1. Home
  2. Find a cruise
  3. Panama City, Panama cruises

Panama City, Panama cruises 40 Panama City, Panama cruises

Your search Clear selections

Any Destination
All Sail Months
Any Length
Panama City, Panama
Any Cruise Line
Any Ship

Close

40 cruises found

Filters Save search

Sort by

Filter by

Save search

Ports

  • Miami, Florida
  • Puerto Plata, Dominican Republic
  • San Juan, Puerto Rico
  • Philipsburg, St. Maarten
  • Charlotte Amalie, St. Thomas
  • Tortola, British Virgin Islands
  • Castries, St. Lucia
  • Oranjestad, Aruba
  • Cartagena, Colombia
  • Colon, Panama
  • Puerto Limon, Costa Rica
  • Panama Canal Transit
  • Panama City, Panama
View more ports

Ports

Miami, Florida - Puerto Plata, Dominican Republic - San Juan, Puerto Rico - Philipsburg, St. Maarten - Charlotte Amalie, St. Thomas - Tortola, British Virgin Islands - Castries, St. Lucia - Oranjestad, Aruba - Cartagena, Colombia - Colon, Panama - Puerto Limon, Costa Rica - Panama Canal Transit - Panama City, Panama - View more ports

Norwegian Jade L

3.9
(1410 Reviews)

2025 sail dates:

$975*
$65/night*
Inside
View Deal
$975* ncl.com $975* cruises.com $975* cheapcruises.com $975* directlinecruises.com $975* cruisesonly.com $975* americandiscountcruises.com $975* gotosea.com $974* cruisehub.com $975* americandiscountvacations.com $975* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 1410 Norwegian Jade reviews

Ports

  • Miami, Florida
  • Cozumel, Mexico
  • Costa Maya (Mahahual), Mexico
  • Harvest Caye, Belize
  • Santo Tomas De Castilla, Guatemala
  • Coxen Hole, Roatan, Bay Islands, Honduras
  • Puerto Limon, Costa Rica
  • Panama City, Panama
  • Panama Canal Transit
View more ports

Ports

Miami, Florida - Cozumel, Mexico - Costa Maya (Mahahual), Mexico - Harvest Caye, Belize - Santo Tomas De Castilla, Guatemala - Coxen Hole, Roatan, Bay Islands, Honduras - Puerto Limon, Costa Rica - Panama City, Panama - Panama Canal Transit - View more ports

Sirena S

4.0
(86 Reviews)

2025 sail dates:

$3399*
$340/night*
Inside
View Deal
$3399* luxurycruiseconnections.com $3399* avoyatravel.com $3399* luxuryonly.com $2890* directlinecruises.com $2890* americandiscountcruises.com $2890* gotosea.com $3399* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 86 Sirena reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

$3399*

$3749*

N/A

N/A

See Offers

$3399*

$3749*

N/A

N/A

 

$3399*

$3749*

N/A

N/A

See Offers

$2890*

$3187*

N/A

N/A

See Offers

$2890*

$3187*

N/A

N/A

See Offers

$2890*

$3187*

N/A

N/A

 

$3399*

$3749*

N/A

N/A

Ports

  • Miami, Florida
  • Cozumel, Mexico
  • Costa Maya (Mahahual), Mexico
  • Harvest Caye, Belize
  • Santo Tomas De Castilla, Guatemala
  • Coxen Hole, Roatan, Bay Islands, Honduras
  • Puerto Limon, Costa Rica
  • Panama Canal Transit
  • Panama City, Panama
  • Cartagena, Colombia
  • Santa Marta, Colombia
  • Oranjestad, Aruba
  • Willemstad, Curacao
  • Kralendijk, Bonaire
  • Port Antonio, Jamaica
  • Nassau, Bahamas
View more ports

Ports

Miami, Florida - Cozumel, Mexico - Costa Maya (Mahahual), Mexico - Harvest Caye, Belize - Santo Tomas De Castilla, Guatemala - Coxen Hole, Roatan, Bay Islands, Honduras - Puerto Limon, Costa Rica - Panama Canal Transit - Panama City, Panama - Cartagena, Colombia - Santa Marta, Colombia - Oranjestad, Aruba - Willemstad, Curacao - Kralendijk, Bonaire - Port Antonio, Jamaica - Nassau, Bahamas - View more ports

Sirena S

4.0
(86 Reviews)

2025 sail dates:

$6299*
$300/night*
Inside
View Deal
$6299* luxurycruiseconnections.com $6299* avoyatravel.com $6299* luxuryonly.com $6299* directlinecruises.com $6299* americandiscountcruises.com $6299* gotosea.com $6299* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 86 Sirena reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

$6299*

N/A

N/A

N/A

See Offers

$6299*

N/A

N/A

N/A

 

$6299*

N/A

N/A

N/A

See Offers

$6299*

N/A

N/A

N/A

See Offers

$6299*

N/A

N/A

N/A

See Offers

$6299*

N/A

N/A

N/A

 

$6299*

N/A

N/A

N/A

Ports

  • Panama City, Panama
  • Panama Canal Transit
  • Cartagena, Colombia
  • Santa Marta, Colombia
  • Oranjestad, Aruba
  • Willemstad, Curacao
  • Kralendijk, Bonaire
  • Port Antonio, Jamaica
  • Nassau, Bahamas
  • Miami, Florida
View more ports

Ports

Panama City, Panama - Panama Canal Transit - Cartagena, Colombia - Santa Marta, Colombia - Oranjestad, Aruba - Willemstad, Curacao - Kralendijk, Bonaire - Port Antonio, Jamaica - Nassau, Bahamas - Miami, Florida - View more ports

Sirena S

4.0
(86 Reviews)

2025 sail dates:

$3330*
$303/night*
Inside
View Deal
$3330* luxurycruiseconnections.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 86 Sirena reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

$3330*

N/A

N/A

N/A

Ports

  • Callao (Lima), Peru
  • Salaverry (Trujillo), Peru
  • Manta, Ecuador
  • Panama City, Panama
  • Puntarenas, Costa Rica
  • San Juan Del Sur, Nicaragua
  • Acajutla
  • Puerto Quetzal, Guatemala
  • Huatulco, Mexico
  • Acapulco, Mexico
  • Manzanillo, Mexico
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • San Diego, California
View more ports

Ports

Callao (Lima), Peru - Salaverry (Trujillo), Peru - Manta, Ecuador - Panama City, Panama - Puntarenas, Costa Rica - San Juan Del Sur, Nicaragua - Acajutla - Puerto Quetzal, Guatemala - Huatulco, Mexico - Acapulco, Mexico - Manzanillo, Mexico - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

Norwegian Jade L

3.9
(1410 Reviews)

2026 sail dates:

$2620*
$154/night*
Inside
View Deal
$2620* ncl.com $2081* cruises.com $2081* cheapcruises.com $2620* directlinecruises.com $2081* cruisesonly.com $2081* americandiscountcruises.com $2620* gotosea.com $2620* cruisehub.com $2081* americandiscountvacations.com $2081* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 1410 Norwegian Jade reviews

Ports

  • Miami, Florida
  • George Town, Grand Cayman
  • Ocho Rios, Jamaica
  • Kralendijk, Bonaire
  • Willemstad, Curacao
  • Oranjestad, Aruba
  • Cartagena, Colombia
  • Puerto Limon, Costa Rica
  • Panama Canal Transit
  • Panama City, Panama
  • Puntarenas, Costa Rica
  • Puerto Corinto, Nicaragua
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • Ensenada, Mexico
  • Los Angeles, California
View more ports

Ports

Miami, Florida - George Town, Grand Cayman - Ocho Rios, Jamaica - Kralendijk, Bonaire - Willemstad, Curacao - Oranjestad, Aruba - Cartagena, Colombia - Puerto Limon, Costa Rica - Panama Canal Transit - Panama City, Panama - Puntarenas, Costa Rica - Puerto Corinto, Nicaragua - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - Ensenada, Mexico - Los Angeles, California - View more ports

Seven Seas Grandeur M

4.1
(7 Reviews)

2026 sail dates:

$14599*
$664/night*
Suite
View Deal
$14599* luxurycruiseconnections.com $14599* avoyatravel.com $14599* luxuryonly.com $14599* gotosea.com $14599* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 7 Seven Seas Grandeur reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

N/A

$14599*

See Offers

N/A

N/A

N/A

$14599*

 

N/A

N/A

N/A

$14599*

See Offers

N/A

N/A

N/A

$14599*

 

N/A

N/A

N/A

$14599*

Ports

  • Miami, Florida
  • George Town, Grand Cayman
  • Ocho Rios, Jamaica
  • Kralendijk, Bonaire
  • Willemstad, Curacao
  • Oranjestad, Aruba
  • Cartagena, Colombia
  • Puerto Limon, Costa Rica
  • Panama Canal Transit
  • Panama City, Panama
View more ports

Ports

Miami, Florida - George Town, Grand Cayman - Ocho Rios, Jamaica - Kralendijk, Bonaire - Willemstad, Curacao - Oranjestad, Aruba - Cartagena, Colombia - Puerto Limon, Costa Rica - Panama Canal Transit - Panama City, Panama - View more ports

Seven Seas Grandeur M

4.1
(7 Reviews)

2026 sail dates:

$8499*
$708/night*
Suite
View Deal
$8499* luxurycruiseconnections.com $8499* avoyatravel.com $8499* luxuryonly.com $8499* gotosea.com $8499* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 7 Seven Seas Grandeur reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

N/A

$8499*

See Offers

N/A

N/A

N/A

$8499*

 

N/A

N/A

N/A

$8499*

See Offers

N/A

N/A

N/A

$8499*

 

N/A

N/A

N/A

$8499*

Ports

  • Panama City, Panama
  • Puntarenas, Costa Rica
  • Puerto Corinto, Nicaragua
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • Ensenada, Mexico
  • Los Angeles, California
View more ports

Ports

Panama City, Panama - Puntarenas, Costa Rica - Puerto Corinto, Nicaragua - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - Ensenada, Mexico - Los Angeles, California - View more ports

Seven Seas Grandeur M

4.1
(7 Reviews)

2026 sail dates:

$6799*
$680/night*
Suite
View Deal
$6799* luxurycruiseconnections.com $6799* avoyatravel.com $6799* luxuryonly.com $6799* gotosea.com $6799* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 7 Seven Seas Grandeur reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

N/A

$6799*

See Offers

$18199*

N/A

N/A

$6799*

 

N/A

N/A

N/A

$6799*

See Offers

N/A

N/A

N/A

$6799*

 

N/A

N/A

N/A

$6799*

Ports

  • Miami, Florida
  • Cozumel, Mexico
  • Costa Maya (Mahahual), Mexico
  • Harvest Caye, Belize
  • Santo Tomas De Castilla, Guatemala
  • Coxen Hole, Roatan, Bay Islands, Honduras
  • Puerto Limon, Costa Rica
  • Panama Canal Transit
  • Panama City, Panama
View more ports

Ports

Miami, Florida - Cozumel, Mexico - Costa Maya (Mahahual), Mexico - Harvest Caye, Belize - Santo Tomas De Castilla, Guatemala - Coxen Hole, Roatan, Bay Islands, Honduras - Puerto Limon, Costa Rica - Panama Canal Transit - Panama City, Panama - View more ports

Nautica S

4.1
(98 Reviews)

2026 sail dates:

$2999*
$300/night*
Inside
View Deal
$2999* luxurycruiseconnections.com $2999* avoyatravel.com $2999* luxuryonly.com $2999* directlinecruises.com $2999* americandiscountcruises.com $2999* gotosea.com $2999* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 98 Nautica reviews

Ports

  • Miami, Florida
  • Cozumel, Mexico
  • Costa Maya (Mahahual), Mexico
  • Harvest Caye, Belize
  • Santo Tomas De Castilla, Guatemala
  • Coxen Hole, Roatan, Bay Islands, Honduras
  • Puerto Limon, Costa Rica
  • Panama Canal Transit
  • Panama City, Panama
  • Cartagena, Colombia
  • Kralendijk, Bonaire
  • Willemstad, Curacao
  • Oranjestad, Aruba
  • Port Antonio, Jamaica
View more ports

Ports

Miami, Florida - Cozumel, Mexico - Costa Maya (Mahahual), Mexico - Harvest Caye, Belize - Santo Tomas De Castilla, Guatemala - Coxen Hole, Roatan, Bay Islands, Honduras - Puerto Limon, Costa Rica - Panama Canal Transit - Panama City, Panama - Cartagena, Colombia - Kralendijk, Bonaire - Willemstad, Curacao - Oranjestad, Aruba - Port Antonio, Jamaica - View more ports

Nautica S

4.1
(98 Reviews)

2026 sail dates:

$5699*
$285/night*
Inside
View Deal
$5699* luxurycruiseconnections.com $5699* avoyatravel.com $5699* luxuryonly.com $5699* directlinecruises.com $5699* americandiscountcruises.com $5699* gotosea.com $5699* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 98 Nautica reviews
21 - 30 of 40

All prices are per person based on double occupancy and do not include port/government fees and gratuities.