Cruises on American Cruise Line 160 cruises on American Cruise Line found

Your search Clear selections

Any Destination
All Sail Months
Any Length
Any Port
American Cruise Line
Any Ship

Close

160 cruises found

Sort by

Filter by

More

Ports

  • Amelia Island, Florida
  • JEKYLL ISLAND, GEORGIA
  • Savannah, Georgia
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • BEAUFORT, SOUTH CAROLINA
  • Charleston, South Carolina
View more ports

Ports

Amelia Island, Florida - JEKYLL ISLAND, GEORGIA - Savannah, Georgia - HILTON HEAD ISLAND, SOUTH CAROLINA - BEAUFORT, SOUTH CAROLINA - Charleston, South Carolina - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Ports

  • Charleston, South Carolina
  • BEAUFORT, SOUTH CAROLINA
  • HILTON HEAD ISLAND, SOUTH CAROLINA
  • Savannah, Georgia
  • JEKYLL ISLAND, GEORGIA
  • Amelia Island, Florida
  • Jacksonville, Florida
View more ports

Ports

Charleston, South Carolina - BEAUFORT, SOUTH CAROLINA - HILTON HEAD ISLAND, SOUTH CAROLINA - Savannah, Georgia - JEKYLL ISLAND, GEORGIA - Amelia Island, Florida - Jacksonville, Florida - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Ports

  • ST. PETERSBURG, FLORIDA
  • PUNTA GORDA, FLORIDA
  • MARCO ISLAND, FLORIDA
  • Key West, Florida
  • KEY BISCAYNE, FLORIDA
  • West Palm Beach, Florida
  • Port Canaveral, Florida
  • ST. AUGUSTINE, FLORIDA
  • Amelia Island, Florida
  • RIVER CRUISING
  • Jacksonville, Florida
View more ports

Ports

ST. PETERSBURG, FLORIDA - PUNTA GORDA, FLORIDA - MARCO ISLAND, FLORIDA - Key West, Florida - KEY BISCAYNE, FLORIDA - West Palm Beach, Florida - Port Canaveral, Florida - ST. AUGUSTINE, FLORIDA - Amelia Island, Florida - RIVER CRUISING - Jacksonville, Florida - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$11570*

$13600*

See Offers

N/A

N/A

$11570*

$13600*

Ports

  • New Orleans, Louisiana
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • RIVER CRUISING
  • Memphis, Tennessee
View more ports

Ports

New Orleans, Louisiana - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - RIVER CRUISING - Memphis, Tennessee - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$5995*

$8290*

See Offers

N/A

N/A

$5995*

$8290*

Ports

  • Portland, Oregon
  • HAYDEN ISLAND, PORTLAND, OREGON
  • Astoria, Oregon
  • Mount St. Helens, Washington
  • Cruise Columbia River
  • THE DALLES, OREGON
  • Pendleton, Oregon
  • CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA
  • Clarkston, Washington
View more ports

Ports

Portland, Oregon - HAYDEN ISLAND, PORTLAND, OREGON - Astoria, Oregon - Mount St. Helens, Washington - Cruise Columbia River - THE DALLES, OREGON - Pendleton, Oregon - CRUISE SNAKE RIVER, PACIFIC NORTHWEST, USA - Clarkston, Washington - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$5995*

$8290*

See Offers

N/A

N/A

$5995*

$8290*

 

N/A

N/A

$6355*

$8785*

See Offers

N/A

N/A

$6355*

$8785*

 

N/A

N/A

$6355*

$8785*

See Offers

N/A

N/A

$6355*

$8785*

 

N/A

N/A

$6355*

$8785*

See Offers

N/A

N/A

$6355*

$8785*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$7075*

$9780*

See Offers

N/A

N/A

$7075*

$9780*

 

N/A

N/A

$7075*

$9780*

See Offers

N/A

N/A

$7075*

$9780*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

 

N/A

N/A

$6715*

$9285*

See Offers

N/A

N/A

$6715*

$9285*

Ports

  • Clarkston, Washington
  • Pendleton, Oregon
  • Cruise Columbia River
  • THE DALLES, OREGON
  • KALAMA, WASHINGTON
  • Astoria, Oregon
  • RIVER CRUISING
  • Portland, Oregon
View more ports

Ports

Clarkston, Washington - Pendleton, Oregon - Cruise Columbia River - THE DALLES, OREGON - KALAMA, WASHINGTON - Astoria, Oregon - RIVER CRUISING - Portland, Oregon - View more ports

Ports

  • ST. PETERSBURG, FLORIDA
  • PUNTA GORDA, FLORIDA
  • MARCO ISLAND, FLORIDA
  • Key West, Florida
  • KEY BISCAYNE, FLORIDA
  • West Palm Beach, Florida
  • Port Canaveral, Florida
  • ST. AUGUSTINE, FLORIDA
  • Amelia Island, Florida
  • RIVER CRUISING
  • Jacksonville, Florida
View more ports

Ports

ST. PETERSBURG, FLORIDA - PUNTA GORDA, FLORIDA - MARCO ISLAND, FLORIDA - Key West, Florida - KEY BISCAYNE, FLORIDA - West Palm Beach, Florida - Port Canaveral, Florida - ST. AUGUSTINE, FLORIDA - Amelia Island, Florida - RIVER CRUISING - Jacksonville, Florida - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$12380*

$16325*

See Offers

N/A

N/A

$12380*

$16325*

Ports

  • Portland, Oregon
  • Astoria, Oregon
  • KALAMA, WASHINGTON
  • THE DALLES, OREGON
  • Cruise Columbia River
  • Pendleton, Oregon
  • Clarkston, Washington
View more ports

Ports

Portland, Oregon - Astoria, Oregon - KALAMA, WASHINGTON - THE DALLES, OREGON - Cruise Columbia River - Pendleton, Oregon - Clarkston, Washington - View more ports

Ports

  • Boston, Massachusetts
  • Plymouth, Massachusetts
  • Newport, Rhode Island
  • New London, Connecticut
  • OLD SAYBROOK, CONNECTICUT
  • New York, New York
View more ports

Ports

Boston, Massachusetts - Plymouth, Massachusetts - Newport, Rhode Island - New London, Connecticut - OLD SAYBROOK, CONNECTICUT - New York, New York - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$7835*

$9285*

See Offers

N/A

N/A

$7835*

$9285*

Ports

  • Baltimore, Maryland
  • Yorktown, Virginia
  • Williamsburg, Virginia
  • CAMBRIDGE, MARYLAND
  • ST. MICHAELS, MARYLAND
  • ANNAPOLIS, MARYLAND
View more ports

Ports

Baltimore, Maryland - Yorktown, Virginia - Williamsburg, Virginia - CAMBRIDGE, MARYLAND - ST. MICHAELS, MARYLAND - ANNAPOLIS, MARYLAND - View more ports

Loading itinerary...
Loading reviews...

Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
 

N/A

N/A

$6575*

$8755*

See Offers

N/A

N/A

$6575*

$8755*

 

N/A

N/A

$6995*

$9315*

See Offers

N/A

N/A

$6995*

$9315*

 

N/A

N/A

$6995*

$9315*

See Offers

N/A

N/A

$6995*

$9315*

All prices are per person based on double occupancy and do not include port/government fees and gratuities.