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American Cruise Line Cruises to River Cruises - United States 125 cruises on American Cruise Line found

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125 cruises found

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Ports

  • Clarkston, Washington
  • CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA
  • Pendleton, Oregon
  • THE DALLES, OREGON
  • Cruise Columbia River
  • Mount St. Helens, Washington
  • Astoria, Oregon
  • Portland, Oregon
View more ports

Ports

Clarkston, Washington - CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA - Pendleton, Oregon - THE DALLES, OREGON - Cruise Columbia River - Mount St. Helens, Washington - Astoria, Oregon - Portland, Oregon - View more ports

American West S

5.0
(1 Reviews)

2025 sail dates: May 12, Jun 09, Jun 23, Jul 07, Jul 21, Aug 04, Aug 18, Sep 01, Sep 15, Sep 29, Oct 13 More

$4925*
$704/night*
Oceanview
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$4925* luxuryonly.com $4925* dreamvacations.com
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Ports

  • Seattle, Washington
  • ANACORTES, WASHINGTON
  • FRIDAY HARBOR, SAN JUAN ISLAND, WASHINGTON
  • CRUISE SAN JUAN ISLANDS
  • Victoria, British Columbia
  • PORT TOWNSEND, WASHINGTON
  • POULSBO, WA
View more ports

Ports

Seattle, Washington - ANACORTES, WASHINGTON - FRIDAY HARBOR, SAN JUAN ISLAND, WASHINGTON - CRUISE SAN JUAN ISLANDS - Victoria, British Columbia - PORT TOWNSEND, WASHINGTON - POULSBO, WA - View more ports

American Spirit S

4.7
(11 Reviews)

2025 sail dates: May 17, May 24, May 31, Jun 07, Jun 14, Jun 21, Jun 28, Jul 05, Jul 12, Jul 19, Jul 26, Aug 02, Aug 09, Aug 16, Aug 23, Aug 30, Sep 06, Sep 13, Sep 20 More

2026 sail dates: Jun 06, Jun 13, Jun 20, Jun 27, Jul 04, Jul 11, Jul 18, Jul 25, Aug 01, Aug 08, Aug 15, Aug 22, Sep 05, Sep 12, Sep 19, More

$4925*
$704/night*
Oceanview
View Deal
$4925* luxuryonly.com $4925* dreamvacations.com
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Read all 11 American Spirit reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
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$4925*

$5865*

$7795*

 

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Ports

  • Amelia Island, Florida
  • JEKYLL ISLAND, GEORGIA
  • ST. SIMONS ISLAND, GEORGIA
  • Savannah, Georgia
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • BEAUFORT, SOUTH CAROLINA
  • RIVER CRUISING
  • Charleston, South Carolina
  • Wilmington, North Carolina
  • BEAUFORT, NORTH CAROLINA
  • KITTY HAWK, NORTH CAROLINA
  • Norfolk, Virginia
  • ST. MICHAELS, MARYLAND
  • Baltimore, Maryland
View more ports

Ports

Amelia Island, Florida - JEKYLL ISLAND, GEORGIA - ST. SIMONS ISLAND, GEORGIA - Savannah, Georgia - HILTON HEAD ISLAND, SOUTH CAROLINA - BEAUFORT, SOUTH CAROLINA - RIVER CRUISING - Charleston, South Carolina - Wilmington, North Carolina - BEAUFORT, NORTH CAROLINA - KITTY HAWK, NORTH CAROLINA - Norfolk, Virginia - ST. MICHAELS, MARYLAND - Baltimore, Maryland - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates:

2026 sail dates:

$10585*
$756/night*
Oceanview
View Deal
$10585* luxuryonly.com $10585* dreamvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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N/A

$10585*

$12360*

$16325*

 

N/A

$10585*

$12360*

$16325*

Ports

  • Amelia Island, Florida
  • JEKYLL ISLAND, GEORGIA
  • ST. SIMONS ISLAND, GEORGIA
  • Savannah, Georgia
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • BEAUFORT, SOUTH CAROLINA
  • RIVER CRUISING
  • Charleston, South Carolina
  • Wilmington, North Carolina
  • BEAUFORT, NORTH CAROLINA
  • KITTY HAWK, NORTH CAROLINA
  • Norfolk, Virginia
  • ST. MICHAELS, MARYLAND
  • Baltimore, Maryland
View more ports

Ports

Amelia Island, Florida - JEKYLL ISLAND, GEORGIA - ST. SIMONS ISLAND, GEORGIA - Savannah, Georgia - HILTON HEAD ISLAND, SOUTH CAROLINA - BEAUFORT, SOUTH CAROLINA - RIVER CRUISING - Charleston, South Carolina - Wilmington, North Carolina - BEAUFORT, NORTH CAROLINA - KITTY HAWK, NORTH CAROLINA - Norfolk, Virginia - ST. MICHAELS, MARYLAND - Baltimore, Maryland - View more ports

American Liberty XL

5.0
(1 Reviews)

2025 sail dates:

2026 sail dates: May 23

$11360*
$811/night*
Balcony
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$11360* luxuryonly.com $11360* dreamvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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$11360*

$15325*

 

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$11360*

$15325*

See Offers

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$12360*

$16325*

 

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$12360*

$16325*

Ports

  • Juneau, Alaska
  • Haines, Alaska
  • Cruise Glacier Bay
  • PETERSBURG, ALASKA
  • Wrangell, Alaska
  • Cruise Tracy Arm Fjord, Alaska
View more ports

Ports

Juneau, Alaska - Haines, Alaska - Cruise Glacier Bay - PETERSBURG, ALASKA - Wrangell, Alaska - Cruise Tracy Arm Fjord, Alaska - View more ports

American Constitution XL

5.0
(4 Reviews)

2025 sail dates: May 24, May 31, Jul 07, Jul 14, Jul 21, Aug 04, Aug 11 More

$6125*
$875/night*
Oceanview
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$6125* luxuryonly.com $6125* dreamvacations.com
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Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • Greenville, Mississippi
  • Memphis, Tennessee
  • New Madrid, Missouri
  • Cape Girardeau, Missouri
  • CHESTER, ILLINOIS
  • St. Louis, Missouri
  • RIVER CRUISING
  • Hannibal, Missouri
  • FORT MADISON, IOWA
  • DAVENPORT, IOWA
  • Dubuque, Iowa
  • Winona, Minnesota
  • Red Wing, Minnesota
  • St. Paul, Minnesota
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - Greenville, Mississippi - Memphis, Tennessee - New Madrid, Missouri - Cape Girardeau, Missouri - CHESTER, ILLINOIS - St. Louis, Missouri - RIVER CRUISING - Hannibal, Missouri - FORT MADISON, IOWA - DAVENPORT, IOWA - Dubuque, Iowa - Winona, Minnesota - Red Wing, Minnesota - St. Paul, Minnesota - View more ports

American Melody S

5.0
(8 Reviews)

2025 sail dates:

2026 sail dates: May 23

$14890*
$709/night*
Balcony
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$14890* luxuryonly.com $14890* dreamvacations.com
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$14890*

$20790*

 

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$20790*

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$15890*

$21790*

 

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$15890*

$21790*

Ports

  • New York, New York
  • OLD SAYBROOK, CONNECTICUT
  • New London, Connecticut
  • Newport, Rhode Island
  • Plymouth, Massachusetts
  • Boston, Massachusetts
View more ports

Ports

New York, New York - OLD SAYBROOK, CONNECTICUT - New London, Connecticut - Newport, Rhode Island - Plymouth, Massachusetts - Boston, Massachusetts - View more ports

American Independence S

4.6
(8 Reviews)

2025 sail dates:

2026 sail dates:

$4840*
$691/night*
Oceanview
View Deal
$4840* luxuryonly.com $4840* dreamvacations.com
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Read all 8 American Independence reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

$4840*

$5840*

$7890*

 

N/A

$4840*

$5840*

$7890*

Ports

  • Juneau, Alaska
  • Haines, Alaska
  • Cruise Glacier Bay
  • PETERSBURG, ALASKA
  • Wrangell, Alaska
  • Cruise Tracy Arm Fjord, Alaska
View more ports

Ports

Juneau, Alaska - Haines, Alaska - Cruise Glacier Bay - PETERSBURG, ALASKA - Wrangell, Alaska - Cruise Tracy Arm Fjord, Alaska - View more ports

American Constellation S

4.9
(7 Reviews)

2025 sail dates: May 26, Jun 02, Jun 09, Jul 16, Jul 23, Aug 19, Aug 26, Sep 02, More

2026 sail dates: May 25, Jun 01, Jun 08, Jul 15, Jul 22, Aug 18, Aug 25, Sep 01, Sep 08 More

$5900*
$843/night*
Oceanview
View Deal
$5900* luxuryonly.com $5900* dreamvacations.com
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Ports

  • PROVIDENCE, RHODE ISLAND
  • NEW BEDFORD, MASSACHUSETTS
  • NANTUCKET, MASSACHUSETTS
  • Martha's Vineyard, Massachusetts
  • BLOCK ISLAND, RHODE ISLAND
  • Newport, Rhode Island
  • BRISTOL, RI
View more ports

Ports

PROVIDENCE, RHODE ISLAND - NEW BEDFORD, MASSACHUSETTS - NANTUCKET, MASSACHUSETTS - Martha's Vineyard, Massachusetts - BLOCK ISLAND, RHODE ISLAND - Newport, Rhode Island - BRISTOL, RI - View more ports

American Star S

4.5
(9 Reviews)

2025 sail dates: May 31, Jun 07, Jun 14, Jun 21, Jun 28, Jul 12, Jul 19, Jul 26, Aug 02, Aug 09, Aug 16, Aug 23, Aug 30, Sep 06, Sep 13, Sep 20 More

2026 sail dates:

$4840*
$691/night*
Oceanview
View Deal
$4840* luxuryonly.com $4840* dreamvacations.com
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Read all 9 American Star reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

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$4940*

$5940*

$7990*

 

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$5940*

$7990*

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$5240*

$6240*

$8290*

 

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$4840*

$5840*

$7890*

 

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$5840*

$7890*

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$5240*

$6240*

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$5555*

$6615*

$8785*

 

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$6615*

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$5870*

$6990*

$9285*

 

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$6990*

$9285*

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$9285*

Ports

  • Baltimore, Maryland
  • Yorktown, Virginia
  • Williamsburg, Virginia
  • CAMBRIDGE, MARYLAND
  • ST. MICHAELS, MARYLAND
  • ANNAPOLIS, MARYLAND
View more ports

Ports

Baltimore, Maryland - Yorktown, Virginia - Williamsburg, Virginia - CAMBRIDGE, MARYLAND - ST. MICHAELS, MARYLAND - ANNAPOLIS, MARYLAND - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates:

$5490*
$784/night*
Oceanview
View Deal
$5490* luxuryonly.com $5490* dreamvacations.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

$5490*

$6495*

$8815*

 

N/A

$5490*

$6495*

$8815*

61 - 70 of 125

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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