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American Cruise Line Cruises to River Cruises - United States 125 cruises on American Cruise Line found

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Ports

  • New Orleans, Louisiana
  • OAK ALLEY PLANTATION, VACHERIE, LOUISIANA
  • Houmas House Plantation, Louisiana
  • Baton Rouge, Louisiana
  • St. Francisville, Louisiana
  • Natchez, Mississippi
  • Vicksburg, Mississippi
  • Greenville, Mississippi
  • Memphis, Tennessee
  • New Madrid, Missouri
  • Cape Girardeau, Missouri
  • CHESTER, ILLINOIS
  • St. Louis, Missouri
  • RIVER CRUISING
  • Hannibal, Missouri
  • FORT MADISON, IOWA
  • DAVENPORT, IOWA
  • Dubuque, Iowa
  • Winona, Minnesota
  • Red Wing, Minnesota
  • St. Paul, Minnesota
View more ports

Ports

New Orleans, Louisiana - OAK ALLEY PLANTATION, VACHERIE, LOUISIANA - Houmas House Plantation, Louisiana - Baton Rouge, Louisiana - St. Francisville, Louisiana - Natchez, Mississippi - Vicksburg, Mississippi - Greenville, Mississippi - Memphis, Tennessee - New Madrid, Missouri - Cape Girardeau, Missouri - CHESTER, ILLINOIS - St. Louis, Missouri - RIVER CRUISING - Hannibal, Missouri - FORT MADISON, IOWA - DAVENPORT, IOWA - Dubuque, Iowa - Winona, Minnesota - Red Wing, Minnesota - St. Paul, Minnesota - View more ports

American Serenade S

2025 sail dates:

2026 sail dates: Jun 13

$14890*
$709/night*
Balcony
View Deal
$14890* luxuryonly.com $14890* dreamvacations.com
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$14890*

$20790*

 

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$14890*

$20790*

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$15890*

$21790*

 

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$15890*

$21790*

Ports

  • St. Paul, Minnesota
  • Red Wing, Minnesota
  • Winona, Minnesota
  • Dubuque, Iowa
  • DAVENPORT, IOWA
  • FORT MADISON, IOWA
  • Hannibal, Missouri
  • St. Louis, Missouri
View more ports

Ports

St. Paul, Minnesota - Red Wing, Minnesota - Winona, Minnesota - Dubuque, Iowa - DAVENPORT, IOWA - FORT MADISON, IOWA - Hannibal, Missouri - St. Louis, Missouri - View more ports

American Melody S

5.0
(8 Reviews)

2025 sail dates: Jun 14, Sep 06, Sep 20, Oct 04 More

$4775*
$682/night*
Balcony
View Deal
$4775* luxuryonly.com $4775* dreamvacations.com
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$5635*

$7795*

 

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$5635*

$7795*

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$4775*

$6795*

 

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Ports

  • Juneau, Alaska
  • Haines, Alaska
  • Cruise Inside Passage, Alaska
  • Cruise Glacier Bay
  • Sitka, Alaska
  • Wrangell, Alaska
  • PETERSBURG, ALASKA
  • Cruise Tracy Arm Fjord, Alaska
View more ports

Ports

Juneau, Alaska - Haines, Alaska - Cruise Inside Passage, Alaska - Cruise Glacier Bay - Sitka, Alaska - Wrangell, Alaska - PETERSBURG, ALASKA - Cruise Tracy Arm Fjord, Alaska - View more ports

American Constellation S

4.9
(7 Reviews)

2025 sail dates: Jun 16, Jun 26, Jul 06, Jul 30, More

2026 sail dates: Jun 15, Jun 25, Jul 05, Jul 29, Aug 08 More

$8525*
$853/night*
Oceanview
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$8525* luxuryonly.com $8525* dreamvacations.com
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Ports

  • Nashville, Tennessee
  • CLARKSVILLE, TENNESSEE
  • Dover, Tennessee
  • RIVER CRUISING
  • Paducah, Kentucky
  • Memphis, Tennessee
View more ports

Ports

Nashville, Tennessee - CLARKSVILLE, TENNESSEE - Dover, Tennessee - RIVER CRUISING - Paducah, Kentucky - Memphis, Tennessee - View more ports

American Splendor S

4.1
(4 Reviews)

2025 sail dates: Jun 18, Sep 10, Sep 24, Oct 08, Oct 22 More

$3795*
$542/night*
Oceanview
View Deal
$3795* luxuryonly.com $3795* dreamvacations.com
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Ports

  • St. Louis, Missouri
  • Cape Girardeau, Missouri
  • RIVER CRUISING
  • Paducah, Kentucky
  • EVANSVILLE, INDIANA
  • Henderson, Kentucky
  • Louisville, Kentucky
  • Cincinnati, Ohio
  • MAYSVILLE, KENTUCKY
  • MARIETTA, OHIO
  • Pittsburgh, Pennsylvania
View more ports

Ports

St. Louis, Missouri - Cape Girardeau, Missouri - RIVER CRUISING - Paducah, Kentucky - EVANSVILLE, INDIANA - Henderson, Kentucky - Louisville, Kentucky - Cincinnati, Ohio - MAYSVILLE, KENTUCKY - MARIETTA, OHIO - Pittsburgh, Pennsylvania - View more ports

American Melody S

5.0
(8 Reviews)

2025 sail dates:

2026 sail dates: Aug 01

$9015*
$644/night*
Balcony
View Deal
$9015* luxuryonly.com $9015* dreamvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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$9015*

$12365*

 

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$9015*

$12365*

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$9015*

$12365*

 

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$9015*

$12365*

Ports

  • Nashville, Tennessee
  • CLARKSVILLE, TENNESSEE
  • Dover, Tennessee
  • RIVER CRUISING
  • Paducah, Kentucky
  • Memphis, Tennessee
View more ports

Ports

Nashville, Tennessee - CLARKSVILLE, TENNESSEE - Dover, Tennessee - RIVER CRUISING - Paducah, Kentucky - Memphis, Tennessee - View more ports

American Symphony S

4.2
(4 Reviews)

2025 sail dates: Jun 25, Aug 20, Oct 29 More

$4415*
$631/night*
Balcony
View Deal
$4415* luxuryonly.com $4415* dreamvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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$4775*

$6795*

 

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$4775*

$6795*

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$4415*

$6300*

 

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$4415*

$6300*

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$4915*

$6800*

 

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$4915*

$6800*

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$5275*

$7295*

 

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$5275*

$7295*

Ports

  • PROVIDENCE, RHODE ISLAND
  • NEW BEDFORD, MASSACHUSETTS
  • NANTUCKET, MASSACHUSETTS
  • Martha's Vineyard, Massachusetts
  • BLOCK ISLAND, RHODE ISLAND
  • Newport, Rhode Island
  • BRISTOL, RI
View more ports

Ports

PROVIDENCE, RHODE ISLAND - NEW BEDFORD, MASSACHUSETTS - NANTUCKET, MASSACHUSETTS - Martha's Vineyard, Massachusetts - BLOCK ISLAND, RHODE ISLAND - Newport, Rhode Island - BRISTOL, RI - View more ports

American Liberty XL

5.0
(1 Reviews)

2025 sail dates: Jun 26, Jul 03, Jul 10, Jul 17, Jul 24, Jul 31, Aug 07, Aug 21, Aug 28, Sep 04, Sep 11, Sep 18, Sep 25 More

2026 sail dates: Jun 28, Jul 05, Jul 19, Jul 26, Aug 02, Aug 09, Aug 16, Aug 23, Aug 30, Sep 06, Sep 13, Sep 20 More

$7390*
$1056/night*
Balcony
View Deal
$7390* luxuryonly.com $7390* dreamvacations.com
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Partners Bonus Offers Inside Oceanview Balcony Suite
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$7835*

$10435*

 

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$7835*

$10435*

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$10435*

 

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$10435*

 

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$7790*

$10990*

 

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$10990*

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$7390*

$10590*

 

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$8675*

$11550*

 

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$8675*

$11550*

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$8675*

$11550*

 

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$11550*

 

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Ports

  • New York, New York
  • PORT JEFF, NEW YORK
  • OLD SAYBROOK, CONNECTICUT
  • New London, Connecticut
  • Newport, Rhode Island
  • Plymouth, Massachusetts
  • Boston, Massachusetts
View more ports

Ports

New York, New York - PORT JEFF, NEW YORK - OLD SAYBROOK, CONNECTICUT - New London, Connecticut - Newport, Rhode Island - Plymouth, Massachusetts - Boston, Massachusetts - View more ports

American Eagle S

5.0
(2 Reviews)

2025 sail dates: Sep 10

2026 sail dates: Jun 30

$6210*
$887/night*
Oceanview
View Deal
$6210* luxuryonly.com $6210* dreamvacations.com
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

$6210*

$7335*

$9935*

 

N/A

$6210*

$7335*

$9935*

See Offers

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$7070*

$8255*

$10990*

 

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$7070*

$8255*

$10990*

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$6350*

$7415*

$9875*

 

N/A

$6350*

$7415*

$9875*

Ports

  • Pittsburgh, Pennsylvania
  • RIVER CRUISING
  • MARIETTA, OHIO
  • MAYSVILLE, KENTUCKY
  • Cincinnati, Ohio
  • Louisville, Kentucky
  • Henderson, Kentucky
  • EVANSVILLE, INDIANA
  • Paducah, Kentucky
  • Cape Girardeau, Missouri
  • St. Louis, Missouri
View more ports

Ports

Pittsburgh, Pennsylvania - RIVER CRUISING - MARIETTA, OHIO - MAYSVILLE, KENTUCKY - Cincinnati, Ohio - Louisville, Kentucky - Henderson, Kentucky - EVANSVILLE, INDIANA - Paducah, Kentucky - Cape Girardeau, Missouri - St. Louis, Missouri - View more ports

American Melody S

5.0
(8 Reviews)

2025 sail dates:

2026 sail dates:

$8515*
$608/night*
Balcony
View Deal
$8515* luxuryonly.com $8515* dreamvacations.com
Loading itinerary...
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Top positive review

Top critical review

Read all 8 American Melody reviews
Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

N/A

N/A

$8515*

$11865*

 

N/A

N/A

$8515*

$11865*

Ports

  • St. Paul, Minnesota
  • Red Wing, Minnesota
  • Winona, Minnesota
  • Dubuque, Iowa
  • DAVENPORT, IOWA
  • FORT MADISON, IOWA
  • Hannibal, Missouri
  • St. Louis, Missouri
View more ports

Ports

St. Paul, Minnesota - Red Wing, Minnesota - Winona, Minnesota - Dubuque, Iowa - DAVENPORT, IOWA - FORT MADISON, IOWA - Hannibal, Missouri - St. Louis, Missouri - View more ports

American Serenade S

2025 sail dates: Jul 05, Jul 19,

2026 sail dates: Jul 04, Jul 18, Aug 01

$5135*
$734/night*
Balcony
View Deal
$5135* luxuryonly.com $5135* dreamvacations.com
Loading itinerary...
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Top positive review

Top critical review

Partners Bonus Offers Inside Oceanview Balcony Suite
See Offers

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$5135*

$7295*

 

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$5135*

$7295*

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$5135*

$7295*

 

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$5135*

$7295*

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$5135*

$7295*

 

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$5135*

$7295*

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$5635*

$7795*

 

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$7795*

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81 - 90 of 125

All prices are per person based on double occupancy and do not include port/government fees and gratuities.

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