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New Orleans, Louisiana Cruises with American Cruise Line 15 cruises on American Cruise Line found

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Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Baton Rouge, Louisiana
  • Natchez, Mississippi
  • St. Francisville, Louisiana
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Baton Rouge, Louisiana - Natchez, Mississippi - St. Francisville, Louisiana - View more ports

American Heritage S

4.8
(7 Reviews)

2025 sail dates: Oct 11, Oct 17, Oct 23, Oct 29, Nov 04, Nov 10, More

2026 sail dates: Mar 29, Apr 04, Apr 10, Apr 16, Apr 22, Apr 28, May 04, May 10, May 16, May 22, May 28 More

$3630*
$605/night*
Oceanview
View Deal
$3630* dreamvacations.com $3630* luxuryonly.com
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Read all 7 American Heritage reviews

Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Baton Rouge, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • St. Francisville, Louisiana
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Baton Rouge, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - St. Francisville, Louisiana - View more ports

American Serenade S

2025 sail dates: Oct 11

2026 sail dates:

$4880*
$813/night*
Balcony
View Deal
$4880* dreamvacations.com $4880* luxuryonly.com
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

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$4880*

$6745*

See Offers

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$4880*

$6745*

 

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$4880*

$6745*

See Offers

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$4880*

$6745*

Ports

  • New Orleans, Louisiana
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • RIVER CRUISING
  • Memphis, Tennessee
View more ports

Ports

New Orleans, Louisiana - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - RIVER CRUISING - Memphis, Tennessee - View more ports

American Symphony S

4.2
(4 Reviews)

2024 sail dates: Nov 30, Dec 22

2025 sail dates: Sep 03,

$4915*
$702/night*
Balcony
View Deal
$4915* dreamvacations.com $4915* luxuryonly.com
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Top positive review

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Read all 4 American Symphony reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5275*

$7295*

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$4915*

$6800*

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Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Baton Rouge, Louisiana
  • Natchez, Mississippi
  • St. Francisville, Louisiana
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Baton Rouge, Louisiana - Natchez, Mississippi - St. Francisville, Louisiana - View more ports

American Melody S

5.0
(8 Reviews)

2024 sail dates:

2025 sail dates: Mar 11, Mar 17, Mar 23,

$4255*
$709/night*
Balcony
View Deal
$4255* dreamvacations.com $4255* luxuryonly.com
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Top positive review

Top critical review

Read all 8 American Melody reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$4565*

$6315*

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$4565*

$6315*

 

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$4565*

$6315*

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$6315*

 

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$6315*

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$6315*

 

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$4255*

$5885*

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$4255*

$5885*

Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Baton Rouge, Louisiana
  • Natchez, Mississippi
  • St. Francisville, Louisiana
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Baton Rouge, Louisiana - Natchez, Mississippi - St. Francisville, Louisiana - View more ports

American Symphony S

4.2
(4 Reviews)

2024 sail dates:

$4255*
$709/night*
Balcony
View Deal
$4255* dreamvacations.com $4255* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 4 American Symphony reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$4255*

$5885*

See Offers

N/A

N/A

$4255*

$5885*

Ports

  • New Orleans, Louisiana
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • RIVER CRUISING
  • Memphis, Tennessee
View more ports

Ports

New Orleans, Louisiana - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - RIVER CRUISING - Memphis, Tennessee - View more ports

American Melody S

5.0
(8 Reviews)

2024 sail dates:

2025 sail dates: Mar 29, Apr 12, Apr 26, May 10, More

$5275*
$754/night*
Balcony
View Deal
$5275* dreamvacations.com $5275* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 8 American Melody reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$5635*

$7795*

See Offers

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$5635*

$7795*

 

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$5995*

$8290*

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$8290*

 

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$5275*

$7295*

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$5995*

$8290*

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$5995*

$8290*

 

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$5275*

$7295*

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$5275*

$7295*

Ports

  • New Orleans, Louisiana
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • RIVER CRUISING
  • Memphis, Tennessee
View more ports

Ports

New Orleans, Louisiana - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - RIVER CRUISING - Memphis, Tennessee - View more ports

American Serenade S

2025 sail dates: Feb 22, Mar 08, Mar 22, Apr 05, Apr 19, May 03, May 17, May 31, Aug 30, Sep 13, More

2026 sail dates: Mar 07, Mar 21, Apr 18, May 02, May 16, May 30, Aug 29, Sep 12, More

$5275*
$754/night*
Balcony
View Deal
$5275* dreamvacations.com $5275* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$5275*

$7295*

See Offers

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$5275*

$7295*

 

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$5635*

$7795*

See Offers

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$5635*

$7795*

 

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$5635*

$7795*

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$5635*

$7795*

 

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$8290*

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$8290*

 

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$5635*

$7795*

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$7795*

 

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$7795*

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$7795*

 

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$5275*

$7295*

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$7295*

 

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$5635*

$7795*

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$8290*

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$5635*

$7795*

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$5635*

$7795*

 

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$5635*

$7795*

See Offers

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N/A

$5635*

$7795*

Ports

  • New Orleans, Louisiana
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • RIVER CRUISING
  • Memphis, Tennessee
View more ports

Ports

New Orleans, Louisiana - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - RIVER CRUISING - Memphis, Tennessee - View more ports

American Splendor S

4.1
(4 Reviews)

2025 sail dates: Mar 12, Mar 26, Apr 09, Apr 23, May 07, May 21, Jun 04, Jul 16, Nov 05 More

2026 sail dates: Feb 25, Mar 11, Mar 25, Apr 08, Apr 22, May 06, May 20, Jun 03 More

$4295*
$614/night*
Oceanview
View Deal
$4295* dreamvacations.com $4295* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 4 American Splendor reviews

Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • Greenville, Mississippi
  • Memphis, Tennessee
  • New Madrid, Missouri
  • Cape Girardeau, Missouri
  • CHESTER, ILLINOIS
  • St. Louis, Missouri
  • RIVER CRUISING
  • Hannibal, Missouri
  • FORT MADISON, IOWA
  • DAVENPORT, IOWA
  • Dubuque, Iowa
  • Winona, Minnesota
  • Red Wing, Minnesota
  • St. Paul, Minnesota
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - Greenville, Mississippi - Memphis, Tennessee - New Madrid, Missouri - Cape Girardeau, Missouri - CHESTER, ILLINOIS - St. Louis, Missouri - RIVER CRUISING - Hannibal, Missouri - FORT MADISON, IOWA - DAVENPORT, IOWA - Dubuque, Iowa - Winona, Minnesota - Red Wing, Minnesota - St. Paul, Minnesota - View more ports

American Melody S

5.0
(8 Reviews)

2025 sail dates:

2026 sail dates: May 23

$15890*
$757/night*
Balcony
View Deal
$15890* dreamvacations.com $15890* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 8 American Melody reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$15890*

$21790*

See Offers

N/A

N/A

$15890*

$21790*

 

N/A

N/A

$15890*

$21790*

See Offers

N/A

N/A

$15890*

$21790*

Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • Greenville, Mississippi
  • Memphis, Tennessee
  • New Madrid, Missouri
  • Cape Girardeau, Missouri
  • CHESTER, ILLINOIS
  • St. Louis, Missouri
  • RIVER CRUISING
  • Hannibal, Missouri
  • FORT MADISON, IOWA
  • DAVENPORT, IOWA
  • Dubuque, Iowa
  • Winona, Minnesota
  • Red Wing, Minnesota
  • St. Paul, Minnesota
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - Greenville, Mississippi - Memphis, Tennessee - New Madrid, Missouri - Cape Girardeau, Missouri - CHESTER, ILLINOIS - St. Louis, Missouri - RIVER CRUISING - Hannibal, Missouri - FORT MADISON, IOWA - DAVENPORT, IOWA - Dubuque, Iowa - Winona, Minnesota - Red Wing, Minnesota - St. Paul, Minnesota - View more ports

American Serenade S

2025 sail dates: Jun 14

2026 sail dates:

$15890*
$757/night*
Balcony
View Deal
$15890* dreamvacations.com $15890* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$15890*

$21790*

See Offers

N/A

N/A

$15890*

$21790*

 

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$15890*

$21790*

See Offers

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$15890*

$21790*

1 - 10 of 15

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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