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Panama Canal, Central America cruises 325 Panama Canal, Central America Cruises Found

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325 cruises found

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Ports

  • Seattle, Washington
  • Ketchikan, Alaska
  • Cruise Tracy Arm Fjord, Alaska
  • Juneau, Alaska
  • Sitka, Alaska
  • Victoria, British Columbia
  • San Francisco, California
  • Los Angeles, California
  • Cabo San Lucas, Mexico
  • Puntarenas, Costa Rica
  • Panama Canal Transit
  • Cartagena, Colombia
  • Oranjestad, Aruba
  • Miami, Florida
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Ports

Seattle, Washington - Ketchikan, Alaska - Cruise Tracy Arm Fjord, Alaska - Juneau, Alaska - Sitka, Alaska - Victoria, British Columbia - San Francisco, California - Los Angeles, California - Cabo San Lucas, Mexico - Puntarenas, Costa Rica - Panama Canal Transit - Cartagena, Colombia - Oranjestad, Aruba - Miami, Florida - View more ports

Queen Elizabeth M

3.9
(126 Reviews)

2025 sail dates:

$4921*
$176/night*
Inside
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$4921* cunard.com $4399* luxuryonly.com $4399* cruisesonly.com $4399* cruises.com $4299* gotosea.com $4399* dreamvacations.com $4199* americandiscountcruises.com $4199* americandiscountvacations.com
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Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • George Town, Grand Cayman
  • Costa Maya (Mahahual), Mexico
  • Belize City, Belize
  • Coxen Hole, Roatan, Bay Islands, Honduras
  • Cartagena, Colombia
  • Panama Canal Transit
  • Fuerte Amador, Panama
  • Manta, Ecuador
  • Guayaquil, Equador
  • Salaverry (Trujillo), Peru
  • Callao (Lima), Peru
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Costa Maya (Mahahual), Mexico - Belize City, Belize - Coxen Hole, Roatan, Bay Islands, Honduras - Cartagena, Colombia - Panama Canal Transit - Fuerte Amador, Panama - Manta, Ecuador - Guayaquil, Equador - Salaverry (Trujillo), Peru - Callao (Lima), Peru - View more ports

Crystal Serenity XL

4.4
(103 Reviews)

2025 sail dates:

$9100*
$506/night*
Oceanview
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$9100* gotosea.com $9100* americandiscountcruises.com $9100* americandiscountvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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$9100*

$9600*

$10300*

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Ports

  • Miami, Florida
  • George Town, Grand Cayman
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Corinto, Nicaragua
  • Puerto Quetzal, Guatemala
  • Acapulco, Mexico
  • Cabo San Lucas, Mexico
  • Ensenada, Mexico
  • San Pedro (Los Angeles), California
  • Puerto Plata, Dominican Republic
  • San Juan, Puerto Rico
  • Basseterre, St. Kitts
  • Pointe-A-Pitre, Guadeloupe
  • Castries, St. Lucia
  • St. John's, Antigua
  • St. George's, Grenada
  • Bridgetown, Barbados
  • Roseau, Dominica
  • Gustavia, St. Barthelemy
  • Costa Maya (Mahahual), Mexico
  • Harvest Caye, Belize
  • Coxen Hole, Roatan, Bay Islands, Honduras
  • Cozumel, Mexico
  • Oranjestad, Aruba
  • Willemstad, Curacao
  • Kralendijk, Bonaire
  • Great Stirrup Cay (Cruise Line Private Island), Bahamas
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Ports

Miami, Florida - George Town, Grand Cayman - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Corinto, Nicaragua - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - Ensenada, Mexico - San Pedro (Los Angeles), California - Puerto Plata, Dominican Republic - San Juan, Puerto Rico - Basseterre, St. Kitts - Pointe-A-Pitre, Guadeloupe - Castries, St. Lucia - St. John's, Antigua - St. George's, Grenada - Bridgetown, Barbados - Roseau, Dominica - Gustavia, St. Barthelemy - Costa Maya (Mahahual), Mexico - Harvest Caye, Belize - Coxen Hole, Roatan, Bay Islands, Honduras - Cozumel, Mexico - Oranjestad, Aruba - Willemstad, Curacao - Kralendijk, Bonaire - Great Stirrup Cay (Cruise Line Private Island), Bahamas - View more ports

Vista M

4.3
(36 Reviews)

2025 sail dates:

$36899*
$410/night*
Balcony
View Deal
$36899* luxuryonly.com $36899* cruisesonly.com $36899* cruises.com $36899* gotosea.com $36899* dreamvacations.com $36899* americandiscountcruises.com $36899* americandiscountvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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Ports

  • San Pedro (Los Angeles), California
  • Ensenada, Mexico
  • Cabo San Lucas, Mexico
  • Acapulco, Mexico
  • Puerto Quetzal, Guatemala
  • Puerto Corinto, Nicaragua
  • Panama City, Panama
  • Panama Canal Transit
  • Cartagena, Colombia
  • George Town, Grand Cayman
  • Miami, Florida
View more ports

Ports

San Pedro (Los Angeles), California - Ensenada, Mexico - Cabo San Lucas, Mexico - Acapulco, Mexico - Puerto Quetzal, Guatemala - Puerto Corinto, Nicaragua - Panama City, Panama - Panama Canal Transit - Cartagena, Colombia - George Town, Grand Cayman - Miami, Florida - View more ports

Seven Seas Grandeur M

4.0
(6 Reviews)

2025 sail dates:

$11499*
$719/night*
Suite
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$11499* luxuryonly.com $11499* cruisesonly.com $11499* cruises.com $11499* dreamvacations.com
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$11499*

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Ports

  • Miami, Florida
  • George Town, Grand Cayman
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Corinto, Nicaragua
  • Puerto Quetzal, Guatemala
  • Acapulco, Mexico
  • Cabo San Lucas, Mexico
  • Ensenada, Mexico
  • San Pedro (Los Angeles), California
View more ports

Ports

Miami, Florida - George Town, Grand Cayman - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Corinto, Nicaragua - Puerto Quetzal, Guatemala - Acapulco, Mexico - Cabo San Lucas, Mexico - Ensenada, Mexico - San Pedro (Los Angeles), California - View more ports

Vista M

4.3
(36 Reviews)

2025 sail dates:

$6999*
$437/night*
Balcony
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$6999* luxuryonly.com $6999* cruisesonly.com $6999* cruises.com $6999* gotosea.com $6999* dreamvacations.com $6999* americandiscountcruises.com $6999* americandiscountvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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$6999*

$17499*

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Ports

  • Southampton (London), England
  • New York, New York
  • Oranjestad, Aruba
  • Panama Canal Transit
  • Puerto Quetzal, Guatemala
  • Cabo San Lucas, Mexico
  • San Francisco, California
View more ports

Ports

Southampton (London), England - New York, New York - Oranjestad, Aruba - Panama Canal Transit - Puerto Quetzal, Guatemala - Cabo San Lucas, Mexico - San Francisco, California - View more ports

Queen Anne L

4.7
(1 Reviews)

2025 sail dates:

$3605*
$139/night*
Inside
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$3605* cunard.com $3809* luxuryonly.com $3809* cruisesonly.com $3809* cruises.com $3809* gotosea.com $3809* dreamvacations.com $3809* americandiscountcruises.com $3809* americandiscountvacations.com
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Ports

  • PANAMA CITY (FUERTE AMADOR), PANAMA
  • Panama Canal Transit
  • Cartagena, Colombia
  • Oranjestad, Aruba
  • Ft. Lauderdale (Port Everglades), Florida
View more ports

Ports

PANAMA CITY (FUERTE AMADOR), PANAMA - Panama Canal Transit - Cartagena, Colombia - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - View more ports

Silver Ray M

2025 sail dates:

$5100*
$567/night*
Suite
View Deal
$5100* luxuryonly.com $5100* cruisesonly.com $5100* cruises.com $5100* gotosea.com $5100* dreamvacations.com $5100* americandiscountcruises.com $5100* americandiscountvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Cartagena, Colombia
  • Panama Canal (Cruise Into Canal)
  • Colon, Panama
  • Oranjestad, Aruba
  • Willemstad, Curacao
  • Kralendijk, Bonaire
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal (Cruise Into Canal) - Colon, Panama - Oranjestad, Aruba - Willemstad, Curacao - Kralendijk, Bonaire - View more ports

Celebrity Beyond L

4.5
(192 Reviews)

2025 sail dates: Jan 13, Apr 07

$1110*
$101/night*
Inside
View Deal
$1110* cruisesonly.com $1110* cruises.com $1111* gotosea.com $1110* dreamvacations.com $1099* americandiscountcruises.com $1099* americandiscountvacations.com $1111* directlinecruises.com $1110* cheapcruises.com
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Ports

  • New York, New York
  • Oranjestad, Aruba
  • Panama Canal Transit
  • Puerto Quetzal, Guatemala
  • Cabo San Lucas, Mexico
  • San Francisco, California
View more ports

Ports

New York, New York - Oranjestad, Aruba - Panama Canal Transit - Puerto Quetzal, Guatemala - Cabo San Lucas, Mexico - San Francisco, California - View more ports

Queen Anne L

4.7
(1 Reviews)

2025 sail dates:

$2183*
$128/night*
Inside
View Deal
$2183* cunard.com $2649* luxuryonly.com $2649* cruisesonly.com $2649* cruises.com $2649* gotosea.com $2649* dreamvacations.com $2649* americandiscountcruises.com $2649* americandiscountvacations.com
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Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Cozumel, Mexico
  • Panama Canal Transit
  • Manta, Ecuador
  • Salaverry (Trujillo), Peru
  • Callao (Lima), Peru
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cozumel, Mexico - Panama Canal Transit - Manta, Ecuador - Salaverry (Trujillo), Peru - Callao (Lima), Peru - View more ports

Silver Ray M

2025 sail dates:

$7800*
$650/night*
Suite
View Deal
$7800* luxuryonly.com $7800* cruisesonly.com $7800* cruises.com $7800* gotosea.com $7800* dreamvacations.com $7800* americandiscountcruises.com $7800* americandiscountvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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$7800*

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71 - 80 of 325

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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