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Cruises on American Cruise Line 160 cruises on American Cruise Line found

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Ports

  • Jacksonville, Florida
  • GREEN COVE SPRINGS, FL
  • PALATKA, FLORIDA
  • Amelia Island, Florida
  • ST. AUGUSTINE, FLORIDA
View more ports

Ports

Jacksonville, Florida - GREEN COVE SPRINGS, FL - PALATKA, FLORIDA - Amelia Island, Florida - ST. AUGUSTINE, FLORIDA - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates: Feb 03, Feb 24, Mar 03, Nov 21, Nov 28 More

2026 sail dates:

$5270*
$753/night*
Oceanview
View Deal
$5270* dreamvacations.com $5270* luxuryonly.com
Loading itinerary...
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$5270*

$6155*

$8195*

See Offers

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$5270*

$6155*

$8195*

 

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$5630*

$6575*

$8755*

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$6575*

$8755*

 

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$5630*

$6575*

$8755*

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$5630*

$6575*

$8755*

Ports

  • Jacksonville, Florida
  • GREEN COVE SPRINGS, FL
  • PALATKA, FLORIDA
  • Amelia Island, Florida
  • ST. AUGUSTINE, FLORIDA
View more ports

Ports

Jacksonville, Florida - GREEN COVE SPRINGS, FL - PALATKA, FLORIDA - Amelia Island, Florida - ST. AUGUSTINE, FLORIDA - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates: Feb 10

2026 sail dates: Jan 29, Feb 12, Feb 19, Feb 26, Mar 05, Mar 12, More

$5270*
$753/night*
Oceanview
View Deal
$5270* dreamvacations.com $5270* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$5270*

$6155*

$8195*

See Offers

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$5270*

$6155*

$8195*

 

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$5270*

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$5270*

$6155*

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Ports

  • Memphis, Tennessee
  • RIVER CRUISING
  • Vicksburg, Mississippi
  • Natchez, Mississippi
  • St. Francisville, Louisiana
  • Baton Rouge, Louisiana
  • Houmas House Plantation, Louisiana
  • New Orleans, Louisiana
View more ports

Ports

Memphis, Tennessee - RIVER CRUISING - Vicksburg, Mississippi - Natchez, Mississippi - St. Francisville, Louisiana - Baton Rouge, Louisiana - Houmas House Plantation, Louisiana - New Orleans, Louisiana - View more ports

American Serenade S

2025 sail dates: Mar 01, Mar 15, Mar 29, Apr 12, Apr 26, May 10, May 24, Jun 07, Sep 06, Sep 20, More

2026 sail dates: Feb 14, Mar 14, Mar 28, Apr 11, Apr 25, May 09, May 23, Jun 06, Sep 05, Sep 19, More

$5275*
$754/night*
Balcony
View Deal
$5275* dreamvacations.com $5275* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5635*

$7795*

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Ports

  • Memphis, Tennessee
  • RIVER CRUISING
  • Vicksburg, Mississippi
  • Natchez, Mississippi
  • St. Francisville, Louisiana
  • Baton Rouge, Louisiana
  • Houmas House Plantation, Louisiana
  • New Orleans, Louisiana
View more ports

Ports

Memphis, Tennessee - RIVER CRUISING - Vicksburg, Mississippi - Natchez, Mississippi - St. Francisville, Louisiana - Baton Rouge, Louisiana - Houmas House Plantation, Louisiana - New Orleans, Louisiana - View more ports

American Splendor S

4.1
(4 Reviews)

2025 sail dates: Mar 05, Mar 19, Apr 02, Apr 16, Apr 30, May 14, May 28, Jul 09, Oct 29, Nov 12, More

2026 sail dates: Mar 04, Mar 18, Apr 01, Apr 15, Apr 29, May 13, May 27, Jul 08, Nov 11, More

$4295*
$614/night*
Oceanview
View Deal
$4295* dreamvacations.com $4295* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 4 American Splendor reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$4610*

$5275*

$7295*

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$4610*

$5275*

$7295*

 

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$6800*

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$7795*

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Ports

  • Baltimore, Maryland
  • Yorktown, Virginia
  • Williamsburg, Virginia
  • CAMBRIDGE, MARYLAND
  • ST. MICHAELS, MARYLAND
  • ANNAPOLIS, MARYLAND
View more ports

Ports

Baltimore, Maryland - Yorktown, Virginia - Williamsburg, Virginia - CAMBRIDGE, MARYLAND - ST. MICHAELS, MARYLAND - ANNAPOLIS, MARYLAND - View more ports

American Legend S

2025 sail dates:

2026 sail dates:

$6995*
$999/night*
Balcony
View Deal
$6995* dreamvacations.com $6995* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$6995*

$9315*

See Offers

N/A

N/A

$6995*

$9315*

Ports

  • Nashville, Tennessee
  • CLARKSVILLE, TENNESSEE
  • Dover, Tennessee
  • RIVER CRUISING
  • Paducah, Kentucky
  • Memphis, Tennessee
View more ports

Ports

Nashville, Tennessee - CLARKSVILLE, TENNESSEE - Dover, Tennessee - RIVER CRUISING - Paducah, Kentucky - Memphis, Tennessee - View more ports

American Symphony S

4.2
(4 Reviews)

2025 sail dates: Jun 25, Aug 20, Oct 29 More

$4915*
$702/night*
Balcony
View Deal
$4915* dreamvacations.com $4915* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 4 American Symphony reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$5275*

$7295*

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$5275*

$7295*

 

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$4915*

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Ports

  • PROVIDENCE, RHODE ISLAND
  • NEW BEDFORD, MASSACHUSETTS
  • NANTUCKET, MASSACHUSETTS
  • Martha's Vineyard, Massachusetts
  • BLOCK ISLAND, RHODE ISLAND
  • Newport, Rhode Island
  • BRISTOL, RI
View more ports

Ports

PROVIDENCE, RHODE ISLAND - NEW BEDFORD, MASSACHUSETTS - NANTUCKET, MASSACHUSETTS - Martha's Vineyard, Massachusetts - BLOCK ISLAND, RHODE ISLAND - Newport, Rhode Island - BRISTOL, RI - View more ports

American Liberty XL

5.0
(1 Reviews)

2025 sail dates: Jun 26, Jul 03, Jul 10, Jul 17, Jul 24, Jul 31, Aug 07, Aug 21, Aug 28, Sep 04, Sep 11, Sep 18, Sep 25 More

2026 sail dates: Jul 05, Jul 19, Jul 26, Aug 02, Aug 09, Aug 16, Aug 23, Aug 30, Sep 06, Sep 13, Sep 20 More

$7790*
$1113/night*
Balcony
View Deal
$7790* dreamvacations.com $7790* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$7835*

$10435*

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$10435*

 

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Ports

  • New York, New York
  • PORT JEFF, NEW YORK
  • OLD SAYBROOK, CONNECTICUT
  • New London, Connecticut
  • Newport, Rhode Island
  • Plymouth, Massachusetts
  • Boston, Massachusetts
View more ports

Ports

New York, New York - PORT JEFF, NEW YORK - OLD SAYBROOK, CONNECTICUT - New London, Connecticut - Newport, Rhode Island - Plymouth, Massachusetts - Boston, Massachusetts - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates: Jul 01, Sep 10

2026 sail dates:

$6350*
$907/night*
Oceanview
View Deal
$6350* dreamvacations.com $6350* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$6710*

$7835*

$10435*

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$6710*

$7835*

$10435*

 

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$7070*

$8255*

$10990*

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$7070*

$8255*

$10990*

 

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$6350*

$7415*

$9875*

See Offers

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$6350*

$7415*

$9875*

Ports

  • Pittsburgh, Pennsylvania
  • RIVER CRUISING
  • MARIETTA, OHIO
  • MAYSVILLE, KENTUCKY
  • Cincinnati, Ohio
  • Louisville, Kentucky
  • Henderson, Kentucky
  • EVANSVILLE, INDIANA
  • Paducah, Kentucky
  • Cape Girardeau, Missouri
  • St. Louis, Missouri
View more ports

Ports

Pittsburgh, Pennsylvania - RIVER CRUISING - MARIETTA, OHIO - MAYSVILLE, KENTUCKY - Cincinnati, Ohio - Louisville, Kentucky - Henderson, Kentucky - EVANSVILLE, INDIANA - Paducah, Kentucky - Cape Girardeau, Missouri - St. Louis, Missouri - View more ports

American Melody S

5.0
(8 Reviews)

2025 sail dates:

2026 sail dates:

$9015*
$644/night*
Balcony
View Deal
$9015* dreamvacations.com $9015* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 8 American Melody reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$9015*

$12365*

See Offers

N/A

N/A

$9015*

$12365*

Ports

  • St. Paul, Minnesota
  • Red Wing, Minnesota
  • Winona, Minnesota
  • Dubuque, Iowa
  • DAVENPORT, IOWA
  • FORT MADISON, IOWA
  • Hannibal, Missouri
  • St. Louis, Missouri
View more ports

Ports

St. Paul, Minnesota - Red Wing, Minnesota - Winona, Minnesota - Dubuque, Iowa - DAVENPORT, IOWA - FORT MADISON, IOWA - Hannibal, Missouri - St. Louis, Missouri - View more ports

American Serenade S

2025 sail dates: Jul 05, Aug 02

2026 sail dates: Jul 04, Jul 18, Aug 01

$5635*
$805/night*
Balcony
View Deal
$5635* dreamvacations.com $5635* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

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$5635*

$7795*

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$5635*

$7795*

 

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1 - 10 of 160

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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