Colon, Panama cruises 228 Colon, Panama cruises

Your search Clear selections

Any Destination

All Sail Months

Any Length

Colon, Panama

Any Cruise Line

Any Ship

228 cruises found

Filters Save search

Ports

Colon, Panama
Cartagena, Colombia
Oranjestad, Aruba
Willemstad, Curacao

View more ports

Ports

Colon, Panama - Cartagena, Colombia - Oranjestad, Aruba - Willemstad, Curacao - View more ports

7 Night Southern Caribbean (Colon Roundtrip)

Serenade of the Seas L

4.1

(1797 Reviews)

2025 sail dates: Nov 22

2026 sail dates: Feb 14, Mar 21, Apr 04

$726*

$104/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1797 Serenade of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$851*	$938*	$1063*	$1413*
See Offers	$851*	$938*	$1063*	$1413*
See Offers	$851*	$938*	$1063*	$1413*
See Offers	$851*	$939*	$1064*	$1413*
	$851*	$938*	$1063*	$1413*
	$846*	$933*	$1058*	$1408*
See Offers	$851*	$939*	$1064*	$1413*
See Offers	$852*	$939*	$1064*	$1414*
See Offers	$726*	$825*	$1039*	$1455*
See Offers	$726*	$825*	$1039*	$1455*
See Offers	$726*	$825*	$1039*	$1455*
See Offers	$726*	$826*	$1040*	$1455*
	$726*	$825*	$1039*	$1455*
	$721*	$820*	$1034*	$1450*
See Offers	$726*	$826*	$1040*	$1455*
See Offers	$727*	$826*	$1040*	$1456*
See Offers	$836*	$936*	$1129*	$1565*
See Offers	$836*	$936*	$1129*	$1565*
See Offers	$836*	$936*	$1129*	$1565*
See Offers	$837*	$937*	$1129*	$1566*
	$836*	$936*	$1129*	$1565*
	$831*	$931*	$1124*	$1560*
See Offers	$837*	$937*	$1129*	$1566*
See Offers	$837*	$937*	$1129*	$1566*
See Offers	$998*	$1099*	$1291*	$1727*
See Offers	$998*	$1099*	$1291*	$1727*
See Offers	$998*	$1099*	$1291*	$1727*
See Offers	$999*	$1099*	$1292*	$1728*
	$998*	$1099*	$1291*	$1727*
	$993*	$1094*	$1286*	$1722*
See Offers	$999*	$1099*	$1292*	$1728*
See Offers	$999*	$1100*	$1292*	$1728*

Ports

Cartagena, Colombia
Oranjestad, Aruba
Willemstad, Curacao
Colon, Panama

View more ports

Ports

Cartagena, Colombia - Oranjestad, Aruba - Willemstad, Curacao - Colon, Panama - View more ports

7 Night Southern Caribbean (Cartagena Roundtrip)

Serenade of the Seas L

4.1

(1797 Reviews)

2026 sail dates: Jan 11, Mar 08

$930*

$133/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1797 Serenade of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$949*	$999*	$1122*	$1551*
See Offers	$949*	$999*	$1122*	$1551*
See Offers	$949*	$999*	$1122*	$1551*
See Offers	$950*	$999*	$1122*	$1551*
	$949*	$999*	$1122*	$1551*
	$944*	$994*	$1117*	$1546*
See Offers	$950*	$999*	$1122*	$1551*
See Offers	$950*	$999*	$1122*	$1551*
See Offers	$930*	$1030*	$1223*	$1652*
See Offers	$930*	$1030*	$1223*	$1652*
See Offers	$930*	$1030*	$1223*	$1652*
See Offers	$930*	$1031*	$1223*	$1652*
	$930*	$1030*	$1223*	$1652*
	$925*	$1025*	$1218*	$1647*
See Offers	$930*	$1031*	$1223*	$1652*
See Offers	$930*	$1031*	$1223*	$1652*

Ports

Colon, Panama
Cartagena, Colombia
Willemstad, Curacao
Oranjestad, Aruba

View more ports

Ports

Colon, Panama - Cartagena, Colombia - Willemstad, Curacao - Oranjestad, Aruba - View more ports

7 Night Southern Caribbean (Colon Roundtrip)

Serenade of the Seas L

4.1

(1797 Reviews)

2025 sail dates: Oct 11, Oct 25

2026 sail dates: Mar 14, Apr 11,

$836*

$119/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 1797 Serenade of the Seas reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$901*	$930*	$1004*	$1213*
See Offers	$901*	$930*	$1004*	$1213*
See Offers	$901*	$930*	$1004*	$1213*
See Offers	$901*	$931*	$1005*	$1214*
	$901*	$930*	$1004*	$1213*
	$896*	$925*	$999*	$1208*
See Offers	$901*	$931*	$1005*	$1214*
See Offers	$901*	$931*	$1005*	$1214*
See Offers	$851*	$908*	$974*	$1264*
See Offers	$851*	$908*	$974*	$1264*
See Offers	$851*	$908*	$974*	$1264*
See Offers	$852*	$908*	$974*	$1264*
	$851*	$908*	$974*	$1264*
	$846*	$903*	$969*	$1259*
See Offers	$852*	$908*	$974*	$1264*
See Offers	$852*	$908*	$974*	$1264*
See Offers	$836*	$936*	$1129*	$1565*
See Offers	$836*	$936*	$1129*	$1565*
See Offers	$836*	$936*	$1129*	$1565*
See Offers	$837*	$937*	$1129*	$1566*
	$836*	$936*	$1129*	$1565*
	$831*	$931*	$1124*	$1560*
See Offers	$837*	$937*	$1129*	$1566*
See Offers	$837*	$937*	$1129*	$1566*
See Offers	$928*	$1029*	$1221*	$1657*
See Offers	$928*	$1029*	$1221*	$1657*
See Offers	$928*	$1029*	$1221*	$1657*
See Offers	$929*	$1029*	$1222*	$1658*
	$928*	$1029*	$1221*	$1657*
	$923*	$1024*	$1216*	$1652*
See Offers	$929*	$1029*	$1222*	$1658*
See Offers	$929*	$1030*	$1222*	$1658*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Willemstad, Curacao
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman
Kralendijk, Bonaire
Oranjestad, Aruba

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Willemstad, Curacao - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - Kralendijk, Bonaire - Oranjestad, Aruba - View more ports

21 Night Panama Canal & Southern Caribbean: Abc Islands (Ft. Lauderdale Roundtrip)

Rotterdam L

4.4

(256 Reviews)

2025 sail dates: Oct 26

2026 sail dates: Feb 08, Mar 01

$2214*

$105/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 256 Rotterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2214*	$2934*	$3234*	$4894*
See Offers	$1854*	$2574*	$2874*	$4534*
	$1854*	$2574*	$2874*	$4534*
	$2459*	$3179*	$3474*	$5134*
See Offers	$2459*	$3179*	$3479*	$5139*
See Offers	$2459*	$3179*	$3479*	$5139*
See Offers	$1854*	$2574*	$2874*	$4534*
	$2634*	$3364*	$3654*	$5524*
See Offers	$2879*	$3609*	$3899*	$5769*
	$2879*	$3609*	$3899*	$5769*
	$2879*	$3609*	$3894*	$5764*
See Offers	$2879*	$3609*	$3899*	$5769*
See Offers	$2879*	$3609*	$3899*	$5769*
See Offers	$2879*	$3609*	$3899*	$5769*
	$2539*	$3259*	$3559*	$5429*
See Offers	$2784*	$3504*	$3804*	$5674*
	$2784*	$3504*	$3804*	$5674*
	$2784*	$3504*	$3799*	$5669*
See Offers	$2784*	$3504*	$3804*	$5674*
See Offers	$2784*	$3504*	$3804*	$5674*
See Offers	$2784*	$3504*	$3804*	$5674*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Oranjestad, Aruba
Cartagena, Colombia
Panama Canal (Cruise Into Canal)
Colon, Panama
Puerto Limon, Costa Rica
Ocho Rios, Jamaica

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Puerto Limon, Costa Rica - Ocho Rios, Jamaica - View more ports

12 Night Panama Canal Sunfarer (Ft. Lauderdale Roundtrip)

Rotterdam L

4.4

(256 Reviews)

2025 sail dates: Mar 16

$1064*

$89/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 256 Rotterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1064*	$1764*	$2564*	$3564*
See Offers	$1199*	$1899*	$2699*	$3699*
	$1199*	$1899*	$2699*	$3699*
	$1199*	$1899*	$2694*	$3694*
See Offers	$1199*	$1899*	$2699*	$3699*
See Offers	$1199*	$1899*	$2699*	$3699*
See Offers	$1199*	$1899*	$2699*	$3699*

Ports

Tampa, Florida
Puerto Limon, Costa Rica
Colon, Panama
George Town, Grand Cayman

View more ports

Ports

Tampa, Florida - Puerto Limon, Costa Rica - Colon, Panama - George Town, Grand Cayman - View more ports

8 Night Panama Canal - Partial Transit (Tampa Roundtrip)

Carnival Miracle L

4.0

(2755 Reviews)

2026 sail dates: Jan 17, Mar 14

$1024*

$128/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 2755 Carnival Miracle reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
See Offers	$1024*	$1174*	$1434*	N/A
See Offers	$1024*	$1174*	$1434*	N/A
	$1024*	$1174*	$1434*	N/A
	$1014*	$1164*	$1424*	N/A
See Offers	$1024*	$1174*	$1434*	N/A
See Offers	$1054*	$1204*	$1404*	$2704*
See Offers	$1054*	$1204*	$1404*	$2704*
	$1054*	$1204*	$1404*	$2704*
	$1044*	$1194*	$1394*	$2694*
See Offers	$1054*	$1204*	$1404*	$2704*

Ports

Ft. Lauderdale (Port Everglades), Florida
Half Moon Cay, Bahamas (Private Island)
Willemstad, Curacao
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

12 Night Panama Canal Discovery: Costa Rica & Greater Antilles (Ft. Lauderdale Roundtrip)

Rotterdam L

4.4

(256 Reviews)

2025 sail dates: Oct 26, Dec 07

2026 sail dates: Feb 08, Mar 01

$1374*

$115/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 256 Rotterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$1469*	$2019*	$2169*	$3519*
See Offers	$1614*	$2164*	$2314*	$3664*
	$1614*	$2164*	$2314*	$3664*
	$1614*	$2164*	$2309*	$3659*
See Offers	$1614*	$2164*	$2314*	$3664*
See Offers	$1614*	$2164*	$2314*	$3664*
See Offers	$1614*	$2164*	$2314*	$3664*
	$1374*	$1924*	$2074*	$3424*
See Offers	$1519*	$2069*	$2219*	$3569*
	$1519*	$2069*	$2219*	$3569*
	$1519*	$2069*	$2214*	$3564*
See Offers	$1519*	$2069*	$2219*	$3569*
See Offers	$1519*	$2069*	$2219*	$3569*
See Offers	$1519*	$2069*	$2219*	$3569*
	$1764*	$2314*	$2464*	$3864*
See Offers	$1909*	$2459*	$2609*	$4009*
	$1909*	$2459*	$2609*	$4009*
	$1909*	$2459*	$2604*	$4004*
See Offers	$1909*	$2459*	$2609*	$4009*
See Offers	$1909*	$2459*	$2609*	$4009*
See Offers	$1909*	$2459*	$2609*	$4009*
	$1654*	$2204*	$2354*	$3964*
See Offers	$1799*	$2349*	$2499*	$3959*
	$1799*	$2349*	$2499*	$3959*
	$1799*	$2349*	$2494*	$4104*
See Offers	$1799*	$2349*	$2499*	$4109*
See Offers	$1799*	$2349*	$2499*	$4109*
See Offers	$1799*	$2349*	$2499*	$3959*

Ports

Ft. Lauderdale (Port Everglades), Florida
Willemstad, Curacao
Kralendijk, Bonaire
Oranjestad, Aruba
Half Moon Cay, Bahamas (Private Island)
Cartagena, Colombia
Colon, Panama
Panama Canal (Cruise Into Canal)
Puerto Limon, Costa Rica
George Town, Grand Cayman

View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Willemstad, Curacao - Kralendijk, Bonaire - Oranjestad, Aruba - Half Moon Cay, Bahamas (Private Island) - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - George Town, Grand Cayman - View more ports

21 Night Southern Caribbean & Panama Canal: Abc Islands (Ft. Lauderdale Roundtrip)

Rotterdam L

4.4

(256 Reviews)

2026 sail dates: Jan 30, Feb 20

$2544*

$121/night*

Inside

View Deal

Compare

Loading itinerary...

Loading reviews...

Read all 256 Rotterdam reviews

Compare Prices

Bonus Offers	Inside	Oceanview	Balcony	Suite
	$2554*	$3274*	$3614*	$5444*
See Offers	$2799*	$3519*	$3859*	$5689*
	$2799*	$3519*	$3859*	$5689*
	$2799*	$3519*	$3854*	$5684*
See Offers	$2799*	$3519*	$3859*	$5689*
See Offers	$2799*	$3519*	$3859*	$5689*
See Offers	$2799*	$3519*	$3859*	$5689*
	$2544*	$3264*	$3564*	$5434*
See Offers	$2789*	$3509*	$3809*	$5679*
	$2789*	$3509*	$3809*	$5679*
	$2789*	$3509*	$3804*	$5674*
See Offers	$2789*	$3509*	$3809*	$5679*
See Offers	$2789*	$3509*	$3809*	$5679*
See Offers	$2789*	$3509*	$3809*	$5679*

221 - 228 of 228

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

Colon, Panama cruises 228 Colon, Panama cruises

Your search Clear selections

228 cruises found

Sort by

Filter by