Holland America Line Cruises to Panama Canal, Central America 64 cruises on Holland America Line found

Your search Clear selections

Any Destination
All Sail Months
Any Length
Any Port
Holland America Line
Any Ship

Close

64 cruises found

Sort by

Filter by

More

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Half Moon Cay, Bahamas (Private Island)
  • Grand Turk Island
  • Amber Cove (Puerto Plata), Dominican Republic
  • Nassau, Bahamas
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Acajutla
  • Puerto Quetzal, Guatemala
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • San Diego, California
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Amber Cove (Puerto Plata), Dominican Republic - Nassau, Bahamas - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Acajutla - Puerto Quetzal, Guatemala - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Grand Turk Island
  • Oranjestad, Aruba
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puerto Caldera, Costa Rica
  • Acajutla
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • San Diego, California
  • Victoria, British Columbia
  • Vancouver (Canada Place), British Columbia
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal Transit - Puerto Caldera, Costa Rica - Acajutla - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Victoria, British Columbia - Vancouver (Canada Place), British Columbia - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Half Moon Cay, Bahamas (Private Island)
  • Oranjestad, Aruba
  • Cartagena, Colombia
  • Colon, Panama
  • Panama Canal (Cruise Into Canal)
  • Puerto Limon, Costa Rica
  • Falmouth, Jamaica
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Oranjestad, Aruba - Cartagena, Colombia - Colon, Panama - Panama Canal (Cruise Into Canal) - Puerto Limon, Costa Rica - Falmouth, Jamaica - View more ports

Ports

  • San Diego, California
  • Puerto Vallarta, Mexico
  • Huatulco, Mexico
  • Puerto Chiapas (Tapachula), Mexico
  • Puerto Quetzal, Guatemala
  • Acajutla
  • Puntarenas, Costa Rica
  • Panama Canal Transit
  • Oranjestad, Aruba
  • Ft. Lauderdale (Port Everglades), Florida
  • Grand Turk Island
  • San Juan, Puerto Rico
  • Charlotte Amalie, St. Thomas
  • Half Moon Cay, Bahamas (Private Island)
View more ports

Ports

San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Acajutla - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - San Juan, Puerto Rico - Charlotte Amalie, St. Thomas - Half Moon Cay, Bahamas (Private Island) - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Half Moon Cay, Bahamas (Private Island)
  • Falmouth, Jamaica
  • Mahogany Bay, Roatan, Bay Islands, Honduras
  • Belize City, Belize
  • Cozumel, Mexico
  • Key West, Florida
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Quetzal, Guatemala
  • Huatulco, Mexico
  • Puerto Vallarta, Mexico
  • San Diego, California
  • San Francisco, California
  • Victoria, British Columbia
  • Vancouver (Canada Place), British Columbia
  • Seattle, Washington
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Half Moon Cay, Bahamas (Private Island) - Falmouth, Jamaica - Mahogany Bay, Roatan, Bay Islands, Honduras - Belize City, Belize - Cozumel, Mexico - Key West, Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - San Diego, California - San Francisco, California - Victoria, British Columbia - Vancouver (Canada Place), British Columbia - Seattle, Washington - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Quetzal, Guatemala
  • Huatulco, Mexico
  • Puerto Vallarta, Mexico
  • San Diego, California
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Quetzal, Guatemala - Huatulco, Mexico - Puerto Vallarta, Mexico - San Diego, California - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • George Town, Grand Cayman
  • Panama Canal Transit
  • Fuerte Amador, Panama
  • Cross The Equator
  • Manta, Ecuador
  • Salaverry (Trujillo), Peru
  • Callao (Lima), Peru
  • General San Martin (Pisco), Peru
  • Coquimbo (La Serena), Chile
  • San Antonio, Chile
  • Puerto Montt, Chile
  • Puerto Chacabuco, Chile
  • Cruise Chilean Fjords
  • Cruise Canal Sarmiento
  • Punta Arenas, Chile
  • Cruise Cockburn & Beagle Channels
  • Cruise Strait Of Magellan
  • Cruise Glacier Alley
  • Ushuaia, Tierra Del Fuego, Argentina
  • Cruise Cape Horn
  • Port Stanley, Falkland Islands
  • Montevideo, Uruguay
  • Buenos Aires, Argentina
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - George Town, Grand Cayman - Panama Canal Transit - Fuerte Amador, Panama - Cross The Equator - Manta, Ecuador - Salaverry (Trujillo), Peru - Callao (Lima), Peru - General San Martin (Pisco), Peru - Coquimbo (La Serena), Chile - San Antonio, Chile - Puerto Montt, Chile - Puerto Chacabuco, Chile - Cruise Chilean Fjords - Cruise Canal Sarmiento - Punta Arenas, Chile - Cruise Cockburn & Beagle Channels - Cruise Strait Of Magellan - Cruise Glacier Alley - Ushuaia, Tierra Del Fuego, Argentina - Cruise Cape Horn - Port Stanley, Falkland Islands - Montevideo, Uruguay - Buenos Aires, Argentina - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Amber Cove (Puerto Plata), Dominican Republic
  • San Juan, Puerto Rico
  • Charlotte Amalie, St. Thomas
  • Half Moon Cay, Bahamas (Private Island)
  • Grand Turk Island
  • Oranjestad, Aruba
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • San Diego, California
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Amber Cove (Puerto Plata), Dominican Republic - San Juan, Puerto Rico - Charlotte Amalie, St. Thomas - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - View more ports

Ports

  • Ft. Lauderdale (Port Everglades), Florida
  • Amber Cove (Puerto Plata), Dominican Republic
  • San Juan, Puerto Rico
  • Charlotte Amalie, St. Thomas
  • Half Moon Cay, Bahamas (Private Island)
  • Grand Turk Island
  • Oranjestad, Aruba
  • Cartagena, Colombia
  • Panama Canal Transit
  • Puntarenas, Costa Rica
  • Puerto Vallarta, Mexico
  • Cabo San Lucas, Mexico
  • San Diego, California
  • Catalina Island, California
  • Vancouver (Canada Place), British Columbia
View more ports

Ports

Ft. Lauderdale (Port Everglades), Florida - Amber Cove (Puerto Plata), Dominican Republic - San Juan, Puerto Rico - Charlotte Amalie, St. Thomas - Half Moon Cay, Bahamas (Private Island) - Grand Turk Island - Oranjestad, Aruba - Cartagena, Colombia - Panama Canal Transit - Puntarenas, Costa Rica - Puerto Vallarta, Mexico - Cabo San Lucas, Mexico - San Diego, California - Catalina Island, California - Vancouver (Canada Place), British Columbia - View more ports

Ports

  • Seattle, Washington
  • Vancouver (Canada Place), British Columbia
  • Santa Barbara, California
  • San Diego, California
  • Puerto Vallarta, Mexico
  • Huatulco, Mexico
  • Puerto Chiapas (Tapachula), Mexico
  • Puerto Quetzal, Guatemala
  • Acajutla
  • Puntarenas, Costa Rica
  • Panama Canal Transit
  • Oranjestad, Aruba
  • Ft. Lauderdale (Port Everglades), Florida
  • Grand Turk Island
  • San Juan, Puerto Rico
  • Charlotte Amalie, St. Thomas
  • Half Moon Cay, Bahamas (Private Island)
View more ports

Ports

Seattle, Washington - Vancouver (Canada Place), British Columbia - Santa Barbara, California - San Diego, California - Puerto Vallarta, Mexico - Huatulco, Mexico - Puerto Chiapas (Tapachula), Mexico - Puerto Quetzal, Guatemala - Acajutla - Puntarenas, Costa Rica - Panama Canal Transit - Oranjestad, Aruba - Ft. Lauderdale (Port Everglades), Florida - Grand Turk Island - San Juan, Puerto Rico - Charlotte Amalie, St. Thomas - Half Moon Cay, Bahamas (Private Island) - View more ports

All prices are per person based on double occupancy and do not include port/government fees and gratuities.