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Cruises on American Cruise Line 160 cruises on American Cruise Line found

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Ports

  • Portland, Oregon
  • HAYDEN ISLAND, PORTLAND, OREGON
  • Astoria, Oregon
  • Mount St. Helens, Washington
  • Cruise Columbia River
  • THE DALLES, OREGON
  • Pendleton, Oregon
  • CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA
  • Clarkston, Washington
View more ports

Ports

Portland, Oregon - HAYDEN ISLAND, PORTLAND, OREGON - Astoria, Oregon - Mount St. Helens, Washington - Cruise Columbia River - THE DALLES, OREGON - Pendleton, Oregon - CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA - Clarkston, Washington - View more ports

American Harmony S

5.0
(6 Reviews)

2024 sail dates:

2025 sail dates: Apr 26, May 10, May 24, Jun 07, Jun 21, Jul 05, Jul 19, Aug 02, Aug 16, Aug 30, Sep 13, Sep 27, Oct 11, Oct 25, More

$5995*
$856/night*
Balcony
View Deal
$5995* dreamvacations.com $5995* luxuryonly.com
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Top positive review

Top critical review

Read all 6 American Harmony reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

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Ports

  • Memphis, Tennessee
  • RIVER CRUISING
  • Vicksburg, Mississippi
  • Natchez, Mississippi
  • St. Francisville, Louisiana
  • Baton Rouge, Louisiana
  • Houmas House Plantation, Louisiana
  • New Orleans, Louisiana
View more ports

Ports

Memphis, Tennessee - RIVER CRUISING - Vicksburg, Mississippi - Natchez, Mississippi - St. Francisville, Louisiana - Baton Rouge, Louisiana - Houmas House Plantation, Louisiana - New Orleans, Louisiana - View more ports

American Symphony S

4.2
(4 Reviews)

2024 sail dates: Dec 07, Dec 30

2025 sail dates: Jul 02, Jul 16, Nov 05, More

$4915*
$702/night*
Balcony
View Deal
$4915* dreamvacations.com $4915* luxuryonly.com
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Top positive review

Top critical review

Read all 4 American Symphony reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5275*

$7295*

 

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Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Baton Rouge, Louisiana
  • Natchez, Mississippi
  • St. Francisville, Louisiana
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Baton Rouge, Louisiana - Natchez, Mississippi - St. Francisville, Louisiana - View more ports

American Melody S

5.0
(8 Reviews)

2024 sail dates:

2025 sail dates: Mar 11, Mar 17, Mar 23,

$4255*
$709/night*
Balcony
View Deal
$4255* dreamvacations.com $4255* luxuryonly.com
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Top positive review

Top critical review

Read all 8 American Melody reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$4565*

$6315*

 

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Ports

  • Charleston, South Carolina
  • BEAUFORT, SOUTH CAROLINA
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • Savannah, Georgia
  • JEKYLL ISLAND, GEORGIA
  • Amelia Island, Florida
  • Jacksonville, Florida
View more ports

Ports

Charleston, South Carolina - BEAUFORT, SOUTH CAROLINA - HILTON HEAD ISLAND, SOUTH CAROLINA - Savannah, Georgia - JEKYLL ISLAND, GEORGIA - Amelia Island, Florida - Jacksonville, Florida - View more ports

American Liberty XL

5.0
(1 Reviews)

2024 sail dates: Dec 07, Dec 21

2025 sail dates: Feb 08, Feb 22, Mar 08, Mar 22, Apr 05, Apr 19, May 03, May 17, Nov 22, Dec 06, Dec 20 More

$6575*
$939/night*
Balcony
View Deal
$6575* dreamvacations.com $6575* luxuryonly.com
Loading itinerary...
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$8755*

 

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Ports

  • ST. PETERSBURG, FLORIDA
  • MARCO ISLAND, FLORIDA
  • Key West, Florida
  • PUNTA GORDA, FLORIDA
View more ports

Ports

ST. PETERSBURG, FLORIDA - MARCO ISLAND, FLORIDA - Key West, Florida - PUNTA GORDA, FLORIDA - View more ports

American Glory S

5.0
(1 Reviews)

2024 sail dates:

2025 sail dates: Feb 01

$5630*
$804/night*
Oceanview
View Deal
$5630* dreamvacations.com $5630* luxuryonly.com
Loading itinerary...
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$6350*

$7415*

$9875*

 

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Ports

  • Jacksonville, Florida
  • Amelia Island, Florida
  • JEKYLL ISLAND, GEORGIA
  • Savannah, Georgia
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • BEAUFORT, SOUTH CAROLINA
  • Charleston, South Carolina
View more ports

Ports

Jacksonville, Florida - Amelia Island, Florida - JEKYLL ISLAND, GEORGIA - Savannah, Georgia - HILTON HEAD ISLAND, SOUTH CAROLINA - BEAUFORT, SOUTH CAROLINA - Charleston, South Carolina - View more ports

American Eagle S

5.0
(2 Reviews)

2024 sail dates: Dec 08, Dec 22

2025 sail dates: Mar 24, Apr 07, Apr 21, May 05, Dec 05, More

$5630*
$804/night*
Oceanview
View Deal
$5630* dreamvacations.com $5630* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5630*

$6575*

$8755*

 

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Ports

  • ST. PETERSBURG, FLORIDA
  • FORT MYERS, FLORIDA
  • Key West, Florida
  • MARCO ISLAND, FLORIDA
  • PUNTA GORDA, FLORIDA
View more ports

Ports

ST. PETERSBURG, FLORIDA - FORT MYERS, FLORIDA - Key West, Florida - MARCO ISLAND, FLORIDA - PUNTA GORDA, FLORIDA - View more ports

American Legend S

2024 sail dates: Dec 09, Dec 16, Dec 23, Dec 30 More

2025 sail dates: Jan 13, Jan 20, Jan 27, Feb 03, Feb 10, Feb 17, More

$6995*
$999/night*
Balcony
View Deal
$6995* dreamvacations.com $6995* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$9315*

 

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Ports

  • Charleston, South Carolina
  • BEAUFORT, SOUTH CAROLINA
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • Savannah, Georgia
  • JEKYLL ISLAND, GEORGIA
  • Amelia Island, Florida
  • Jacksonville, Florida
View more ports

Ports

Charleston, South Carolina - BEAUFORT, SOUTH CAROLINA - HILTON HEAD ISLAND, SOUTH CAROLINA - Savannah, Georgia - JEKYLL ISLAND, GEORGIA - Amelia Island, Florida - Jacksonville, Florida - View more ports

American Independence S

4.6
(8 Reviews)

2024 sail dates:

2025 sail dates: Apr 12,

$4610*
$659/night*
Oceanview
View Deal
$4610* dreamvacations.com $4610* luxuryonly.com
Loading itinerary...
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Top positive review

Top critical review

Read all 8 American Independence reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$4610*

$5490*

$7295*

 

N/A

$4610*

$5490*

$7295*

 

N/A

$4925*

$5865*

$7795*

 

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$4925*

$5865*

$7795*

Ports

  • Clarkston, Washington
  • CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA
  • Pendleton, Oregon
  • THE DALLES, OREGON
  • Cruise Columbia River
  • Mount St. Helens, Washington
  • Astoria, Oregon
  • Portland, Oregon
View more ports

Ports

Clarkston, Washington - CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA - Pendleton, Oregon - THE DALLES, OREGON - Cruise Columbia River - Mount St. Helens, Washington - Astoria, Oregon - Portland, Oregon - View more ports

American Harmony S

5.0
(6 Reviews)

2024 sail dates:

2025 sail dates: Apr 19, May 03, May 17, May 31, Jun 14, Jun 28, Jul 12, Jul 26, Aug 09, Aug 23, Sep 06, Sep 20, Oct 04, Oct 18, Nov 01, More

$5995*
$856/night*
Balcony
View Deal
$5995* dreamvacations.com $5995* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 6 American Harmony reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5995*

$8290*

 

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Ports

  • Jacksonville, Florida
  • Amelia Island, Florida
  • JEKYLL ISLAND, GEORGIA
  • Savannah, Georgia
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • BEAUFORT, SOUTH CAROLINA
  • Charleston, South Carolina
View more ports

Ports

Jacksonville, Florida - Amelia Island, Florida - JEKYLL ISLAND, GEORGIA - Savannah, Georgia - HILTON HEAD ISLAND, SOUTH CAROLINA - BEAUFORT, SOUTH CAROLINA - Charleston, South Carolina - View more ports

American Liberty XL

5.0
(1 Reviews)

2024 sail dates: Dec 14, Dec 28

2025 sail dates: Feb 15, Mar 01, Mar 15, Mar 29, Apr 12, Apr 26, May 10, Nov 15, Nov 29, Dec 27, More

$6575*
$939/night*
Balcony
View Deal
$6575* dreamvacations.com $6575* luxuryonly.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
 

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All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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