal, Central America