Colon, Panama cruises 181 Colon, Panama cruises

Your search Clear selections

Any Destination

All Sail Months

Any Length

Colon, Panama

Any Cruise Line

Any Ship

181 cruises found

Filters Save search

Ports

Tampa, Florida
George Town, Grand Cayman
Colon, Panama
Puerto Limon, Costa Rica
Cozumel, Mexico

View more ports

Ports

Tampa, Florida - George Town, Grand Cayman - Colon, Panama - Puerto Limon, Costa Rica - Cozumel, Mexico - View more ports

9 Night Western Caribbean (Tampa Roundtrip)

Serenade of the Seas L

4.1

(1781 Reviews)

2024 sail dates: Oct 11, Nov 08, Dec 06

2025 sail dates: Jan 03, Feb 28

$820*

$91/night*

Oceanview

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1781 Serenade of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$952*	$888*	N/A	$3029*
See Offers	$951*	$887*	$1268*	$3028*
	$964*	$900*	N/A	$3041*
See Offers	$951*	$887*	$1268*	$3028*
See Offers	$951*	$887*	$1268*	$3028*
See Offers	$952*	$888*	N/A	$3029*
See Offers	$952*	$888*	N/A	$3029*
See Offers	$952*	$888*	N/A	$3029*
	$951*	$887*	$1268*	$3028*
See Offers	$952*	$888*	N/A	$3029*
See Offers	$822*	$997*	$1339*	$3859*
See Offers	$821*	$873*	$1338*	$3859*
	$834*	$1009*	$1351*	$3871*
See Offers	$821*	$873*	$1338*	$3859*
See Offers	$821*	$873*	$1338*	$3859*
See Offers	$822*	$997*	$1339*	$3859*
See Offers	$822*	$790*	$1119*	$3859*
See Offers	$822*	$790*	$1119*	$3859*
	$821*	$873*	$1338*	$3859*
See Offers	$822*	$997*	$1339*	$3859*
See Offers	$800*	$820*	N/A	$3931*
See Offers	$916*	$819*	N/A	$3930*
	$929*	$832*	N/A	$3943*
See Offers	$916*	$819*	N/A	$3930*
See Offers	$916*	$819*	N/A	$3930*
See Offers	$917*	$820*	N/A	$3931*
See Offers	$917*	$820*	N/A	$3931*
See Offers	$917*	$820*	N/A	$3931*
	$916*	$819*	N/A	$3930*
See Offers	$631*	$562*	N/A	$3931*
See Offers	$799*	$1089*	$1509*	$6938*
See Offers	$798*	$1088*	$1508*	$6937*
	$811*	$1101*	$1521*	$6950*
See Offers	$798*	$1088*	$1508*	$6937*
See Offers	$798*	$1088*	$1508*	$6937*
See Offers	$799*	$1089*	$1509*	$6938*
See Offers	$799*	$1089*	$1509*	$6938*
See Offers	$799*	$1089*	$1509*	$6938*
	$798*	$1088*	$1508*	$6937*
See Offers	$799*	$1089*	$1509*	$6938*
See Offers	$749*	$799*	$1938*	$3585*
See Offers	$749*	$798*	$1937*	$3584*
	$761*	$811*	$1950*	$3597*
See Offers	$749*	$798*	$1937*	$3584*
See Offers	$749*	$798*	$1937*	$3584*
See Offers	$749*	$799*	$1938*	$3585*
See Offers	$749*	$799*	$1938*	$3585*
See Offers	$749*	$799*	$1938*	$3585*
	$749*	$798*	$1937*	$3584*
See Offers	$749*	$799*	$1938*	$3585*

Ports

Miami, Florida
Puerto Limon, Costa Rica
Colon, Panama
Cartagena, Colombia
Oranjestad, Aruba
Willemstad, Curacao

View more ports

Ports

Miami, Florida - Puerto Limon, Costa Rica - Colon, Panama - Cartagena, Colombia - Oranjestad, Aruba - Willemstad, Curacao - View more ports

11 Night Southern Caribbean (Miami Roundtrip)

Explorer of the Seas L

4.0

(2164 Reviews)

2024 sail dates: Nov 24

2025 sail dates: Mar 09, Mar 30

$929*

$84/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2164 Explorer of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$989*	$1348*	$1669*	$3499*
See Offers	$1148*	$1348*	$1552*	$3499*
	$1001*	$1360*	$1681*	$3436*
See Offers	$1148*	$1348*	$1552*	$3499*
See Offers	$1148*	$1348*	$1552*	$3499*
See Offers	$989*	$1348*	$1669*	$3424*
See Offers	$989*	$1348*	$1564*	$3424*
See Offers	$989*	$1348*	$1564*	$3424*
	$1148*	$1348*	$1552*	$3499*
See Offers	$989*	$1348*	$1669*	$3499*
See Offers	$929*	$1068*	$1859*	$5574*
See Offers	$946*	$1068*	$1859*	$5574*
	$958*	$1341*	$1871*	$5586*
See Offers	$946*	$1068*	$1859*	$5574*
See Offers	$946*	$1068*	$1859*	$5574*
See Offers	$946*	$1329*	$1859*	$5574*
See Offers	$946*	$1329*	$1859*	$5574*
See Offers	$946*	$1329*	$1859*	$5574*
	$946*	$1068*	$1859*	$5574*
See Offers	$929*	$1068*	$1859*	$5574*
See Offers	$1066*	$1142*	$2049*	$4997*
See Offers	$1066*	$1142*	$2048*	$4996*
	$1078*	$1511*	$2061*	$5009*
See Offers	$1066*	$1142*	$2048*	$4996*
See Offers	$1066*	$1142*	$2048*	$4996*
See Offers	$1066*	$1499*	$2049*	$4997*
See Offers	$1066*	$1499*	$2049*	$4997*
See Offers	$1066*	$1499*	$2049*	$4997*
	$1066*	$1142*	$2048*	$4996*
See Offers	$1066*	$1499*	$2049*	$4997*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Kralendijk, Bonaire
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Kralendijk, Bonaire - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1172 Reviews)

2025 sail dates: Jan 11, Jan 23

$847*

$71/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1172 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$847*	$1397*	$1897*	$5078*
See Offers	$849*	$990*	$1899*	$2299*
See Offers	$848*	$989*	$1898*	$2298*
See Offers	$848*	$989*	$1898*	$2298*
See Offers	$848*	$989*	$1898*	$2298*
See Offers	$848*	$989*	$1898*	$2298*
See Offers	$848*	$989*	$1898*	$2298*
See Offers	$848*	$989*	$1898*	$2298*
	$860*	$1001*	$1910*	$2310*
See Offers	$848*	$989*	$1898*	$2298*
	$848*	$989*	$1898*	$2298*
	$847*	$1397*	$1797*	$4817*
See Offers	$849*	$977*	$1799*	$2399*
See Offers	$848*	$976*	$1798*	$2398*
See Offers	$848*	$976*	$1798*	$2398*
See Offers	$848*	$976*	$1798*	$2398*
See Offers	$848*	$976*	$1798*	$1989*
See Offers	$848*	$976*	$1798*	$1989*
	$860*	$988*	$1810*	$2001*
See Offers	$848*	$976*	$1798*	$1989*
	$848*	$976*	$1798*	$2398*

Ports

Ft. Lauderdale (Port Everglades), Florida
Kralendijk, Bonaire
Oranjestad, Aruba
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Kralendijk, Bonaire - Oranjestad, Aruba - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Emerald Princess L

4.0

(1172 Reviews)

2024 sail dates: Dec 06

2025 sail dates: Feb 28

$597*

$50/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1172 Emerald Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$597*	$979*	$1297*	$3698*
See Offers	$598*	$698*	$1298*	$1798*
See Offers	$598*	$698*	$1298*	$1798*
See Offers	$598*	$698*	$1298*	$1798*
See Offers	$598*	$698*	$1298*	$1798*
See Offers	$538*	$628*	$1168*	$1618*
See Offers	$538*	$628*	$1168*	$1618*
	$550*	$640*	$1180*	$1630*
See Offers	$598*	$698*	$1298*	$1798*
	$598*	$698*	$1298*	$1798*
	$697*	$1097*	$1547*	$4696*
See Offers	$698*	$803*	$1548*	$2098*
See Offers	$698*	$803*	$1548*	$2098*
See Offers	$698*	$803*	$1548*	$2098*
See Offers	$698*	$803*	$1548*	$2098*
See Offers	$628*	$722*	$1393*	$1888*
See Offers	$628*	$722*	$1393*	$1888*
	$640*	$734*	$1405*	$1900*
See Offers	$698*	$803*	$1548*	$2098*
	$698*	$803*	$1548*	$2098*

Ports

Miami, Florida
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puerto Caldera, Costa Rica
Puerto Quetzal, Guatemala
Acapulco, Mexico
Cabo San Lucas, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Miami, Florida - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puerto Caldera, Costa Rica - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - San Pedro (Los Angeles), California - View more ports

15 Night Panama Canal: Mexico & Costa Rica (Miami To Los Angeles)

Norwegian Encore XL

4.3

(657 Reviews)

2025 sail dates: Nov 29

$1449*

$97/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 657 Norwegian Encore reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$1449*	$2099*	$2799*	$8149*
See Offers	$1449*	$2099*	$2799*	$3349*
See Offers	$1449*	$2099*	$2799*	$3349*
See Offers	$1449*	$2099*	$2799*	$3349*
See Offers	$1449*	$2099*	$2799*	$3349*
See Offers	$1449*	$2099*	$2799*	$3349*
See Offers	$1449*	$2099*	$2799*	$3349*
	$1449*	$2099*	$2799*	$3349*
	$1461*	$2111*	$2811*	$3361*
See Offers	$1449*	$2099*	$2799*	$3349*

Ports

Tampa, Florida
Puerto Limon, Costa Rica
Colon, Panama
George Town, Grand Cayman

View more ports

Ports

Tampa, Florida - Puerto Limon, Costa Rica - Colon, Panama - George Town, Grand Cayman - View more ports

8 Night Panama Canal - Partial Transit (Tampa Roundtrip)

Carnival Miracle L

4.0

(2718 Reviews)

2026 sail dates: Jan 17, Mar 14

$889*

$111/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2718 Carnival Miracle reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$889*	$999*	$1099*	$1949*
	$901*	$1011*	$1111*	$1961*
See Offers	$889*	$999*	$1099*	$1949*
See Offers	$889*	$999*	$1099*	$1949*
	$889*	$999*	$1099*	$1949*
See Offers	$919*	$1039*	$1179*	$2079*
	$931*	$1051*	$1191*	$2091*
See Offers	$919*	$1039*	$1179*	$2079*
See Offers	$919*	$1039*	$1179*	$2079*
	$919*	$1039*	$1179*	$2079*

Ports

Galveston, Texas
Cozumel, Mexico
Puerto Limon, Costa Rica
Colon, Panama
Mahogany Bay, Roatan, Bay Islands, Honduras

View more ports

Ports

Galveston, Texas - Cozumel, Mexico - Puerto Limon, Costa Rica - Colon, Panama - Mahogany Bay, Roatan, Bay Islands, Honduras - View more ports

10 Night Panama Canal (Galveston Roundtrip)

Carnival Miracle L

4.0

(2718 Reviews)

2024 sail dates: Nov 15, Dec 27

2025 sail dates: Feb 07

$1089*

$109/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2718 Carnival Miracle reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	N/A	N/A	N/A	$4129*
	$1251*	$1471*	$1691*	$4141*
See Offers	N/A	N/A	N/A	$4129*
See Offers	N/A	N/A	N/A	$4129*
	N/A	N/A	N/A	$4129*
See Offers	$1589*	$2019*	$2389*	N/A
	$1601*	$2031*	$2401*	N/A
See Offers	$1589*	$2019*	$2389*	N/A
See Offers	$1589*	$2019*	$2389*	N/A
	$1589*	$2019*	$2389*	N/A
See Offers	$1089*	$1279*	$1599*	$4039*
	$1101*	$1291*	$1611*	$4051*
See Offers	$1089*	$1279*	$1599*	$4039*
See Offers	$1089*	$1279*	$1599*	$4039*
	$1089*	$1279*	$1599*	$4039*

Ports

Tampa, Florida
George Town, Grand Cayman
Cartagena, Colombia
Colon, Panama
Puerto Limon, Costa Rica
Cozumel, Mexico

View more ports

Ports

Tampa, Florida - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Puerto Limon, Costa Rica - Cozumel, Mexico - View more ports

12 Night Ultimate Caribbean & The Americas (Tampa Roundtrip)

Celebrity Constellation M

4.0

(1004 Reviews)

2024 sail dates: Nov 30

$986*

$82/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1004 Celebrity Constellation reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	N/A	$2009*	$2679*	$4284*
	$986*	$1047*	$1394*	$4284*
See Offers	$985*	$1046*	$1393*	$4283*
See Offers	$985*	$1046*	$1393*	$4283*
See Offers	$986*	$1047*	$1394*	$4284*
See Offers	$986*	$1047*	$1394*	$4284*
See Offers	$986*	$1047*	$1394*	$4284*
	$985*	$1046*	$1393*	$4283*
See Offers	$986*	$1047*	$1394*	$4284*
See Offers	$985*	$1046*	$1393*	$4283*
	N/A	N/A	N/A	$4296*

Ports

Miami, Florida
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puerto Caldera, Costa Rica
Puerto Quetzal, Guatemala
Manzanillo, Mexico
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Pedro (Los Angeles), California

View more ports

Ports

Miami, Florida - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puerto Caldera, Costa Rica - Puerto Quetzal, Guatemala - Manzanillo, Mexico - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Pedro (Los Angeles), California - View more ports

15 Night Panama Canal: Mexico & Colombia (Miami To Los Angeles)

Norwegian Bliss XL

4.1

(1294 Reviews)

2025 sail dates: Feb 22

$1199*

$80/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1294 Norwegian Bliss reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$1199*	$1799*	$2469*	$9399*
See Offers	$1199*	$1799*	$2469*	$2929*
See Offers	$1199*	$1799*	$2469*	$2929*
See Offers	$1199*	$1799*	$2469*	$2929*
See Offers	$1199*	$1799*	$2469*	$2929*
See Offers	$1199*	$1799*	$2469*	$2929*
See Offers	$1199*	$1799*	$2469*	$2929*
See Offers	$1199*	$1799*	$2469*	$2929*
	$1199*	$1799*	$2469*	$2929*
	$1211*	$1811*	$2481*	$2941*
See Offers	$1199*	$1799*	$2469*	$2929*

Ports

Ft. Lauderdale (Port Everglades), Florida
Oranjestad, Aruba
Kralendijk, Bonaire
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Oranjestad, Aruba - Kralendijk, Bonaire - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

12 Night Panama Canal With Costa Rica & Caribbean (Ft. Lauderdale Roundtrip)

Caribbean Princess L

3.9

(1869 Reviews)

2025 sail dates: Dec 11

2026 sail dates: Jan 28

$747*

$62/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1869 Caribbean Princess reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$747*	$1047*	$1497*	$4098*
See Offers	$748*	$785*	$1498*	$2098*
See Offers	$748*	$785*	$1498*	$2098*
See Offers	$748*	$785*	$1498*	$2098*
See Offers	$748*	$785*	$1498*	$2098*
See Offers	$748*	$785*	$1498*	$2098*
See Offers	$748*	$785*	$1498*	$2098*
	$760*	$797*	$1510*	$2110*
See Offers	$748*	$785*	$1498*	$2098*
	$748*	$785*	$1498*	$2098*
	$1097*	$1547*	$1997*	$4498*
See Offers	$1098*	$1148*	$1998*	$2498*
See Offers	$1098*	$1148*	$1998*	$2498*
See Offers	$1098*	$1148*	$1998*	$2498*
See Offers	$1098*	$1148*	$1998*	$2498*
See Offers	$1098*	$1148*	$1998*	$2498*
See Offers	$1098*	$1148*	$1998*	$2498*
	$1110*	$1160*	$2010*	$2510*
See Offers	$1098*	$1148*	$1998*	$2498*
	$1098*	$1148*	$1998*	$2498*

1 - 10 of 181

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

Colon, Panama cruises 181 Colon, Panama cruises

Your search Clear selections

181 cruises found

Sort by

Filter by