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Cruises on American Cruise Line 160 cruises on American Cruise Line found

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160 cruises found

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Ports

  • Amelia Island, Florida
  • JEKYLL ISLAND, GEORGIA
  • Savannah, Georgia
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • BEAUFORT, SOUTH CAROLINA
  • Charleston, South Carolina
View more ports

Ports

Amelia Island, Florida - JEKYLL ISLAND, GEORGIA - Savannah, Georgia - HILTON HEAD ISLAND, SOUTH CAROLINA - BEAUFORT, SOUTH CAROLINA - Charleston, South Carolina - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates: Dec 27

2026 sail dates: Mar 19, Apr 02, Apr 16, Apr 30 More

$5270*
$753/night*
Oceanview
View Deal
$5270* dreamvacations.com $5270* luxuryonly.com
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$5270*

$6155*

$8195*

 

N/A

$5270*

$6155*

$8195*

 

N/A

$5270*

$6155*

$8195*

 

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$5270*

$6155*

$8195*

 

N/A

$5630*

$6575*

$8755*

 

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$5630*

$6575*

$8755*

 

N/A

$5990*

$6995*

$9315*

 

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$5990*

$6995*

$9315*

 

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$6995*

$9315*

 

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$6995*

$9315*

 

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$5990*

$6995*

$9315*

 

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$5990*

$6995*

$9315*

Ports

  • WASHINGTON, D.C. USA
  • ANNAPOLIS, MARYLAND
  • ST. MICHAELS, MARYLAND
  • CAMBRIDGE, MARYLAND
  • RIVER CRUISING
  • Norfolk, Virginia
  • Williamsburg, Virginia
  • Mt Vernon, Virginia
View more ports

Ports

WASHINGTON, D.C. USA - ANNAPOLIS, MARYLAND - ST. MICHAELS, MARYLAND - CAMBRIDGE, MARYLAND - RIVER CRUISING - Norfolk, Virginia - Williamsburg, Virginia - Mt Vernon, Virginia - View more ports

American Patriot S

2025 sail dates:

2026 sail dates: Oct 19, Oct 29,

$9020*
$902/night*
Balcony
View Deal
$9020* dreamvacations.com $9020* luxuryonly.com
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$9595*

$12775*

 

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$9595*

$12775*

 

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$9595*

$12775*

 

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$9595*

$12775*

 

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$9020*

$12010*

 

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N/A

$9020*

$12010*

Ports

  • Jacksonville, Florida
  • Amelia Island, Florida
  • RIVER CRUISING
  • ST. AUGUSTINE, FLORIDA
  • Port Canaveral, Florida
  • West Palm Beach, Florida
  • KEY BISCAYNE, FLORIDA
  • Key West, Florida
  • MARCO ISLAND, FLORIDA
  • PUNTA GORDA, FLORIDA
  • ST. PETERSBURG, FLORIDA
View more ports

Ports

Jacksonville, Florida - Amelia Island, Florida - RIVER CRUISING - ST. AUGUSTINE, FLORIDA - Port Canaveral, Florida - West Palm Beach, Florida - KEY BISCAYNE, FLORIDA - Key West, Florida - MARCO ISLAND, FLORIDA - PUNTA GORDA, FLORIDA - ST. PETERSBURG, FLORIDA - View more ports

American Pioneer S

2025 sail dates: Nov 01

2026 sail dates:

$12360*
$883/night*
Balcony
View Deal
$12360* dreamvacations.com $12360* luxuryonly.com
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$12380*

$14530*

 

N/A

N/A

$12380*

$14530*

 

N/A

N/A

$12360*

$14530*

 

N/A

N/A

$12360*

$14530*

Ports

  • Baltimore, Maryland
  • ST. MICHAELS, MARYLAND
  • Norfolk, Virginia
  • KITTY HAWK, NORTH CAROLINA
  • Morehead City, North Carolina
  • Wilmington, North Carolina
  • Charleston, South Carolina
  • BEAUFORT, SOUTH CAROLINA
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • Savannah, Georgia
  • ST. SIMONS ISLAND, GEORGIA
  • JEKYLL ISLAND, GEORGIA
  • FERNANDINA BEACH, FL
  • Amelia Island, Florida
  • Jacksonville, Florida
View more ports

Ports

Baltimore, Maryland - ST. MICHAELS, MARYLAND - Norfolk, Virginia - KITTY HAWK, NORTH CAROLINA - Morehead City, North Carolina - Wilmington, North Carolina - Charleston, South Carolina - BEAUFORT, SOUTH CAROLINA - HILTON HEAD ISLAND, SOUTH CAROLINA - Savannah, Georgia - ST. SIMONS ISLAND, GEORGIA - JEKYLL ISLAND, GEORGIA - FERNANDINA BEACH, FL - Amelia Island, Florida - Jacksonville, Florida - View more ports

American Liberty XL

5.0
(1 Reviews)

2025 sail dates:

2026 sail dates: Oct 27

$12360*
$883/night*
Balcony
View Deal
$12360* dreamvacations.com $12360* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$12360*

$16325*

 

N/A

N/A

$12360*

$16325*

 

N/A

N/A

$12360*

$16325*

 

N/A

N/A

$12360*

$16325*

Ports

  • Baltimore, Maryland
  • ST. MICHAELS, MARYLAND
  • Norfolk, Virginia
  • KITTY HAWK, NORTH CAROLINA
  • Morehead City, North Carolina
  • Wilmington, North Carolina
  • Charleston, South Carolina
  • BEAUFORT, SOUTH CAROLINA
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • Savannah, Georgia
  • ST. SIMONS ISLAND, GEORGIA
  • JEKYLL ISLAND, GEORGIA
  • FERNANDINA BEACH, FL
  • Jacksonville, Florida
View more ports

Ports

Baltimore, Maryland - ST. MICHAELS, MARYLAND - Norfolk, Virginia - KITTY HAWK, NORTH CAROLINA - Morehead City, North Carolina - Wilmington, North Carolina - Charleston, South Carolina - BEAUFORT, SOUTH CAROLINA - HILTON HEAD ISLAND, SOUTH CAROLINA - Savannah, Georgia - ST. SIMONS ISLAND, GEORGIA - JEKYLL ISLAND, GEORGIA - FERNANDINA BEACH, FL - Jacksonville, Florida - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates:

2026 sail dates:

$10585*
$756/night*
Oceanview
View Deal
$10585* dreamvacations.com $10585* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$10585*

$12360*

$16325*

 

N/A

$10585*

$12360*

$16325*

Ports

  • Jacksonville, Florida
  • Amelia Island, Florida
  • RIVER CRUISING
  • ST. AUGUSTINE, FLORIDA
  • Port Canaveral, Florida
  • West Palm Beach, Florida
  • KEY BISCAYNE, FLORIDA
  • Key West, Florida
  • MARCO ISLAND, FLORIDA
  • PUNTA GORDA, FLORIDA
  • ST. PETERSBURG, FLORIDA
View more ports

Ports

Jacksonville, Florida - Amelia Island, Florida - RIVER CRUISING - ST. AUGUSTINE, FLORIDA - Port Canaveral, Florida - West Palm Beach, Florida - KEY BISCAYNE, FLORIDA - Key West, Florida - MARCO ISLAND, FLORIDA - PUNTA GORDA, FLORIDA - ST. PETERSBURG, FLORIDA - View more ports

American Patriot S

2025 sail dates: Nov 10

2026 sail dates:

$12360*
$883/night*
Balcony
View Deal
$12360* dreamvacations.com $12360* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$12380*

$16325*

 

N/A

N/A

$12380*

$16325*

 

N/A

N/A

$12360*

$16325*

 

N/A

N/A

$12360*

$16325*

Ports

  • ST. PETERSBURG, FLORIDA
  • MARCO ISLAND, FLORIDA
  • Key West, Florida
  • PUNTA GORDA, FLORIDA
View more ports

Ports

ST. PETERSBURG, FLORIDA - MARCO ISLAND, FLORIDA - Key West, Florida - PUNTA GORDA, FLORIDA - View more ports

American Pioneer S

2025 sail dates: Nov 22, Nov 29, Dec 06, Dec 13, Dec 20, Dec 27 More

2026 sail dates: Jan 03, Jan 10, Jan 17, Jan 24, Jan 31, Mar 07, Mar 14, Mar 21, Nov 14, Nov 21, Nov 28, Dec 05, Dec 12, Dec 19, Dec 26, More

$6995*
$999/night*
Balcony
View Deal
$6995* dreamvacations.com $6995* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

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N/A

$6995*

$8290*

 

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$6995*

$8290*

 

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$8290*

 

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$8290*

 

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$8290*

 

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$8290*

 

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$7415*

$8785*

 

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$7415*

$8785*

 

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$7415*

$8785*

 

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$7415*

$8785*

 

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$7415*

$8785*

 

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$7415*

$8785*

 

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$6995*

$8290*

 

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$8290*

 

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$8290*

 

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$8290*

 

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$8290*

 

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$8290*

 

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$6995*

$8290*

Ports

  • ST. PETERSBURG, FLORIDA
  • MARCO ISLAND, FLORIDA
  • Key West, Florida
  • PUNTA GORDA, FLORIDA
View more ports

Ports

ST. PETERSBURG, FLORIDA - MARCO ISLAND, FLORIDA - Key West, Florida - PUNTA GORDA, FLORIDA - View more ports

American Patriot S

2025 sail dates: Nov 24, Dec 01, Dec 15, Dec 22, Dec 29 More

2026 sail dates: Jan 05, Jan 12, Jan 19, Jan 26, Feb 02, Feb 09, Feb 16, Feb 23, Mar 02, Mar 09, Mar 16, Mar 23, Mar 30, Dec 07, Dec 14, Dec 21, Dec 28 More

$6995*
$999/night*
Balcony
View Deal
$6995* dreamvacations.com $6995* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$6995*

$9315*

 

N/A

N/A

$6995*

$9315*

 

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$6995*

$9315*

 

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$6995*

$9315*

Ports

  • Seattle, Washington
  • ANACORTES, WASHINGTON
  • FRIDAY HARBOR, SAN JUAN ISLAND, WASHINGTON
  • Victoria, British Columbia
  • PORT TOWNSEND, WASHINGTON
  • POULSBO, WA
View more ports

Ports

Seattle, Washington - ANACORTES, WASHINGTON - FRIDAY HARBOR, SAN JUAN ISLAND, WASHINGTON - Victoria, British Columbia - PORT TOWNSEND, WASHINGTON - POULSBO, WA - View more ports

American Constellation S

4.9
(7 Reviews)

2026 sail dates: Apr 06, Apr 13, Apr 20, Apr 27, May 04, Sep 29, Oct 06, Oct 13, Oct 20, More

$4775*
$682/night*
Oceanview
View Deal
$4775* dreamvacations.com $4775* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Read all 7 American Constellation reviews

Ports

  • Amelia Island, Florida
  • JEKYLL ISLAND, GEORGIA
  • Savannah, Georgia
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • BEAUFORT, SOUTH CAROLINA
  • Charleston, South Carolina
View more ports

Ports

Amelia Island, Florida - JEKYLL ISLAND, GEORGIA - Savannah, Georgia - HILTON HEAD ISLAND, SOUTH CAROLINA - BEAUFORT, SOUTH CAROLINA - Charleston, South Carolina - View more ports

American Glory S

5.0
(1 Reviews)

2026 sail dates: Mar 21, Apr 04, Nov 18, Dec 16 More

$5630*
$804/night*
Oceanview
View Deal
$5630* dreamvacations.com $5630* luxuryonly.com
Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

$5630*

$6575*

$8755*

 

N/A

$5630*

$6575*

$8755*

 

N/A

$5990*

$6995*

$9315*

 

N/A

$5990*

$6995*

$9315*

 

N/A

$5630*

$6575*

$8755*

 

N/A

$5630*

$6575*

$8755*

 

N/A

$5630*

$6575*

$8755*

 

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$5630*

$6575*

$8755*

 

N/A

$5630*

$6575*

$8755*

 

N/A

$5630*

$6575*

$8755*

21 - 30 of 160

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

More cruise destinations for American Cruise Line

More departure ports with American Cruise Line