Panama Canal, Central America cruises 385 Panama Canal, Central America Cruises Found
Your search Clear selections
385 cruises found
Sort by
Filter by
Ports
- Miami, Florida
- George Town, Grand Cayman
- Cartagena, Colombia
- Panama Canal (Cruise Into Canal)
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Ports
Miami, Florida - George Town, Grand Cayman - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Harvest Caye, Belize - Cozumel, Mexico - View more ports
11 Night Panama Canal: Mexico Costa Rica & Belize (Miami Roundtrip)
2025 sail dates:
Ports
- New York, New York
- Ft. Lauderdale (Port Everglades), Florida
- Philipsburg, St. Maarten
- Castries, St. Lucia
- Bridgetown, Barbados
- Devils Island, French Guiana
- Cruise Amazon River
- CRUISE BARRA NORTE RIVER
- Macapa, Brazil
- Cross The Equator
- Santarem, Brazil
- Boca Da Valeria, Brazil
- Manaus, Brazil
- Parintins, Brazil
- Alter Do Chao, Brazil
- Port of Spain
- Willemstad, Curacao
- Oranjestad, Aruba
Ports
New York, New York - Ft. Lauderdale (Port Everglades), Florida - Philipsburg, St. Maarten - Castries, St. Lucia - Bridgetown, Barbados - Devils Island, French Guiana - Cruise Amazon River - CRUISE BARRA NORTE RIVER - Macapa, Brazil - Cross The Equator - Santarem, Brazil - Boca Da Valeria, Brazil - Manaus, Brazil - Parintins, Brazil - Alter Do Chao, Brazil - Port of Spain - Willemstad, Curacao - Oranjestad, Aruba - View more ports
Ports
- Ft. Lauderdale (Port Everglades), Florida
- Cartagena, Colombia
- Colon, Panama
- Panama Canal (Cruise Into Canal)
- Oranjestad, Aruba
- Willemstad, Curacao
- Kralendijk, Bonaire
Ports
Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Oranjestad, Aruba - Willemstad, Curacao - Kralendijk, Bonaire - View more ports
11 Night Panama Canal & Southern Caribbean (Ft. Lauderdale Roundtrip)
2026 sail dates:
2027 sail dates: Mar 08
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
$2211* |
$2411* |
$2751* |
$7277* |
||
|
|
$2211* |
$2411* |
$2751* |
$7276* |
||
|
|
See Offers |
$2211* |
$2411* |
$2751* |
$7277* |
|
|
|
See Offers |
$2211* |
$2411* |
$2751* |
$7277* |
|
|
|
$2211* |
$2411* |
$2751* |
$7276* |
||
|
|
$2211* |
$2411* |
$2751* |
$7276* |
||
|
|
See Offers |
$2211* |
$2411* |
$2751* |
$7277* |
|
|
See Offers |
$2211* |
$2411* |
$2751* |
$7277* |
|
|
|
$2212* |
$2412* |
$2752* |
$7278* |
||
|
|
$2212* |
$2412* |
$2752* |
$7277* |
||
|
|
See Offers |
$2212* |
$2412* |
$2752* |
$7278* |
|
|
|
See Offers |
$2212* |
$2412* |
$2752* |
$7278* |
|
|
|
$2212* |
$2412* |
$2752* |
$7277* |
||
|
|
$2212* |
$2412* |
$2752* |
$7277* |
||
|
|
See Offers |
$2212* |
$2412* |
$2752* |
$7278* |
|
|
|
See Offers |
$2212* |
$2412* |
$2752* |
$7278* |
Ports
- Tampa, Florida
- George Town, Grand Cayman
- Cartagena, Colombia
- Colon, Panama
- Panama Canal (Cruise Into Canal)
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Ports
Tampa, Florida - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - Harvest Caye, Belize - Cozumel, Mexico - View more ports
11 Night Panama Canal Partial Transit: Mexico Costa Rica & Belize (Tampa Roundtrip)
2026 sail dates:
2027 sail dates: Mar 08
Ports
- San Pedro (Los Angeles), California
- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puerto Chiapas (Tapachula), Mexico
- Puntarenas, Costa Rica
- PANAMA CITY (FUERTE AMADOR), PANAMA
- Panama Canal Transit
- Oranjestad, Aruba
- Ft. Lauderdale (Port Everglades), Florida
Ports
San Pedro (Los Angeles), California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puntarenas, Costa Rica - PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports
Ports
- Tampa, Florida
- Cozumel, Mexico
- Harvest Caye, Belize
- Puerto Limon, Costa Rica
- Panama Canal (Cruise Into Canal)
- Colon, Panama
- Willemstad, Curacao
- Oranjestad, Aruba
- CABO ROJO, DOMINICAN REPUBLIC
- Great Stirrup Cay (Cruise Line Private Island), Bahamas
Ports
Tampa, Florida - Cozumel, Mexico - Harvest Caye, Belize - Puerto Limon, Costa Rica - Panama Canal (Cruise Into Canal) - Colon, Panama - Willemstad, Curacao - Oranjestad, Aruba - CABO ROJO, DOMINICAN REPUBLIC - Great Stirrup Cay (Cruise Line Private Island), Bahamas - View more ports
14 Night Panama Canal: Mexico Bahamas & Costa Rica (Tampa Roundtrip)
2026 sail dates:
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
See Offers |
$2456* |
$3106* |
$4506* |
$9006* |
|
|
|
See Offers |
$2428* |
$3106* |
$4498* |
$9006* |
|
|
|
$2428* |
$3106* |
$4498* |
$9006* |
||
|
|
See Offers |
$2456* |
$3106* |
$4506* |
$9006* |
|
|
|
See Offers |
$2456* |
$3106* |
$4506* |
$9006* |
|
|
|
$2428* |
$3106* |
$4498* |
$9006* |
||
|
|
$2428* |
$3106* |
$4498* |
$9006* |
||
|
|
See Offers |
$2456* |
$3106* |
$4506* |
$9006* |
|
|
|
See Offers |
$2456* |
$3106* |
$4506* |
$9006* |
Ports
- Miami, Florida
- George Town, Grand Cayman
- Cartagena, Colombia
- Panama Canal Transit
- Puntarenas, Costa Rica
- Puerto Corinto, Nicaragua
- Puerto Quetzal, Guatemala
- Acapulco, Mexico
- Cabo San Lucas, Mexico
- San Diego, California
- San Pedro (Los Angeles), California
Ports
Miami, Florida - George Town, Grand Cayman - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Corinto, Nicaragua - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - San Diego, California - San Pedro (Los Angeles), California - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
N/A |
N/A |
N/A |
$9899* |
||
|
|
N/A |
N/A |
N/A |
$9899* |
||
|
|
See Offers |
N/A |
N/A |
N/A |
$9899* |
|
|
|
N/A |
N/A |
N/A |
$9899* |
Ports
- Southampton (London), England
- New York, New York
- Oranjestad, Aruba
- Panama Canal Transit
- Puerto Vallarta, Mexico
- San Pedro (Los Angeles), California
Ports
Southampton (London), England - New York, New York - Oranjestad, Aruba - Panama Canal Transit - Puerto Vallarta, Mexico - San Pedro (Los Angeles), California - View more ports
Ports
- New York, New York
- Oranjestad, Aruba
- Panama Canal Transit
- Puerto Vallarta, Mexico
- San Pedro (Los Angeles), California
Ports
New York, New York - Oranjestad, Aruba - Panama Canal Transit - Puerto Vallarta, Mexico - San Pedro (Los Angeles), California - View more ports
Ports
- Ft. Lauderdale (Port Everglades), Florida
- Grand Turk Island
- Bridgetown, Barbados
- Fortaleza, Brazil
- Salvador De Bahia, Brazil
- Buzios, Brazil
- Rio De Janeiro, Brazil
- Santos (Sao Paulo), Brazil
- Montevideo, Uruguay
- Buenos Aires, Argentina
- Puerto Madryn, Argentina
- Ushuaia, Tierra Del Fuego, Argentina
- Cruise Cape Horn
- Punta Arenas, Chile
- CRUISE AMALIA OR BRUJO GLACIER
- Puerto Montt, Chile
- San Antonio, Chile
- Coquimbo (La Serena), Chile
- Arica, Chile
- Callao (Lima), Peru
- Manta, Ecuador
- Fuerte Amador, Panama
- Panama Canal Transit
- Oranjestad, Aruba
Ports
Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - Bridgetown, Barbados - Fortaleza, Brazil - Salvador De Bahia, Brazil - Buzios, Brazil - Rio De Janeiro, Brazil - Santos (Sao Paulo), Brazil - Montevideo, Uruguay - Buenos Aires, Argentina - Puerto Madryn, Argentina - Ushuaia, Tierra Del Fuego, Argentina - Cruise Cape Horn - Punta Arenas, Chile - CRUISE AMALIA OR BRUJO GLACIER - Puerto Montt, Chile - San Antonio, Chile - Coquimbo (La Serena), Chile - Arica, Chile - Callao (Lima), Peru - Manta, Ecuador - Fuerte Amador, Panama - Panama Canal Transit - Oranjestad, Aruba - View more ports
Ports
- San Pedro (Los Angeles), California
- Cabo San Lucas, Mexico
- Puerto Vallarta, Mexico
- Puerto Quetzal, Guatemala
- Puntarenas, Costa Rica
- Panama Canal Transit
- Cartagena, Colombia
- George Town, Grand Cayman
- Miami, Florida
Ports
San Pedro (Los Angeles), California - Cabo San Lucas, Mexico - Puerto Vallarta, Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Cartagena, Colombia - George Town, Grand Cayman - Miami, Florida - View more ports
16 Night Ultimate Panama Canal Transit (Los Angeles To Miami)
2027 sail dates:
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
N/A |
N/A |
N/A |
$9999* |
||
|
|
N/A |
N/A |
N/A |
$9999* |
||
|
|
See Offers |
N/A |
N/A |
N/A |
$9999* |
|
|
|
N/A |
N/A |
N/A |
$9999* |
Ports
- Miami, Florida
- Costa Maya (Mahahual), Mexico
- Harvest Caye, Belize
- Coxen Hole, Roatan, Bay Islands, Honduras
- George Town, Grand Cayman
- Ocho Rios, Jamaica
- Puerto Limon, Costa Rica
- Cartagena, Colombia
- Colon, Panama
- Panama City, Panama
- Panama Canal Transit
Ports
Miami, Florida - Costa Maya (Mahahual), Mexico - Harvest Caye, Belize - Coxen Hole, Roatan, Bay Islands, Honduras - George Town, Grand Cayman - Ocho Rios, Jamaica - Puerto Limon, Costa Rica - Cartagena, Colombia - Colon, Panama - Panama City, Panama - Panama Canal Transit - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
N/A |
N/A |
N/A |
$8799* |
||
|
|
N/A |
N/A |
N/A |
$8799* |
||
|
|
See Offers |
N/A |
N/A |
N/A |
$8799* |
|
|
|
N/A |
N/A |
N/A |
$8799* |
All prices are per person based on double occupancy and do not include port/government fees and gratuities.
More popular cruise lines sailing to Panama Canal, Central America
More popular departure ports with sailings to Panama Canal, Central America
- Ft. Lauderdale (Port Everglades), Florida Cruises to Panama Canal, Central America
- Miami, Florida Cruises to Panama Canal, Central America
- Tampa, Florida Cruises to Panama Canal, Central America
- Seattle, Washington Cruises to Panama Canal, Central America
- New York, New York Cruises to Panama Canal, Central America