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Panama Canal, Central America cruises 329 Panama Canal, Central America Cruises Found

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329 cruises found

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Ports

  • Galveston, Texas
  • Montego Bay, Jamaica
  • Oranjestad, Aruba
  • Willemstad, Curacao
  • Cartagena, Colombia
  • Colon, Panama
  • Puerto Limon, Costa Rica
  • Cozumel, Mexico
View more ports

Ports

Galveston, Texas - Montego Bay, Jamaica - Oranjestad, Aruba - Willemstad, Curacao - Cartagena, Colombia - Colon, Panama - Puerto Limon, Costa Rica - Cozumel, Mexico - View more ports

Carnival Dream L

4.1
(4033 Reviews)

2026 sail dates:

$1419*
$101/night*
Inside
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$1419* cheapcruises.com $1419* cruises.com $1419* cruisesonly.com $1419* dreamvacations.com $1419* americandiscountvacations.com $1419* americandiscountcruises.com
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Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Cozumel, Mexico
  • Puerto Limon, Costa Rica
  • Colon, Panama
  • Panama Canal Transit
  • Manta, Ecuador
  • Callao (Lima), Peru
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cozumel, Mexico - Puerto Limon, Costa Rica - Colon, Panama - Panama Canal Transit - Manta, Ecuador - Callao (Lima), Peru - View more ports

Silver Dawn XL

4.5
(8 Reviews)

2026 sail dates:

$10400*
$800/night*
Suite
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$10400* luxurycruiseconnections.com $10400* luxuryonly.com $10400* cruisesonly.com $10400* cruises.com $10400* dreamvacations.com $10400* americandiscountvacations.com $10400* gotosea.com $10400* americandiscountcruises.com
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Ports

  • Miami, Florida
  • Progreso (Merida), Mexico
  • Puerto Limon, Costa Rica
  • Panama Canal Transit
  • PANAMA CITY (FUERTE AMADOR), PANAMA
  • Manta, Ecuador
  • Guayaquil, Equador
  • Salaverry (Trujillo), Peru
  • Callao (Lima), Peru
View more ports

Ports

Miami, Florida - Progreso (Merida), Mexico - Puerto Limon, Costa Rica - Panama Canal Transit - PANAMA CITY (FUERTE AMADOR), PANAMA - Manta, Ecuador - Guayaquil, Equador - Salaverry (Trujillo), Peru - Callao (Lima), Peru - View more ports

Azamara Onward S

4.3
(31 Reviews)

2026 sail dates:

$3968*
$265/night*
Inside
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$3968* luxurycruiseconnections.com $3967* luxuryonly.com $3967* cruisesonly.com $3967* cruises.com $3967* dreamvacations.com $3968* americandiscountvacations.com $3968* gotosea.com $3968* americandiscountcruises.com
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Ports

  • Callao (Lima), Peru
  • Salaverry (Trujillo), Peru
  • MACHALA, ECUADOR
  • Guayaquil, Equador
  • Manta, Ecuador
  • Panama Canal Transit
  • Colon, Panama
View more ports

Ports

Callao (Lima), Peru - Salaverry (Trujillo), Peru - MACHALA, ECUADOR - Guayaquil, Equador - Manta, Ecuador - Panama Canal Transit - Colon, Panama - View more ports

Star Pride XL

4.4
(36 Reviews)

2026 sail dates: Jan 29

$5036*
$458/night*
Suite
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$5036* luxurycruiseconnections.com $5036* luxuryonly.com $5036* cruisesonly.com $5036* cruises.com $5036* dreamvacations.com
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Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Willemstad, Curacao
  • Kralendijk, Bonaire
  • Oranjestad, Aruba
  • Half Moon Cay, Bahamas (Private Island)
  • Colon, Panama
  • Panama Canal (Cruise Into Canal)
  • Puerto Limon, Costa Rica
  • Falmouth, Jamaica
  • George Town, Grand Cayman
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Willemstad, Curacao - Kralendijk, Bonaire - Oranjestad, Aruba - Half Moon Cay, Bahamas (Private Island) - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - Falmouth, Jamaica - George Town, Grand Cayman - View more ports

Rotterdam L

4.4
(239 Reviews)

2026 sail dates:

$2779*
$132/night*
Inside
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$2779* hollandamerica.com $2986* cruisesonly.com $2986* cruises.com $2986* cheapcruises.com $2986* dreamvacations.com $3039* americandiscountvacations.com $3039* gotosea.com $3039* americandiscountcruises.com
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Ports

  • Miami, Florida
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Corinto, Nicaragua
  • Puerto Quetzal, Guatemala
  • Acapulco, Mexico
  • Cabo San Lucas, Mexico
  • Hilo, Hawaii
  • Kahului, Maui
  • Honolulu, Oahu
View more ports

Ports

Miami, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Corinto, Nicaragua - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - Hilo, Hawaii - Kahului, Maui - Honolulu, Oahu - View more ports

Seven Seas Mariner S

3.9
(97 Reviews)

2026 sail dates:

$16499*
$786/night*
Suite
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$16499* luxurycruiseconnections.com $16349* luxuryonly.com $16349* cruisesonly.com $16349* cruises.com $16349* dreamvacations.com $16499* americandiscountvacations.com $16499* gotosea.com $16499* americandiscountcruises.com
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Ports

  • Southampton (London), England
  • New York, New York
  • Willemstad, Curacao
  • Panama Canal Transit
  • Manzanillo, Mexico
  • San Pedro (Los Angeles), California
View more ports

Ports

Southampton (London), England - New York, New York - Willemstad, Curacao - Panama Canal Transit - Manzanillo, Mexico - San Pedro (Los Angeles), California - View more ports

Queen Mary 2 L

4.2
(395 Reviews)

2026 sail dates:

$5069*
$220/night*
Inside
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$5069* cunard.com $5269* luxurycruiseconnections.com $5269* luxuryonly.com $5269* cruisesonly.com $5269* cruises.com $5269* dreamvacations.com $5269* americandiscountvacations.com $5269* gotosea.com $5269* americandiscountcruises.com
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Ports

  • Southampton (London), England
  • New York, New York
  • Willemstad, Curacao
  • Panama Canal Transit
  • Manzanillo, Mexico
  • San Pedro (Los Angeles), California
  • San Francisco, California
View more ports

Ports

Southampton (London), England - New York, New York - Willemstad, Curacao - Panama Canal Transit - Manzanillo, Mexico - San Pedro (Los Angeles), California - San Francisco, California - View more ports

Queen Mary 2 L

4.2
(395 Reviews)

2026 sail dates:

$5569*
$214/night*
Inside
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$5569* cunard.com $5769* luxurycruiseconnections.com $5769* luxuryonly.com $5769* cruisesonly.com $5769* cruises.com $5769* dreamvacations.com $5769* americandiscountvacations.com $5769* gotosea.com $5769* americandiscountcruises.com
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Ports

  • Miami, Florida
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Corinto, Nicaragua
  • Puerto Quetzal, Guatemala
  • Acapulco, Mexico
  • Cabo San Lucas, Mexico
  • Hilo, Hawaii
  • Kahului, Maui
  • Honolulu, Oahu
  • Nawiliwili, Kauai
  • Lahaina, Maui
  • Cross International Dateline
  • Fanning Island, Kiribati
  • Rangiroa, French Polynesia
  • Raiatea, French Polynesia
  • Bora Bora, French Polynesia
  • Papeete, Tahiti
View more ports

Ports

Miami, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Corinto, Nicaragua - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - Hilo, Hawaii - Kahului, Maui - Honolulu, Oahu - Nawiliwili, Kauai - Lahaina, Maui - Cross International Dateline - Fanning Island, Kiribati - Rangiroa, French Polynesia - Raiatea, French Polynesia - Bora Bora, French Polynesia - Papeete, Tahiti - View more ports

Seven Seas Mariner S

3.9
(97 Reviews)

2026 sail dates:

$24999*
$714/night*
Suite
View Deal
$24999* luxurycruiseconnections.com $24999* luxuryonly.com $24999* cruisesonly.com $24999* cruises.com $24999* dreamvacations.com $24999* americandiscountvacations.com $24999* gotosea.com $24999* americandiscountcruises.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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Ports

  • Port Canaveral, Florida
  • Grand Turk Island
  • Oranjestad, Aruba
  • Willemstad, Curacao
  • Colon, Panama
  • Puerto Limon, Costa Rica
  • Montego Bay, Jamaica
  • George Town, Grand Cayman
View more ports

Ports

Port Canaveral, Florida - Grand Turk Island - Oranjestad, Aruba - Willemstad, Curacao - Colon, Panama - Puerto Limon, Costa Rica - Montego Bay, Jamaica - George Town, Grand Cayman - View more ports

Carnival Venezia XL

4.1
(246 Reviews)

2026 sail dates:

$1419*
$101/night*
Inside
View Deal
$1419* cheapcruises.com $1419* cruises.com $1419* cruisesonly.com $1419* dreamvacations.com $1419* americandiscountvacations.com $1419* americandiscountcruises.com
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161 - 170 of 329

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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