Cruises on American Cruise Line 48 cruises on American Cruise Line found

Your search Clear selections

Any Destination
All Sail Months
Any Length
Any Port
American Cruise Line
Any Ship

Close

48 cruises found

Sort by

Filter by

More

Ports

  • Pittsburgh, Pennsylvania
  • MARIETTA, OHIO
  • MAYSVILLE, KENTUCKY
  • Cincinnati, Ohio
  • Louisville, Kentucky
  • Henderson, Kentucky
  • Paducah, Kentucky
  • Cape Girardeau, Missouri
  • St. Louis, Missouri
View more ports

Ports

Pittsburgh, Pennsylvania - MARIETTA, OHIO - MAYSVILLE, KENTUCKY - Cincinnati, Ohio - Louisville, Kentucky - Henderson, Kentucky - Paducah, Kentucky - Cape Girardeau, Missouri - St. Louis, Missouri - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

$5750*

$6480*

$9435*

See Offers

N/A

$5750*

$6480*

$9435*

See Offers

N/A

$5750*

$6480*

$9435*

See Offers

N/A

$5750*

$6480*

$9435*

Ports

  • Portland, Oregon
  • Astoria, Oregon
  • Mount St. Helens, Washington
  • STEVENSON, WASHINGTON
  • HOOD RIVER, OREGON
  • THE DALLES, OREGON
  • RICHLAND (TRI-CITIES), WASHINGTON
  • Pendleton, Oregon
  • Clarkston, Washington
View more ports

Ports

Portland, Oregon - Astoria, Oregon - Mount St. Helens, Washington - STEVENSON, WASHINGTON - HOOD RIVER, OREGON - THE DALLES, OREGON - RICHLAND (TRI-CITIES), WASHINGTON - Pendleton, Oregon - Clarkston, Washington - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

N/A

$8300*

$11645*

See Offers

N/A

N/A

$8300*

$11645*

See Offers

N/A

N/A

$8300*

$11645*

See Offers

N/A

N/A

$8300*

$11645*

Ports

  • Clarkston, Washington
  • Pendleton, Oregon
  • THE DALLES, OREGON
  • Cruise Columbia River
  • Mount St. Helens, Washington
  • Astoria, Oregon
  • Portland, Oregon
View more ports

Ports

Clarkston, Washington - Pendleton, Oregon - THE DALLES, OREGON - Cruise Columbia River - Mount St. Helens, Washington - Astoria, Oregon - Portland, Oregon - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Ports

  • St. Louis, Missouri
  • Hannibal, Missouri
  • FORT MADISON, IOWA
  • DAVENPORT, IOWA
  • Dubuque, Iowa
  • La Crosse, Wisconsin
  • Red Wing, Minnesota
  • St. Paul, Minnesota
View more ports

Ports

St. Louis, Missouri - Hannibal, Missouri - FORT MADISON, IOWA - DAVENPORT, IOWA - Dubuque, Iowa - La Crosse, Wisconsin - Red Wing, Minnesota - St. Paul, Minnesota - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

See Offers

N/A

N/A

$5170*

$6940*

Ports

  • Clarkston, Washington
  • Pendleton, Oregon
  • THE DALLES, OREGON
  • Cruise Columbia River
  • Mount St. Helens, Washington
  • Astoria, Oregon
  • Portland, Oregon
View more ports

Ports

Clarkston, Washington - Pendleton, Oregon - THE DALLES, OREGON - Cruise Columbia River - Mount St. Helens, Washington - Astoria, Oregon - Portland, Oregon - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Ports

  • Seattle, Washington
  • ANACORTES, WASHINGTON
  • FRIDAY HARBOR, SAN JUAN ISLAND, WASHINGTON
  • Victoria, British Columbia
  • PORT TOWNSEND, WASHINGTON
  • POULSBO, WA
View more ports

Ports

Seattle, Washington - ANACORTES, WASHINGTON - FRIDAY HARBOR, SAN JUAN ISLAND, WASHINGTON - Victoria, British Columbia - PORT TOWNSEND, WASHINGTON - POULSBO, WA - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Ports

  • St. Louis, Missouri
  • Hannibal, Missouri
  • FORT MADISON, IOWA
  • DAVENPORT, IOWA
  • Dubuque, Iowa
  • La Crosse, Wisconsin
  • Red Wing, Minnesota
  • St. Paul, Minnesota
View more ports

Ports

St. Louis, Missouri - Hannibal, Missouri - FORT MADISON, IOWA - DAVENPORT, IOWA - Dubuque, Iowa - La Crosse, Wisconsin - Red Wing, Minnesota - St. Paul, Minnesota - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Ports

  • New York, New York
  • WEST POINT, NEW YORK
  • KINGSTON, NY
  • HYDE PARK, NY
  • TROY, NEW YORK
  • CATSKILL, NEW YORK
  • SLEEPY HOLLOW, NEW YORK
View more ports

Ports

New York, New York - WEST POINT, NEW YORK - KINGSTON, NY - HYDE PARK, NY - TROY, NEW YORK - CATSKILL, NEW YORK - SLEEPY HOLLOW, NEW YORK - View more ports

Ports

  • Portland, Oregon
  • Astoria, Oregon
  • Mount St. Helens, Washington
  • Cruise Columbia River
  • THE DALLES, OREGON
  • Pendleton, Oregon
  • Clarkston, Washington
View more ports

Ports

Portland, Oregon - Astoria, Oregon - Mount St. Helens, Washington - Cruise Columbia River - THE DALLES, OREGON - Pendleton, Oregon - Clarkston, Washington - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

$4400*

$5400*

$7295*

See Offers

N/A

$4400*

$5400*

$7295*

See Offers

N/A

$4400*

$5400*

$7295*

See Offers

N/A

$4400*

$5400*

$7295*

See Offers

N/A

$4125*

$5055*

$6835*

See Offers

N/A

$4125*

$5055*

$6835*

See Offers

N/A

$4125*

$5055*

$6835*

See Offers

N/A

$4125*

$5055*

$6835*

Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • St. Francisville, Louisiana
  • Baton Rouge, Louisiana
  • Houmas House Plantation, Louisiana
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Natchez, Mississippi - Vicksburg, Mississippi - St. Francisville, Louisiana - Baton Rouge, Louisiana - Houmas House Plantation, Louisiana - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

N/A

$5485*

$7365*

See Offers

N/A

N/A

$5485*

$7365*

See Offers

N/A

N/A

$5485*

$7365*

See Offers

N/A

N/A

$5485*

$7365*