Colon, Panama cruises 225 Colon, Panama cruises

Your search Clear selections

Any Destination
All Sail Months
Any Length
Colon, Panama
Any Cruise Line
Any Ship

Close

225 cruises found

Sort by

Filter by

More

Ports

  • San Juan, Puerto Rico
  • Cruz Bay, St. John, U.S.V.I.
  • St. John's, Antigua
  • Terre-De-Haut, Iles Des Saintes, Guadeloupe
  • Pigeon Island, St. Lucia
  • St. George's, Grenada
  • Gustavia, St. Barthelemy
  • Jost Van Dyke, B.V.I.
  • Prickly Pear Island, B.V.I.
  • Catalina Island (Isla Catalina), Dominican Republic
  • Santo Domingo, Dominican Republic
  • Cartagena, Colombia
  • San Blas Islands, Panama
  • Colon, Panama
  • Panama Canal Transit
  • Balboa, Panama
  • ISLA PARIDA, PANAMA
  • GOLFO DULCE, COSTA RICA
  • Puerto Quepos, Costa Rica
  • Puerto Caldera, Costa Rica
View more ports

Ports

San Juan, Puerto Rico - Cruz Bay, St. John, U.S.V.I. - St. John's, Antigua - Terre-De-Haut, Iles Des Saintes, Guadeloupe - Pigeon Island, St. Lucia - St. George's, Grenada - Gustavia, St. Barthelemy - Jost Van Dyke, B.V.I. - Prickly Pear Island, B.V.I. - Catalina Island (Isla Catalina), Dominican Republic - Santo Domingo, Dominican Republic - Cartagena, Colombia - San Blas Islands, Panama - Colon, Panama - Panama Canal Transit - Balboa, Panama - ISLA PARIDA, PANAMA - GOLFO DULCE, COSTA RICA - Puerto Quepos, Costa Rica - Puerto Caldera, Costa Rica - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

N/A

$8538*

 

N/A

N/A

N/A

$8643*

See Offers

N/A

N/A

N/A

$8643*

Ports

  • San Juan, Puerto Rico
  • Cruz Bay, St. John, U.S.V.I.
  • St. John's, Antigua
  • Terre-De-Haut, Iles Des Saintes, Guadeloupe
  • Pigeon Island, St. Lucia
  • St. George's, Grenada
  • Gustavia, St. Barthelemy
  • Jost Van Dyke, B.V.I.
  • Prickly Pear Island, B.V.I.
  • Catalina Island (Isla Catalina), Dominican Republic
  • Santo Domingo, Dominican Republic
  • Cartagena, Colombia
  • San Blas Islands, Panama
  • Colon, Panama
  • Panama Canal Transit
  • Balboa, Panama
  • ISLA PARIDA, PANAMA
  • GOLFO DULCE, COSTA RICA
  • Puerto Quepos, Costa Rica
  • Puerto Caldera, Costa Rica
  • Curu (Reserve), Costa Rica
  • Playas Del Coco, Costa Rica
  • Puerto Chiapas (Tapachula), Mexico
  • Huatulco, Mexico
  • Manzanillo, Mexico
  • Puerto Vallarta, Mexico
  • Seattle, Washington
  • Vancouver (Canada Place), British Columbia
  • Ketchikan, Alaska
  • Cruise Misty Fjords, Alaska
  • Wrangell, Alaska
  • Sitka, Alaska
  • Haines, Alaska
  • Juneau, Alaska
View more ports

Ports

San Juan, Puerto Rico - Cruz Bay, St. John, U.S.V.I. - St. John's, Antigua - Terre-De-Haut, Iles Des Saintes, Guadeloupe - Pigeon Island, St. Lucia - St. George's, Grenada - Gustavia, St. Barthelemy - Jost Van Dyke, B.V.I. - Prickly Pear Island, B.V.I. - Catalina Island (Isla Catalina), Dominican Republic - Santo Domingo, Dominican Republic - Cartagena, Colombia - San Blas Islands, Panama - Colon, Panama - Panama Canal Transit - Balboa, Panama - ISLA PARIDA, PANAMA - GOLFO DULCE, COSTA RICA - Puerto Quepos, Costa Rica - Puerto Caldera, Costa Rica - Curu (Reserve), Costa Rica - Playas Del Coco, Costa Rica - Puerto Chiapas (Tapachula), Mexico - Huatulco, Mexico - Manzanillo, Mexico - Puerto Vallarta, Mexico - Seattle, Washington - Vancouver (Canada Place), British Columbia - Ketchikan, Alaska - Cruise Misty Fjords, Alaska - Wrangell, Alaska - Sitka, Alaska - Haines, Alaska - Juneau, Alaska - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

N/A

$17843*

 

N/A

N/A

N/A

$17843*

See Offers

N/A

N/A

N/A

$17843*

Ports

  • San Juan, Puerto Rico
  • Cruz Bay, St. John, U.S.V.I.
  • St. John's, Antigua
  • Terre-De-Haut, Iles Des Saintes, Guadeloupe
  • Pigeon Island, St. Lucia
  • St. George's, Grenada
  • Gustavia, St. Barthelemy
  • Jost Van Dyke, B.V.I.
  • Prickly Pear Island, B.V.I.
  • Catalina Island (Isla Catalina), Dominican Republic
  • Santo Domingo, Dominican Republic
  • Cartagena, Colombia
  • San Blas Islands, Panama
  • Colon, Panama
View more ports

Ports

San Juan, Puerto Rico - Cruz Bay, St. John, U.S.V.I. - St. John's, Antigua - Terre-De-Haut, Iles Des Saintes, Guadeloupe - Pigeon Island, St. Lucia - St. George's, Grenada - Gustavia, St. Barthelemy - Jost Van Dyke, B.V.I. - Prickly Pear Island, B.V.I. - Catalina Island (Isla Catalina), Dominican Republic - Santo Domingo, Dominican Republic - Cartagena, Colombia - San Blas Islands, Panama - Colon, Panama - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

N/A

$5684*

 

N/A

N/A

N/A

$6143*

See Offers

N/A

N/A

N/A

$6143*

Ports

  • San Diego, California
  • Cabo San Lucas, Mexico
  • Mazatlan, Mexico
  • Puerto Quetzal, Guatemala
  • Puntarenas, Costa Rica
  • Panama Canal Transit
  • Colon, Panama
  • Cartagena, Colombia
  • George Town, Grand Cayman
  • Ft. Lauderdale (Port Everglades), Florida
View more ports

Ports

San Diego, California - Cabo San Lucas, Mexico - Mazatlan, Mexico - Puerto Quetzal, Guatemala - Puntarenas, Costa Rica - Panama Canal Transit - Colon, Panama - Cartagena, Colombia - George Town, Grand Cayman - Ft. Lauderdale (Port Everglades), Florida - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

$2446*

$2958*

N/A

N/A

See Offers

$2446*

$2958*

N/A

N/A

See Offers

$2406*

$2918*

N/A

N/A

 

$2446*

$2958*

N/A

N/A

See Offers

$2406*

$2918*

N/A

N/A

See Offers

$2447*

$2959*

N/A

N/A

 

$2446*

$2958*

N/A

N/A

See Offers

$2446*

$2958*

N/A

N/A

See Offers

$2447*

$2959*

N/A

N/A

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Cozumel, Mexico
  • Colon, Panama
  • Panama Canal Transit
  • Manta, Ecuador
  • Callao (Lima), Peru
  • Iquique, Chile
  • Valparaiso (Santiago), Chile
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cozumel, Mexico - Colon, Panama - Panama Canal Transit - Manta, Ecuador - Callao (Lima), Peru - Iquique, Chile - Valparaiso (Santiago), Chile - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$8995*

$12995*

 

N/A

N/A

$8995*

$12995*

See Offers

N/A

N/A

$8995*

$12995*

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Cozumel, Mexico
  • Colon, Panama
  • Panama Canal Transit
  • Manta, Ecuador
  • Callao (Lima), Peru
  • Iquique, Chile
  • Valparaiso (Santiago), Chile
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cozumel, Mexico - Colon, Panama - Panama Canal Transit - Manta, Ecuador - Callao (Lima), Peru - Iquique, Chile - Valparaiso (Santiago), Chile - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$8995*

$12995*

 

N/A

N/A

$8995*

$12995*

See Offers

N/A

N/A

$8995*

$12995*

 

N/A

N/A

$9995*

$14995*

 

N/A

N/A

$9995*

$14995*

See Offers

N/A

N/A

$9995*

$14995*

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Half Moon Cay, Bahamas (Private Island)
  • Willemstad, Curacao
  • Cartagena, Colombia
  • Colon, Panama
  • Panama Canal (Cruise Into Canal)
  • Puerto Limon, Costa Rica
  • George Town, Grand Cayman
  • Kralendijk, Bonaire
  • Oranjestad, Aruba
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Willemstad, Curacao - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - Kralendijk, Bonaire - Oranjestad, Aruba - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Half Moon Cay, Bahamas (Private Island)
  • Willemstad, Curacao
  • Cartagena, Colombia
  • Colon, Panama
  • Panama Canal (Cruise Into Canal)
  • Puerto Limon, Costa Rica
  • George Town, Grand Cayman
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Willemstad, Curacao - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

Ports

  • San Pedro (Los Angeles), California
  • Ensenada, Mexico
  • Cabo San Lucas, Mexico
  • Acapulco, Mexico
  • Puerto Quetzal, Guatemala
  • Puerto Corinto, Nicaragua
  • Puntarenas, Costa Rica
  • Panama Canal Transit
  • Colon, Panama
View more ports

Ports

San Pedro (Los Angeles), California - Ensenada, Mexico - Cabo San Lucas, Mexico - Acapulco, Mexico - Puerto Quetzal, Guatemala - Puerto Corinto, Nicaragua - Puntarenas, Costa Rica - Panama Canal Transit - Colon, Panama - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Willemstad, Curacao
  • Kralendijk, Bonaire
  • Oranjestad, Aruba
  • Half Moon Cay, Bahamas (Private Island)
  • Cartagena, Colombia
  • Panama Canal (Cruise Into Canal)
  • Colon, Panama
  • Puerto Limon, Costa Rica
  • Falmouth, Jamaica
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Willemstad, Curacao - Kralendijk, Bonaire - Oranjestad, Aruba - Half Moon Cay, Bahamas (Private Island) - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Falmouth, Jamaica - View more ports

All prices are per person based on double occupancy and do not include port/government fees and gratuities.