Panama Canal, Central America cruises 345 Panama Canal, Central America Cruises Found
Your search Clear selections
345 cruises found
Sort by
Filter by
Ports
- Puntarenas, Costa Rica
- Puerto Quepos, Costa Rica
- PLAYA MUERTO, DARIEN, PANAMA
- Fuerte Amador, Panama
- Panama Canal Transit
- San Blas Islands, Panama
- Colon, Panama
Ports
Puntarenas, Costa Rica - Puerto Quepos, Costa Rica - PLAYA MUERTO, DARIEN, PANAMA - Fuerte Amador, Panama - Panama Canal Transit - San Blas Islands, Panama - Colon, Panama - View more ports
Ports
- Seattle, Washington
- San Francisco, California
- Los Angeles, California
- Cabo San Lucas, Mexico
- Puntarenas, Costa Rica
- Panama Canal Transit
- Cartagena, Colombia
- Oranjestad, Aruba
- Miami, Florida
Ports
Seattle, Washington - San Francisco, California - Los Angeles, California - Cabo San Lucas, Mexico - Puntarenas, Costa Rica - Panama Canal Transit - Cartagena, Colombia - Oranjestad, Aruba - Miami, Florida - View more ports
Ports
- Seattle, Washington
- San Francisco, California
- Los Angeles, California
- Cabo San Lucas, Mexico
- Puntarenas, Costa Rica
- Panama Canal Transit
- Cartagena, Colombia
- Oranjestad, Aruba
- Miami, Florida
- San Juan, Puerto Rico
- St. John's, Antigua
- Castries, St. Lucia
- Bridgetown, Barbados
- Philipsburg, St. Maarten
- Tortola, British Virgin Islands
Ports
Seattle, Washington - San Francisco, California - Los Angeles, California - Cabo San Lucas, Mexico - Puntarenas, Costa Rica - Panama Canal Transit - Cartagena, Colombia - Oranjestad, Aruba - Miami, Florida - San Juan, Puerto Rico - St. John's, Antigua - Castries, St. Lucia - Bridgetown, Barbados - Philipsburg, St. Maarten - Tortola, British Virgin Islands - View more ports
Ports
- San Diego, California
- Cabo San Lucas, Mexico
- Mazatlan, Mexico
- Puerto Quetzal, Guatemala
- Puntarenas, Costa Rica
- Panama Canal Transit
- Colon, Panama
- Cartagena, Colombia
- George Town, Grand Cayman
- Ft. Lauderdale (Port Everglades), Florida
Ports
San Diego, California - Cabo San Lucas, Mexico - Mazatlan, Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Colon, Panama - Cartagena, Colombia - George Town, Grand Cayman - Ft. Lauderdale (Port Everglades), Florida - View more ports
Top positive review
Top critical review
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
See Offers |
$2208* |
$2961* |
N/A |
N/A |
|
|
|
$2208* |
$2961* |
N/A |
N/A |
||
|
|
$2208* |
$2961* |
N/A |
N/A |
||
|
|
See Offers |
$2208* |
$2961* |
N/A |
N/A |
Ports
- Ft. Lauderdale (Port Everglades), Florida
- Cozumel, Mexico
- Colon, Panama
- Panama Canal Transit
- Manta, Ecuador
- Callao (Lima), Peru
- Iquique, Chile
- Valparaiso (Santiago), Chile
Ports
Ft. Lauderdale (Port Everglades), Florida - Cozumel, Mexico - Colon, Panama - Panama Canal Transit - Manta, Ecuador - Callao (Lima), Peru - Iquique, Chile - Valparaiso (Santiago), Chile - View more ports
17 Night Panama & Scenic South America (Ft. Lauderdale To Santiago)
2025 sail dates:
Ports
- Seattle, Washington
- Cabo San Lucas, Mexico
- Puntarenas, Costa Rica
- Panama Canal Transit
- Cartagena, Colombia
- New Orleans, Louisiana
Ports
Seattle, Washington - Cabo San Lucas, Mexico - Puntarenas, Costa Rica - Panama Canal Transit - Cartagena, Colombia - New Orleans, Louisiana - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
N/A |
N/A |
N/A |
$3964* |
||
|
|
$1098* |
$1418* |
$1688* |
$3949* |
||
|
|
N/A |
N/A |
N/A |
$3964* |
||
|
|
See Offers |
N/A |
N/A |
N/A |
$3964* |
|
|
|
See Offers |
N/A |
N/A |
N/A |
$3964* |
Ports
- Ft. Lauderdale (Port Everglades), Florida
- Cozumel, Mexico
- Colon, Panama
- Panama Canal Transit
- Manta, Ecuador
- Callao (Lima), Peru
- Iquique, Chile
- Valparaiso (Santiago), Chile
Ports
Ft. Lauderdale (Port Everglades), Florida - Cozumel, Mexico - Colon, Panama - Panama Canal Transit - Manta, Ecuador - Callao (Lima), Peru - Iquique, Chile - Valparaiso (Santiago), Chile - View more ports
17 Night Panama & Scenic South America (Ft. Lauderdale To Santiago)
2025 sail dates:
2026 sail dates: Nov 06
Ports
- San Diego, California
- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puerto Chiapas (Tapachula), Mexico
- Puerto Quetzal, Guatemala
- Puntarenas, Costa Rica
- Panama Canal Transit
- Oranjestad, Aruba
- Half Moon Cay, Bahamas (Private Island)
- Ft. Lauderdale (Port Everglades), Florida
Ports
San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Half Moon Cay, Bahamas (Private Island) - Ft. Lauderdale (Port Everglades), Florida - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
$2094* |
$2894* |
$3194* |
$4739* |
||
|
|
See Offers |
$2229* |
$3029* |
$3329* |
$4874* |
|
|
|
$2214* |
$3014* |
$3314* |
$4859* |
||
|
|
$2229* |
$3029* |
$3329* |
$4874* |
||
|
|
See Offers |
$2229* |
$3029* |
$3329* |
$4874* |
|
|
|
See Offers |
$2229* |
$3029* |
$3329* |
$4874* |
|
|
|
See Offers |
$2229* |
$3029* |
$3329* |
$4874* |
|
|
See Offers |
$2229* |
$3029* |
$3329* |
$4874* |
|
|
|
See Offers |
$2229* |
$3029* |
$3329* |
$4874* |
Ports
- San Diego, California
- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puerto Chiapas (Tapachula), Mexico
- Puerto Quetzal, Guatemala
- Acajutla
- Puntarenas, Costa Rica
- Panama Canal Transit
- Oranjestad, Aruba
- Ft. Lauderdale (Port Everglades), Florida
- Philipsburg, St. Maarten
- St. John's, Antigua
- Castries, St. Lucia
- Roseau, Dominica
- Basseterre, St. Kitts
- Charlotte Amalie, St. Thomas
- Half Moon Cay, Bahamas (Private Island)
Ports
San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Acajutla - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - Philipsburg, St. Maarten - St. John's, Antigua - Castries, St. Lucia - Roseau, Dominica - Basseterre, St. Kitts - Charlotte Amalie, St. Thomas - Half Moon Cay, Bahamas (Private Island) - View more ports
| Partners | Bonus Offers | Inside | Oceanview | Balcony | Suite | |
|---|---|---|---|---|---|---|
|
|
$3329* |
$4559* |
$5089* |
$7409* |
||
|
|
See Offers |
$3574* |
$4804* |
$5334* |
$7654* |
|
|
|
$3559* |
$4789* |
$5319* |
$7639* |
||
|
|
$3574* |
$4804* |
$5334* |
$7654* |
||
|
|
See Offers |
$3574* |
$4804* |
$5334* |
$7654* |
|
|
|
See Offers |
$3574* |
$4804* |
$5334* |
$7654* |
|
|
|
See Offers |
$3574* |
$4804* |
$5334* |
$7654* |
|
|
|
See Offers |
$3574* |
$4804* |
$5334* |
$7654* |
|
|
|
See Offers |
$3574* |
$4804* |
$5334* |
$7654* |
Ports
- San Pedro (Los Angeles), California
- Ensenada, Mexico
- Cabo San Lucas, Mexico
- Acapulco, Mexico
- Puerto Quetzal, Guatemala
- Puerto Corinto, Nicaragua
- Puntarenas, Costa Rica
- Panama Canal Transit
- Colon, Panama
Ports
San Pedro (Los Angeles), California - Ensenada, Mexico - Cabo San Lucas, Mexico - Acapulco, Mexico - Puerto Quetzal, Guatemala - Puerto Corinto, Nicaragua - Puntarenas, Costa Rica - Panama Canal Transit - Colon, Panama - View more ports
All prices are per person based on double occupancy and do not include port/government fees and gratuities.
More popular cruise lines sailing to Panama Canal, Central America
More popular departure ports with sailings to Panama Canal, Central America
- Ft. Lauderdale (Port Everglades), Florida Cruises to Panama Canal, Central America
- Miami, Florida Cruises to Panama Canal, Central America
- Tampa, Florida Cruises to Panama Canal, Central America
- Seattle, Washington Cruises to Panama Canal, Central America
- New York, New York Cruises to Panama Canal, Central America