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Panama Canal, Central America cruises 344 Panama Canal, Central America Cruises Found

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344 cruises found

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Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Quetzal, Guatemala
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • Los Angeles, California
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - Los Angeles, California - View more ports

Silver Moon XL

4.4
(10 Reviews)

2025 sail dates:

$9400*
$522/night*
Suite
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$9400* luxurycruiseconnections.com $10900* luxuryonly.com $10900* dreamvacations.com $10900* gotosea.com
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$9400*

 

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$10900*

 

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$10900*

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$10900*

Ports

  • Panama City, Panama
  • Panama Canal Transit
  • Cartagena, Colombia
  • Santa Marta, Colombia
  • Oranjestad, Aruba
  • Willemstad, Curacao
  • Kralendijk, Bonaire
  • Port Antonio, Jamaica
  • Miami, Florida
View more ports

Ports

Panama City, Panama - Panama Canal Transit - Cartagena, Colombia - Santa Marta, Colombia - Oranjestad, Aruba - Willemstad, Curacao - Kralendijk, Bonaire - Port Antonio, Jamaica - Miami, Florida - View more ports

Sirena S

4.0
(86 Reviews)

2025 sail dates:

$3199*
$320/night*
Inside
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$3199* luxurycruiseconnections.com $3199* luxuryonly.com $3199* directlinecruises.com $3199* dreamvacations.com $3199* gotosea.com $3199* americandiscountcruises.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

$3199*

$3549*

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$3199*

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Ports

  • Los Angeles, California
  • Cabo San Lucas, Mexico
  • CORINTO (LEON), NICARAGUA
  • Puerto Caldera, Costa Rica
  • Panama Canal Transit
  • Colon, Panama
  • Cartagena, Colombia
  • Cozumel, Mexico
  • Ft. Lauderdale (Port Everglades), Florida
View more ports

Ports

Los Angeles, California - Cabo San Lucas, Mexico - CORINTO (LEON), NICARAGUA - Puerto Caldera, Costa Rica - Panama Canal Transit - Colon, Panama - Cartagena, Colombia - Cozumel, Mexico - Ft. Lauderdale (Port Everglades), Florida - View more ports

Viking Neptune M

4.1
(11 Reviews)

2025 sail dates:

$5099*
$300/night*
Balcony
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$5099* directlinecruises.com $5099* luxurycruiseconnections.com $6099* luxuryonly.com $6099* dreamvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

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$5099*

$10999*

 

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$6099*

$11999*

 

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Ports

  • Valparaiso (Santiago), Chile
  • Coquimbo (La Serena), Chile
  • Iquique, Chile
  • Arica, Chile
  • PARACAS, PERU
  • Callao (Lima), Peru
  • Salaverry (Trujillo), Peru
  • PUERTO LOPEZ, ECUADOR
  • Manta, Ecuador
  • Cross The Equator
  • PANAMA CITY (FUERTE AMADOR), PANAMA
View more ports

Ports

Valparaiso (Santiago), Chile - Coquimbo (La Serena), Chile - Iquique, Chile - Arica, Chile - PARACAS, PERU - Callao (Lima), Peru - Salaverry (Trujillo), Peru - PUERTO LOPEZ, ECUADOR - Manta, Ecuador - Cross The Equator - PANAMA CITY (FUERTE AMADOR), PANAMA - View more ports

MS Fram S

2025 sail dates:

$5887*
$421/night*
Oceanview
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$5887* dreamvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5887*

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$7437*

Ports

  • Long Beach (Los Angeles), California
  • Puerto Vallarta, Mexico
  • Huatulco, Mexico
  • Puerto Chiapas (Tapachula), Mexico
  • Puerto Quetzal, Guatemala
  • Puntarenas, Costa Rica
  • Panama Canal Transit
  • Cartagena, Colombia
  • Miami, Florida
View more ports

Ports

Long Beach (Los Angeles), California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Cartagena, Colombia - Miami, Florida - View more ports

Seabourn Encore S

4.4
(27 Reviews)

2025 sail dates:

$8146*
$429/night*
Suite
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$8146* seabourn.com $7649* luxuryonly.com $7649* dreamvacations.com $6229* gotosea.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$8146*

 

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$7649*

 

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$7649*

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$6229*

Ports

  • Tampa, Florida
  • George Town, Grand Cayman
  • Cartagena, Colombia
  • Colon, Panama
  • Panama Canal Transit
  • Puerto Quetzal, Guatemala
  • Puerto Vallarta, Mexico
  • Los Angeles, California
View more ports

Ports

Tampa, Florida - George Town, Grand Cayman - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Los Angeles, California - View more ports

Radiance of the Seas L

4.2
(1273 Reviews)

2025 sail dates:

$1607*
$107/night*
Inside
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$1607* cruises.com $1607* directlinecruises.com $1607* cheapcruises.com $1607* cruisesonly.com $1607* dreamvacations.com $1607* gotosea.com $1637* americandiscountvacations.com $1667* cruisehub.com $1637* americandiscountcruises.com
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Ports

  • San Diego, California
  • Cabo San Lucas, Mexico
  • Puntarenas, Costa Rica
  • PANAMA CITY (FUERTE AMADOR), PANAMA
  • Panama Canal Transit
  • Cartagena, Colombia
  • Ft. Lauderdale (Port Everglades), Florida
View more ports

Ports

San Diego, California - Cabo San Lucas, Mexico - Puntarenas, Costa Rica - PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Cartagena, Colombia - Ft. Lauderdale (Port Everglades), Florida - View more ports

Silver Shadow S

3.8
(32 Reviews)

2025 sail dates:

$9500*
$528/night*
Suite
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$9500* luxurycruiseconnections.com $10600* luxuryonly.com $10600* dreamvacations.com $8100* gotosea.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$9500*

 

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$10600*

 

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$10600*

See Offers

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$8100*

Ports

  • San Diego, California
  • Cabo San Lucas, Mexico
  • Puntarenas, Costa Rica
  • PANAMA CITY (FUERTE AMADOR), PANAMA
View more ports

Ports

San Diego, California - Cabo San Lucas, Mexico - Puntarenas, Costa Rica - PANAMA CITY (FUERTE AMADOR), PANAMA - View more ports

Silver Shadow S

3.8
(32 Reviews)

2025 sail dates:

$6500*
$591/night*
Suite
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$6500* luxurycruiseconnections.com $6500* luxuryonly.com $6500* dreamvacations.com $6500* gotosea.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$6500*

 

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$6500*

 

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$6500*

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$6500*

Ports

  • PANAMA CITY (FUERTE AMADOR), PANAMA
  • Panama Canal Transit
  • Cartagena, Colombia
  • Ft. Lauderdale (Port Everglades), Florida
View more ports

Ports

PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Cartagena, Colombia - Ft. Lauderdale (Port Everglades), Florida - View more ports

Silver Shadow S

3.8
(32 Reviews)

2025 sail dates:

$5800*
$829/night*
Suite
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$5800* luxurycruiseconnections.com $5800* luxuryonly.com $5800* dreamvacations.com $5800* gotosea.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5800*

 

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$5800*

 

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$5800*

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$5800*

Ports

  • San Francisco, California
  • San Pedro (Los Angeles), California
  • Ensenada, Mexico
  • Cabo San Lucas, Mexico
  • Acapulco, Mexico
  • Puerto Quetzal, Guatemala
  • Puerto Corinto, Nicaragua
  • Puntarenas, Costa Rica
  • Panama Canal Transit
  • Cartagena, Colombia
  • George Town, Grand Cayman
  • Miami, Florida
View more ports

Ports

San Francisco, California - San Pedro (Los Angeles), California - Ensenada, Mexico - Cabo San Lucas, Mexico - Acapulco, Mexico - Puerto Quetzal, Guatemala - Puerto Corinto, Nicaragua - Puntarenas, Costa Rica - Panama Canal Transit - Cartagena, Colombia - George Town, Grand Cayman - Miami, Florida - View more ports

Seven Seas Mariner S

3.9
(100 Reviews)

2025 sail dates:

$13130*
$729/night*
Suite
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$13130* luxurycruiseconnections.com $9730* avoyatravel.com $13399* luxuryonly.com $13399* dreamvacations.com $9730* gotosea.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$13130*

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$9730*

 

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$13399*

 

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$13399*

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$9730*

141 - 150 of 344

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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