Puerto Quetzal, Guatemala Cruises: Top Itineraries and Pricing

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
PANAMA CITY (FUERTE AMADOR), PANAMA
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Manzanillo, Mexico
San Francisco, California

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - PANAMA CITY (FUERTE AMADOR), PANAMA - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Manzanillo, Mexico - San Francisco, California - View more ports

16 Night Panama Canal - Ocean To Ocean Holiday (Ft. Lauderdale To San Francisco)

Island Princess M

4.0

(908 Reviews)

2025 sail dates: Nov 21

$1369*

$86/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1369*	$1809*	$2359*	$6259*
	$1569*	$1713*	$2517*	$2830*
	$1569*	$1713*	$2517*	$2830*
See Offers	$1369*	$1513*	$2317*	$2630*
See Offers	$1369*	$1513*	$2317*	$2630*
See Offers	$1569*	$1713*	$2517*	$2830*
See Offers	$1369*	$1513*	$2317*	$2630*

Ports

San Francisco, California
Mazatlan, Mexico
Puerto Vallarta, Mexico
Puerto Quetzal, Guatemala
Puntarenas, Costa Rica
PANAMA CITY (FUERTE AMADOR), PANAMA
Panama Canal Transit
Cartagena, Colombia
Ft. Lauderdale (Port Everglades), Florida

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Ports

San Francisco, California - Mazatlan, Mexico - Puerto Vallarta, Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Cartagena, Colombia - Ft. Lauderdale (Port Everglades), Florida - View more ports

17 Night Panama Canal - Ocean To Ocean (San Francisco To Ft. Lauderdale)

Ruby Princess L

4.1

(1571 Reviews)

2026 sail dates: Aug 31

$1449*

$85/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1449*	$1649*	$2549*	$5049*
	$1449*	$1569*	$2549*	$3449*
	$1449*	$1569*	$2549*	$3449*
See Offers	$1449*	$1569*	$2549*	$3449*
See Offers	$1449*	$1569*	$2549*	$3449*
See Offers	$1449*	$1569*	$2549*	$3449*
See Offers	$1449*	$1569*	$2549*	$3449*

Ports

Seattle, Washington
Vancouver (Canada Place), British Columbia
Santa Barbara, California
San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Acajutla
Puntarenas, Costa Rica
Panama Canal Transit
Oranjestad, Aruba
Ft. Lauderdale (Port Everglades), Florida
Grand Turk Island
San Juan, Puerto Rico
Charlotte Amalie, St. Thomas
Half Moon Cay, Bahamas (Private Island)

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Ports

Seattle, Washington - Vancouver (Canada Place), British Columbia - Santa Barbara, California - San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Acajutla - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - San Juan, Puerto Rico - Charlotte Amalie, St. Thomas - Half Moon Cay, Bahamas (Private Island) - View more ports

29 Night Panama Canal & Eastern Caribbean (Seattle To Ft. Lauderdale)

Eurodam L

4.1

(1100 Reviews)

2025 sail dates: Oct 04

$3314*

$114/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3314*	$3934*	$5124*	$9264*
	$3589*	$4209*	$5399*	$9539*
	$3589*	$4209*	$5399*	$9539*
	$3589*	$4209*	$5374*	$9004*
See Offers	$3589*	$4209*	$5399*	$9029*
See Offers	$3589*	$4209*	$5399*	$9539*
See Offers	$3589*	$4209*	$5399*	$9029*
See Offers	$3589*	$4209*	$5399*	$9029*

Ports

Miami, Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Huatulco, Mexico
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

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Ports

Miami, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

15 Night Panama Canal (Miami To San Diego)

Zuiderdam M

4.0

(748 Reviews)

2026 sail dates: Jan 31

$2304*

$154/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2304*	$2604*	$3304*	$4804*
	$1894*	$2194*	$2894*	$4394*
	$1894*	$2194*	$2894*	$4394*
	$2399*	$2699*	$3374*	$4874*
See Offers	$2399*	$2699*	$3399*	$4899*
See Offers	$1894*	$2194*	$2894*	$4394*
See Offers	$2399*	$2699*	$3399*	$4899*
See Offers	$2399*	$2699*	$3399*	$4899*

Ports

San Pedro (Los Angeles), California
Cabo San Lucas, Mexico
Acapulco, Mexico
Puerto Quetzal, Guatemala
Puerto Caldera, Costa Rica
Panama City, Panama
Panama Canal Transit
Cartagena, Colombia
Falmouth, Jamaica
Miami, Florida
New York, New York

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Ports

San Pedro (Los Angeles), California - Cabo San Lucas, Mexico - Acapulco, Mexico - Puerto Quetzal, Guatemala - Puerto Caldera, Costa Rica - Panama City, Panama - Panama Canal Transit - Cartagena, Colombia - Falmouth, Jamaica - Miami, Florida - New York, New York - View more ports

19 Night Panama Canal: Mexico & Jamaica (Los Angeles To New York)

Norwegian Bliss XL

4.1

(1347 Reviews)

2026 sail dates: Oct 13

$2346*

$123/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$2346*	$3096*	$3796*	$10846*
See Offers	$2346*	$3096*	$3796*	$4396*
	$2346*	$3096*	$3796*	$4396*
See Offers	$2346*	$3096*	$3796*	$4396*
See Offers	$2346*	$3096*	$3796*	$4396*
	$2346*	$3096*	$3796*	$4396*
See Offers	$2346*	$3096*	$3796*	$4396*
See Offers	$2346*	$3096*	$3796*	$4396*
	$2346*	$3096*	$3796*	$4396*

Ports

Miami, Florida
Half Moon Cay, Bahamas (Private Island)
Grand Turk Island
Amber Cove (Puerto Plata), Dominican Republic
Key West, Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Acajutla
Puerto Quetzal, Guatemala
Huatulco, Mexico
Puerto Vallarta, Mexico
Cabo San Lucas, Mexico
San Diego, California

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Ports

Miami, Florida - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Amber Cove (Puerto Plata), Dominican Republic - Key West, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

22 Night Eastern Caribbean & Panama Canal (Miami To San Diego)

Zuiderdam M

4.0

(748 Reviews)

2026 sail dates: Jan 24

$3049*

$139/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3049*	$3479*	$4379*	$6559*
	$3239*	$3669*	$4569*	$6749*
	$3239*	$3669*	$4569*	$6749*
	$3239*	$3669*	$4544*	$6724*
See Offers	$3239*	$3669*	$4569*	$6749*
See Offers	$3239*	$3669*	$4569*	$6749*
See Offers	$3239*	$3669*	$4569*	$6749*
See Offers	$3239*	$3669*	$4569*	$6749*

Ports

San Diego, California
Cabo San Lucas, Mexico
Pichilingue (La Paz), Mexico
Loreto, Mexico
Guaymas, Mexico
Topolobampo, Mexico
Mazatlan, Mexico
Puerto Vallarta, Mexico
Ensenada, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Fuerte Amador, Panama
Panama Canal Transit
Cartagena, Colombia
Half Moon Cay, Bahamas (Private Island)
Miami, Florida

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Ports

San Diego, California - Cabo San Lucas, Mexico - Pichilingue (La Paz), Mexico - Loreto, Mexico - Guaymas, Mexico - Topolobampo, Mexico - Mazatlan, Mexico - Puerto Vallarta, Mexico - Ensenada, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Fuerte Amador, Panama - Panama Canal Transit - Cartagena, Colombia - Half Moon Cay, Bahamas (Private Island) - Miami, Florida - View more ports

27 Night Historic Sea Of Cortez & Panama Canal (San Diego To Miami)

Zuiderdam M

4.0

(748 Reviews)

2026 sail dates: Feb 15

$3899*

$144/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$3899*	$4369*	$5589*	$8449*
See Offers	$4054*	$4524*	$5744*	$8604*
	$4054*	$4524*	$5744*	$8604*
	$4054*	$4524*	$5719*	$8579*
See Offers	$4054*	$4524*	$5744*	$8604*
See Offers	$4054*	$4524*	$5744*	$8604*
See Offers	$4054*	$4524*	$5744*	$8604*
See Offers	$4054*	$4524*	$5744*	$8604*

Ports

Ft. Lauderdale (Port Everglades), Florida
Cartagena, Colombia
Panama Canal Transit
Puntarenas, Costa Rica
Puerto Quetzal, Guatemala
Puerto Vallarta, Mexico
San Pedro (Los Angeles), California
Honolulu, Oahu

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Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - San Pedro (Los Angeles), California - Honolulu, Oahu - View more ports

21 Night World Voyage Segment - Panama Canal Connoisseur (Ft. Lauderdale To Honolulu)

Island Princess M

4.0

(908 Reviews)

2025 sail dates: Jan 05

$1858*

$88/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1858*	$2298*	$3348*	$7689*
	$1355*	$1618*	$2845*	$3425*
	$1355*	$1618*	$2845*	$3425*
See Offers	$1858*	$2121*	$3348*	$3929*
See Offers	$1858*	$2121*	$3348*	$3929*
See Offers	$1355*	$1618*	$2845*	$3425*
See Offers	$1858*	$2121*	$3348*	$3929*

Ports

Tampa, Florida
Cartagena, Colombia
Colon, Panama
Panama Canal Transit
Puerto Caldera, Costa Rica
San Juan Del Sur, Nicaragua
Puerto Quetzal, Guatemala
Acapulco, Mexico
Cabo San Lucas, Mexico
San Pedro (Los Angeles), California
San Francisco, California
Astoria, Oregon
KETCHIKAN (WARD COVE), ALASKA
Juneau, Alaska
Skagway, Alaska
Cruise Hubbard Glacier
Whittier (Anchorage), Alaska

View more ports

Ports

Tampa, Florida - Cartagena, Colombia - Colon, Panama - Panama Canal Transit - Puerto Caldera, Costa Rica - San Juan Del Sur, Nicaragua - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - San Pedro (Los Angeles), California - San Francisco, California - Astoria, Oregon - KETCHIKAN (WARD COVE), ALASKA - Juneau, Alaska - Skagway, Alaska - Cruise Hubbard Glacier - Whittier (Anchorage), Alaska - View more ports

25 Night Panama Canal: Alaska & Mexico (Tampa To Whittier)

Norwegian Jade L

3.9

(1405 Reviews)

2025 sail dates: Apr 03

$2505*

$100/night*

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Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$2505*	$2605*	$4405*	$12175*
See Offers	$2354*	$2605*	$4405*	$4705*
	$2354*	$2605*	$4405*	$4705*
See Offers	$2505*	$2605*	$4405*	$4705*
See Offers	$2354*	$2605*	$4405*	$4705*
	$2354*	$2605*	$4405*	$4705*
See Offers	$2354*	$2605*	$4405*	$4705*
See Offers	$2505*	$2605*	$4405*	$4705*
	$2354*	$2605*	$4405*	$4705*

Ports

San Diego, California
Puerto Vallarta, Mexico
Huatulco, Mexico
Puerto Chiapas (Tapachula), Mexico
Puerto Quetzal, Guatemala
Fuerte Amador, Panama
Panama Canal Transit
Cartagena, Colombia
Half Moon Cay, Bahamas (Private Island)
Miami, Florida

View more ports

Ports

San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Fuerte Amador, Panama - Panama Canal Transit - Cartagena, Colombia - Half Moon Cay, Bahamas (Private Island) - Miami, Florida - View more ports

15 Night Panama Canal (San Diego To Miami)

Zuiderdam M

4.0

(748 Reviews)

2026 sail dates: Feb 27

$2384*

$159/night*

Inside

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Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2384*	$2684*	$3384*	$4874*
	$2499*	$2799*	$3499*	$4989*
	$2499*	$2799*	$3499*	$4989*
	$2499*	$2799*	$3474*	$4964*
See Offers	$2499*	$2799*	$3499*	$4989*
See Offers	$2499*	$2799*	$3499*	$4989*
See Offers	$2499*	$2799*	$3499*	$4989*
See Offers	$2499*	$2799*	$3499*	$4989*

Puerto Quetzal, Guatemala cruises 139 Puerto Quetzal, Guatemala cruises

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